A kind of clopidogrel bisulfate aspirin tablet pharmaceutical composition and preparation method thereof

A technology of clopidogrel bisulfate aspirin tablets and clopidogrel bisulfate, which is applied in the field of clopidogrel bisulfate aspirin tablet pharmaceutical composition and its preparation, can solve the problems of large capsules and poor taking compliance, and improve fluidity , stable quality, beneficial to the effect of bioavailability
CN104434932BActive Publication Date: 2017-05-24CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
Publication Date
2017-05-24

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Abstract

The invention provides a pharmaceutical composition of clopidogrel hydrogen sulfate and an acetylsalicylic acid tablet and a preparation method thereof, belonging to the field of pharmaceutical preparation. According to the pharmaceutical composition of clopidogrel hydrogen sulfate and the acetylsalicylic acid tablet provided by the invention, F-Melt is added into the formula, so that the flowability of materials is improved and the materials are uniformly mixed; and meanwhile, clopidogrel hydrogen sulfate and the acetylsalicylic acid tablet are respectively pressed into double-layer tablets, so that the two components are prevented from interacting, thereby benefiting the safety of clinical medication and the stability in the storage process.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of clopidogrel bisulfate aspirin tablets and a preparation method thereof. Background technique

[0002] Clopidogrel hydrogen sulfate, the chemical name is 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5-yl)acetate methyl ester hydrogensulfate, The chemical structural formula is:

[0003]

[0004] Clopidogrel is a platelet aggregation inhibitor that selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPlllb / llla complex. Inhibits platelet aggregation. It can also block the platelet aggregation caused by other agonists through the release of ADP.

[0005] Both aspirin and clopidogrel bisulfate have the effect of inhibiting platelet aggregation, the combination of the two can significantly enhance the anti-platelet activity, and ca...

Claims

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