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Hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit and preparation method and detection method thereof

A technology for binding globin and hemoglobin, which is applied in the field of hemoglobin, hemoglobin-haptoglobin complex, transferrin combined detection kits and the fields of their preparation and detection, and can solve the problem of low positive coincidence rate of rectal cancer or colon cancer, lack of hemoglobin- Combined with the detection of globin complexes, etc., to improve the diagnostic accuracy and avoid confusion

Inactive Publication Date: 2015-04-15
HANGZHOU HUIYUANTAI MEDICAL DEVICES
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Problems solved by technology

For example, the Chinese invention patent application publication number is CN101965515A (announced on February 2, 2011) providing a method and device for detecting occult blood, including detecting transferrin and hemoglobin in GI samples, and detecting The amounts of transferrin and hemoglobin are compared with the respective predetermined values ​​of transferrin and hemoglobin, thereby topping the bleeding from the GI and providing detection of transferrin and hemoglobin using a lateral flow sandwich immunoassay device , the technical scheme lacks the detection of hemoglobin-haptoglobin complex, and the positive coincidence rate for rectal or colon cancer is low

Method used

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  • Hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit and preparation method and detection method thereof
  • Hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit and preparation method and detection method thereof
  • Hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit and preparation method and detection method thereof

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Embodiment Construction

[0052] The present invention will be further described below with reference to the accompanying drawings and examples, but it should be pointed out that the joint detection kit of the present invention is not limited to this specific shape or structure. Those skilled in the art can obviously understand that the following explanations can be directly applied to test strips of other types or structures not specified herein even without any adjustment or modification.

[0053] Such as Figure 1-Figure 7 As shown, a combined detection kit for hemoglobin, hemoglobin-haptoglobin complex, and transferrin comprises an immunological test strip 6, a chemical test paper 20 (o-toluidine test paper), an upper jam 1 and a lower jam 2.

[0054] The surface of the upper casing of the joint inspection kit is designed with a circular or oval sampling hole 3, an observation window 4, a chemical test paper observation window 17, an ID record 18, and a two-dimensional code 19. The lower casing 2 i...

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Abstract

The invention provides a hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit. The hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit comprises an upper shell, a lower shell, an immunostrip, test paper and the like; a gold-labeled composite containing a hemoglobin monoclonal antibody, a hemoglobin-haptoglobin composite monoclonal antibody and a transferrin monoclonal antibody is scribed on a nitrocellulose membrane; 3 test lines, a quality control line (15) and a gold-labeled composite membrane scribing line (8) are arranged on the nitrocellulose membrane in parallel. The invention further provides a preparation method and a detection method of the hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit. The hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit is convenient and simple in operation, stable in performance and accurate in result, has a relatively good reference value for early diagnosis and identification of colorectal cancer or colon cancer tumor or other tumors with lower gastrointestinal bleeding symptoms in clinic, significantly improves the positive detection rate of digestive hemorrhagic diseases, is suitable for clinical hospital examination and household self-examination, and provides measures for large-scale general examination of such diseases.

Description

technical field [0001] The invention belongs to the technical field of clinical in vitro diagnostic reagents, specifically a hemoglobin, hemoglobin-haptoglobin complex, and transferrin joint detection kit, which applies the principle of immunology, lateral flow chromatography and chemical o-toluidine chromogenic method, By detecting hemoglobin, hemoglobin-haptoglobin complex and transferrin in human feces, the symptoms of lower gastrointestinal bleeding can be found, and early diagnosis of lower gastrointestinal tumors such as rectal cancer or colon cancer can be performed. Background technique [0002] Hemoglobin (Hb, Hemoglobin) in feces, also known as fecal occult blood (FOB, Fecal Occult Blood), is currently clinically regarded as one of the tumor markers for the diagnosis of rectal cancer and colon cancer. Haptoglobin (Hp, Haptoglobin, also known as haptoglobin or globulin) is widely present in the blood and other body fluids of humans and many mammals, and the content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/531G01N33/543
CPCG01N33/721G01N33/531G01N33/57446G01N33/57484G01N33/6893
Inventor 谢福文詹特斌丁超
Owner HANGZHOU HUIYUANTAI MEDICAL DEVICES
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