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Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis

A technology for autoimmunity and thyroiditis, applied in the field of traditional Chinese medicine, can solve the problems of affecting the appearance, unclear drug effect substances, and low drug bioavailability.

Inactive Publication Date: 2015-04-22
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1) Traditional Chinese medicine compound prescriptions are mostly prepared from 10 to 40 raw materials. There are many types of drugs and the effective substances are not clear. Therefore, most of them can only be administered orally, and the bioavailability of drugs administered orally is low, resulting in shortage of medicinal material resources waste;
[0009] 2) At present, very few traditional Chinese medicine compound prescriptions for the treatment of autoimmune thyroiditis can be prepared from five raw materials, but there are also problems with unclear effective substances, and they are only prepared as oral preparations for administration, with low bioavailability;
[0010] 3) At present, very few traditional Chinese medicine compound prescriptions for the treatment of autoimmune thyroiditis can be prepared as externally applied drugs, but due to the consideration of drug release speed and drug loading, they can only be prepared as simple paste mixtures to apply to the affected area. The adhesion is not strong, it is inconvenient for the patient to administer the drug, and it affects the appearance, and the patient's compliance is poor

Method used

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  • Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Traditional Chinese medicine cataplasm for treating autoimmune thyroiditis and its preparation

[0039] Raw materials: Fritillaria 500g, Chinese yam 220g, Radix Radix 90g, Albizia Julibrissin 120g, Haitian melon 60g.

[0040] Pharmaceutical excipients: carbomer 940 79.2g, sodium carboxymethylcellulose 118.8g, diatomaceous earth 198g, aluminum dihydroxyglycinate 4.95g, citric acid 6.93g, polyvinylpyrrolidone 103.95, decylmethyl sulfoxide 99g, Polyethylene glycol 200 79.2g, glycerin 118.8g.

[0041] Preparation:

[0042] 1) Peel the yam, cut it into thin slices with a thickness of 2mm, dry it at 50°C, crush it, and pass it through a 100-mesh sieve to get yam powder;

[0043] 2) Add ethanol with a concentration of 70% to the medicinal material powder obtained in step 1) according to the ratio of solid to liquid 1:6, extract in a constant temperature water bath under reflux for 4 hours at 60°C, and filter while it is hot to obtain the yam extract;

[0044] 3)...

Embodiment 2

[0051] Example 2 Traditional Chinese medicine cataplasm for treating autoimmune thyroiditis and its preparation

[0052] Raw materials: Fritillaria 540g, Yam 180g, Radix Radix 70g, Albizia julibrissin 90g, Haitian melon 90g.

[0053] Pharmaceutical excipients: carbomer 940 87.3g, sodium carboxymethylcellulose 126.1g, diatomaceous earth 203.7g, aluminum dihydroxyglycinate 3.88g, citric acid 5.82g, polyvinylpyrrolidone 106.7, decylmethyl sulfoxide 106.7 , polyethylene glycol 200 87.3g, glycerin 135.8g.

[0054] Preparation:

[0055] 1) Peel the yam, cut it into thin slices with a thickness of 2mm, dry it at 50°C, crush it, and pass it through a 100-mesh sieve to get yam powder;

[0056] 2) Add ethanol with a concentration of 70% to the medicinal material powder obtained in step 1) according to the ratio of solid to liquid 1:6, extract in a constant temperature water bath under reflux for 4 hours at 60°C, and filter while it is hot to obtain the yam extract;

[0057] 3) Rem...

Embodiment 3

[0064] Example 3 Traditional Chinese medicine cataplasm for treating autoimmune thyroiditis and its preparation

[0065] Raw materials: Fritillaria 460g, Chinese yam 200g, Radix isatidis 60g, Albizia Julibrissin 140g, Haitian melon 70g.

[0066] Pharmaceutical excipients: carbomer 940 74.4g, sodium carboxymethylcellulose 102.3g, diatomaceous earth 176.7g, aluminum dihydroxyglycinate 3.72g, citric acid 6.51g, polyvinylpyrrolidone 102.3, decylmethyl sulfoxide 97.65 , polyethylene glycol 200 69.8g, glycerin 102.3g.

[0067] Preparation:

[0068] 1) Peel the yam, cut it into thin slices with a thickness of 2mm, dry it at 50°C, crush it, and pass it through a 100-mesh sieve to get yam powder;

[0069] 2) Add ethanol with a concentration of 70% to the medicinal material powder obtained in step 1) according to the ratio of solid to liquid 1:6, extract in a constant temperature water bath under reflux for 4 hours at 60°C, and filter while it is hot to obtain the yam extract;

[00...

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Abstract

The invention discloses a traditional Chinese medicine cataplasma for treating autoimmune thyroiditis, and a preparation method of the traditional Chinese medicine cataplasma. The effective components of the traditional Chinese medicine cataplasma are prepared from the following raw materials in parts by weight: 45-55 parts of thunberg fritillary bulb, 15-25 parts of Chinese yam, 5-10 parts of radix isatidis, 8-15 parts of albizia flower and 5-10 parts of acaudina molpadioides. The invention further discloses a preparation method of the traditional Chinese medicine cataplasma. An experiment result proves that the traditional Chinese medicine cataplasma disclosed by the invention has a good treatment effect on the autoimmune thyroiditis, is good in transdermal absorption effect, has the advantages of rapidly releasing medicines and rapidly playing medicine effects, and has good clinical application value; and metabolism of the medicine in gastrointestinal tracts can be avoided.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine cataplasm for treating autoimmune thyroiditis and a preparation method thereof. Background technique [0002] Autoimmune thyroiditis (Autoimmune thyroiditis) is a relatively common clinical autoimmune disease, also known as Hashimoto's disease, chronic lymphocytic thyroiditis, lymphatic goiter. The etiology of this disease is unknown, the pathogenesis is complicated, the onset is slow, and the course of disease is long. Patients often present symptoms such as diffuse enlargement of the thyroid gland. Serological tests showed elevated levels of thyroid autoantibodies and changes in thyroid function. The incidence of the disease is second only to hyperthyroidism, accounting for about 20% of thyroid diseases. The incidence rate of this disease in my country is about 0.3-1.5 / 1000, and most of them are female patients aged 30-50...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/70A61P5/14A61K35/616
Inventor 王中雨王垚
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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