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A kind of clopidogrel bisulfate aspirin tablet pharmaceutical composition and preparation method thereof

A technology of clopidogrel bisulfate aspirin tablets and clopidogrel bisulfate, which is applied in the field of clopidogrel bisulfate aspirin tablet pharmaceutical composition and its preparation, can solve the problems of large capsules and poor taking compliance, and improve fluidity , stable quality, beneficial to the effect of bioavailability

Active Publication Date: 2017-05-24
CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prepared capsules are relatively large, and the patient's compliance with taking them is poor.

Method used

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  • A kind of clopidogrel bisulfate aspirin tablet pharmaceutical composition and preparation method thereof
  • A kind of clopidogrel bisulfate aspirin tablet pharmaceutical composition and preparation method thereof
  • A kind of clopidogrel bisulfate aspirin tablet pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Clopidogrel bisulfate aspirin tablet prescription (in 1000 tablets)

[0064]

[0065] Preparation:

[0066] (1) Preparation of clopidogrel hydrogen sulfate mixed granules: 97.875g of clopidogrel hydrogen sulfate, 60g of mannitol, 60g of microcrystalline cellulose and 2.5g of F-Melt were added to the hopper and mixed; dry granulation; Granules, the sieve mesh number is 24 orders; The clopidogrel hydrogen sulfate granules prepared are added in the mixer, and the F-Melt of 2.5g is added to mix, and the clopidogrel hydrogen sulfate total mixing granules are obtained;

[0067] (2) Prepare aspirin blend powder: add 75g aspirin, 55g microcrystalline cellulose and 1.0g stearic acid into the hopper and mix to prepare aspirin blend powder;

[0068] (3) The clopidogrel bisulfate blended granules and the aspirin blended powder were respectively added to the two hoppers of the double-layer tablet press, and tableted.

Embodiment 2

[0069] Embodiment 2: Clopidogrel bisulfate aspirin tablet prescription (in 1000 tablets)

[0070]

[0071] Preparation method: with embodiment 1.

Embodiment 3

[0072] Embodiment 3: Clopidogrel bisulfate aspirin tablet prescription (in 1000 tablets)

[0073]

[0074] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention provides a pharmaceutical composition of clopidogrel hydrogen sulfate and an acetylsalicylic acid tablet and a preparation method thereof, belonging to the field of pharmaceutical preparation. According to the pharmaceutical composition of clopidogrel hydrogen sulfate and the acetylsalicylic acid tablet provided by the invention, F-Melt is added into the formula, so that the flowability of materials is improved and the materials are uniformly mixed; and meanwhile, clopidogrel hydrogen sulfate and the acetylsalicylic acid tablet are respectively pressed into double-layer tablets, so that the two components are prevented from interacting, thereby benefiting the safety of clinical medication and the stability in the storage process.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of clopidogrel bisulfate aspirin tablets and a preparation method thereof. Background technique [0002] Clopidogrel hydrogen sulfate, the chemical name is 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5-yl)acetate methyl ester hydrogensulfate, The chemical structural formula is: [0003] [0004] Clopidogrel is a platelet aggregation inhibitor that selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPlllb / llla complex. Inhibits platelet aggregation. It can also block the platelet aggregation caused by other agonists through the release of ADP. [0005] Both aspirin and clopidogrel bisulfate have the effect of inhibiting platelet aggregation, the combination of the two can significantly enhance the anti-platelet activity, and ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/616A61K9/20A61K47/38A61P7/02A61P9/10A61P9/00A61K31/4365
CPCA61K9/0053A61K9/2054A61K31/4365A61K31/616A61K2300/00
Inventor 王颖
Owner CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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