Preparation method of a simple high-bonding strength polymer microfluidic chip
A microfluidic chip and polymer technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of insufficient effective bonding area, chip reduction, leakage, etc., to increase the effective bonding area , Improve air tightness, and simple processing technology
Active Publication Date: 2016-07-06
BIODA DIAGNOSTICS WUHAN
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Problems solved by technology
On the contrary, without sufficient effective bonding area, the chip resistance to pressure will be reduced and leakage may occur
Method used
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Experimental program
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Embodiment Construction
[0021] The present invention is described in further detail below:
[0022] A simple method for preparing a polymer microfluidic chip with high bonding strength, the preparation method is carried out according to the following steps.
[0023] A. Substrate selection and treatment:
[0024] The substrate is made of polymer material with a thickness of 5mm. Clean the selected substrate with a dust-free cloth to remove oil and impurities on the surface of the substrate. Use a laser engraving machine to carve the overall outline and through holes of the microfluidic chip on the surface of the substrate. Laser engraving machine The power is 25%, the speed is five steps per second, and the polymer is any one of PMMA or PC or PDMS.
[0025] B. Film engraving preparation:
[0026] Clean the substrate treated in step A with a dust-free cloth, cover the engraved surface of the substrate with a 0.02mm thick adhesive film, and use a high-temperature sponge to rub back and forth on the ...
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The invention discloses a method for preparing a simple high-bonding-strength polymer microflow chip. The method comprises the following steps: 1) cleaning a substrate, and sculpturing the overall appearance and through holes; 2) covering the microflow chip substrate with a layer of adhesive membrane, and sculpturing channels; 3) cleaning a cover plate, and sculpturing the overall appearance and through holes; 4) combining the sculptured cover plate and the sculptured microflow chip substrate in a hot-pressing manner so as to form a chip structure; 5) injecting a UV adhesive into the channels, and sucking out the redundant UV adhesive in a vacuum sucking manner, so as to cover the inner walls of the channels of the chip with a layer of thin UV adhesive; and 6) putting the chip under an ultraviolet lamp, and radiating to completely cure the UV adhesive, thereby obtaining a complete microflow chip. The method disclosed by the invention is simple, and the prepared microflow chip has the characteristics of high bonding strength and high effective bonding area, and can be widely applied to the field of biochemical analysis.
Description
technical field [0001] The invention relates to a technique for preparing a polymer microfluidic chip with simple and high bonding strength, in particular to a method for preparing a microfluidic chip through an adhesive film and UV glue. Background technique [0002] The microfluidic chip is the core of the microanalysis system. The invention and application of the microfluidic chip has provided great convenience to the scientific fields such as chemistry, food, environment, and medicine, and promoted the miniaturization, integration, automation and convenience of some analyzes . It greatly saves the consumption of some chemical reactions on expensive chemical reagents, and also greatly improves the analysis efficiency and reduces the cost. [0003] Thermoplastic polymers are usually used to make microfluidic chips due to their low cost, easy fabrication, and chemical resistance, such as PC, PDMS, and PMMA. At present, thermoplastic polymers have been widely used in the f...
Claims
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IPC IPC(8): B01L3/00
Inventor 刘侃项坚真艾钊方义张守坤
Owner BIODA DIAGNOSTICS WUHAN