The control method of piperaquine phosphate impurity

Abstract

The invention relates to the field of piperaquine phosphate impurity control, and specifically relates to a control method of piperaquine phosphate impurity. The control method of piperaquine phosphate impurity comprises the following steps: 1), adding a non-polar solvent into a piperaquine phosphate crude product, stirring and filtering; 2), adding a polar solvent, conducting reflux, stirring and filtering; 3), adding a water / polar mixed solvent, stirring and dissolving at 90-110 DEG, adding activated carbon for decoloring and filtering to obtain a filtrate, cooling, crystallizing, filtering, washing and drying. The steps 1) 2) and 3) are not in a particular order. The control method of piperaquine phosphate impurity provided by the invention has the advantages of simple process, and extensive equipment and reagent sources, thus indirectly reducing cost for drug impurity removal, and can be widely applied to preparation of piperaquine phosphate.

Description

technical field

[0001] The invention relates to the field of impurity control of piperaquine phosphate, in particular to a method for controlling the impurity of piperaquine phosphate. Background technique

[0002] As one of the most dangerous diseases, malaria is still widely prevalent in the world (especially in tropical areas), and it threatens human health, and the situation is severe. With the intensification of drug resistance and changes in the human living environment, the current malaria epidemic situation is more serious than 30 years ago, involving more than 100 countries, with a population of 3 billion, and 500 million cases of clinical diagnosis each year.

[0003] Piperaquine is a bisquinoline antimalarial drug, which was synthesized by Shanghai Institute of Pharmaceutical Industry in my country and RhonePoulenc in France in the 1960s. The initial research results showed that piperaquine was effective against falciparum malaria, including anti-chloroquine falc...

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