Medicine composition for treating insomnia and preparation method for medicine composition
A composition and drug technology, applied in the field of pharmaceutical composition for treating insomnia and its preparation, achieving the effects of low production cost, simple preparation process, and shortened sleep induction period
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Embodiment 1
[0016] Embodiment 1: the preparation of water chestnut leaf ether extract
[0017] Accurately weigh 0.5kg of dry water chestnut leaf medicinal material, chop it, put it into a 6L round bottom flask, add petroleum ether at a ratio of 1:8 (kg:L), soak for 30min, and place it in a constant temperature water bath at 75°C Reflux extraction for 3 times, the first reflux extraction for 1 hour, the second reflux extraction for 45 minutes, the third reflux extraction for 30 minutes, filter, and discard the filtrate after recovering petroleum ether. After the filter residue was volatilized to remove petroleum ether, put it into a 6L round bottom flask In the method, diethyl ether was added at a ratio of solid to liquid of 1:8 (kg:L), soaked for 30 minutes, and placed in a constant temperature water bath at 40°C for reflux extraction for 3 times, the first reflux extraction was for 1 hour, the second reflux extraction was for 45 minutes, and the third Reflux for 30 minutes, filter, and c...
Embodiment 2
[0018] Embodiment 2: the preparation of water chestnut leaf ether extract
[0019] Accurately weigh 1.0kg of dry water chestnut leaf medicinal material, chop it, put it into a 10L round bottom flask, add petroleum ether at a material-liquid ratio of 1:7 (kg:L), soak for 45min, and place it in a constant temperature water bath at 75°C Reflux extraction 3 times, the first reflux extraction for 1.5h, the second reflux extraction for 1h, the third reflux extraction for 30min, filter, and discard the filtrate after recovering petroleum ether. In the bottom flask, add diethyl ether according to the ratio of solid to liquid of 1:7 (kg:L), soak for 45 minutes, put it in a constant temperature water bath at 40°C for reflux extraction for 3 times, the first reflux extraction for 1.5h, and the second reflux extraction for 1h , the 3rd reflux extraction for 30min, filtered, combined 3 extracts, the filtrate recovered the solvent under reduced pressure on a rotary evaporator, and the conce...
Embodiment 3
[0024] Experimental research on the sedative and hypnotic effect of the horseshoe leaf extract of embodiment 3 on mice
[0025] 50 clean-grade Kunming mice, half male and half male, weighing (20±2) g. They were randomly divided into blank control group, positive control group, ether extract group, ethanol extract group and ethyl acetate extract group, with 10 animals in each group, half male and half male. The ether extract group was given 40.0 mg / kg of the water chestnut ether extract prepared in Example 1 of the present invention, the ethanol extract group was given 40.0 mg / kg of the horseshoe leaf ethanol extract prepared in the above comparative example 1, and the ethyl acetate extract group Give the horseshoe leaf ethyl acetate extract 40.0mg / kg that above-mentioned comparative example 2 prepares, and positive control group gives diazepam 2mg / kg, and blank control group gives equal-volume normal saline; Once a day, for 3 consecutive days, the volume of gavage is 15ml / kg....
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