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Preparation method of radix physochlainae granules for relieving asthma

A granule and antiasthmatic technology, applied in the field of preparation of Huashanshen Pingchuan granules, can solve the problems of large side effects, complicated pathogenesis and the like, and achieve the effects of fast onset, high transfer rate and convenient administration.

Inactive Publication Date: 2015-04-08
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of the disease is very complicated, and there are various inducing factors. Western medicine mainly treats it with antibiotics, hormone drugs, β2 receptor stimulants, etc., with relatively large side effects.

Method used

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  • Preparation method of radix physochlainae granules for relieving asthma

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Experimental program
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Effect test

Embodiment 1

[0016] A preparation method of Huashanshen Pingchuan Granules, comprising the steps of:

[0017] (1) Take Huashan ginseng and grind it into a coarse powder, use 7 mass times the volume percentage concentration of 85% ethanol aqueous solution to reflux extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 70 °C The relative density is 1.2, and the concentrated paste is obtained;

[0018] (2) Dilute the concentrated ointment with purified water according to the mass ratio of 1:1, add ammonia water to alkalinize the pH=9, obtain an alkalized dilution, extract 3 times with ethyl acetate of 2 times the volume of the alkalized dilution times, to obtain the extract, reclaim the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0019] (3) adding sucrose with 3 times the weight of the Huashan ginseng extract, mixing evenly, granulating, and d...

Embodiment 2

[0021] A preparation method of Huashanshen Pingchuan Granules, comprising the steps of:

[0022] (1) Take Huashan ginseng and grind it into a coarse powder, use 4 mass times the volume percentage concentration of 95% ethanol aqueous solution to reflux extract 3 times, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 80 ° C The relative density is 1.3, and the concentrated paste is obtained;

[0023] (2) Dilute the concentrated ointment with purified water at a ratio of 1:0.8 by mass, add ammonia water to make it alkaline to pH=11, obtain an alkalized dilution, and extract 3 times with ethyl acetate of three times the volume of the alkalized dilution times, to obtain the extract, reclaim the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0024] (3) Add starch with 5 times the mass of the Huashan ginseng extract, mix evenly, granulate, and dry...

Embodiment 3

[0026] A preparation method of Huashanshen Pingchuan Granules, comprising the steps of:

[0027] (1) Take Huashan ginseng and grind it into coarse powder, use 10 times by mass of 70% ethanol aqueous solution to reflux extract once, extract for 4 hours, filter the extract, reclaim ethanol from the filtrate, and concentrate to a relative density of 65°C. 1.03 to obtain a concentrated ointment; (2) dilute the concentrated ointment with purified water at a mass ratio of 1:1.5, add ammonia water to make pH = 8, and obtain an alkalized dilution, which is 0.5 times the volume of the alkalized dilution extracted with ethyl acetate 4 times to obtain the extract, recover the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0028] (3) Add dextrin with 1 times the mass of the Huashan ginseng extract, mix evenly, granulate, and dry to obtain.

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Abstract

The invention discloses a preparation method of radix physochlainae granules for relieving asthma. The preparation method comprises the following steps of (1) smashing radix physochlainae to form coarse powder, carrying out reflux extraction by using an ethanol water solution to obtain an extracting solution, filtering to obtain filtrate, recovering ethanol from the filtrate, and concentrating to obtain concentrated paste; (2) diluting the concentrated paste with purified water according to the mass ratio of 1:(0.8-1.5), adding ammonia water to alkalize to enable the pH value of the solution to be equal to 8-11 to obtain an alkalized diluent, extracting 2-4 times by using ethyl acetate which is 0.5-3 times as much as the volume of the alkalized diluent to obtain an extracting solution, recovering ethyl acetate, and volatilizing a water bath until no ethyl acetate smell to obtain a radix physochlainae extract; and (3) adding saccharose, starch or dextrin, uniformly mixing, granulating and drying to obtain the radix physochlainae granules for relieving asthma. Experiments prove that the radix physochlainae granules for relieving asthma, prepared by using the preparation method disclosed by the invention, have a favorable asthma relieving effect. The radix physochlainae granules for relieving asthma are high in effect taking speed, convenient to take, remarkable in curative effect and capable of simultaneously treating both symptoms and root causes, so that the requirements of extensive patients can be met. By using the preparation method, few labor hours are needed, and the transfer rate of effective components is high.

Description

technical field [0001] The invention belongs to the field of modernized traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Huashanshen Pingchuan Granules. Background technique [0002] Asthma is a widespread and reversible airway narrowing disease caused by bronchial hyperresponsiveness caused by allergens or other factors. The clinical manifestations are recurrent chest tightness, wheezing, dyspnea, cough and other symptoms. Before the attack, there are often aura symptoms such as nasal congestion, sneezing, and itchy eyes. In severe cases, severe dyspnea and hypoxemia may occur within a short period of time, threatening life. There are about 2000-3000 deaths from asthma in the United States every year, and there is an increasing trend. In 2004, the Global Initiative for Asthma Prevention (GINA) estimated that there were about 300 million cases in the world, the prevalence of asthma in children and adults was about 3.3%-29% and 1.2...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/16A61P11/06
CPCA61K9/1652A61K36/81A61K2236/333A61K2236/39
Inventor 刘丹佟永领王金磊刘梦妮
Owner 津药达仁堂集团股份有限公司第六中药厂
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