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Application of rhynchophylline in preparation of medicine for resisting cerebral vascular contraction

A technology of rhynchophylline and cerebrovascular, which is applied in the field of application of rhynchophylline in the preparation of anti-cerebrovascular constriction drugs, and can solve problems such as no research reports on the effect of rhynchophylline

Inactive Publication Date: 2015-04-29
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Current studies have shown that rhynchophylline can relax various types of blood vessels, including thoracic aorta, mesenteric artery, etc., but there is no research report on the effect of rhynchophylline on resistance blood vessels in living animals

Method used

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  • Application of rhynchophylline in preparation of medicine for resisting cerebral vascular contraction
  • Application of rhynchophylline in preparation of medicine for resisting cerebral vascular contraction
  • Application of rhynchophylline in preparation of medicine for resisting cerebral vascular contraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Tablet preparation

[0084] Rhynchophylline is used as the active ingredient of the drug, added to the drug carrier, and prepared according to the conventional technology of pharmacy, such as the following preparation method:

[0085] 10mg of rhynchophylline, 200mg of starch, 100mg of powdered sugar, appropriate amount of magnesium stearate, using starch paste as a binder, mixing, granulating, air-drying, sizing, and tableting to obtain tablets.

[0086] Tablet stability test:

[0087] The tablet prepared by the above method was placed in an incubator at 40° C., and observed after 3 months, its appearance and color did not change in any way.

Embodiment 2

[0089] Preparation of hard capsules

[0090] Rhynchophylline is used as the active ingredient of the drug, added to the drug carrier, and prepared according to the conventional technology of pharmacy, such as the following preparation method:

[0091] 10mg rhynchophylline, 200mg starch, 100mg powdered sugar, appropriate amount of magnesium stearate, starch paste as binder, mixed, granulated, air-dried, granulated, and packed into capsules.

Embodiment 3

[0093] Preparation of soft capsules

[0094] Rhynchophylline is used as the active ingredient of the drug, added to the drug carrier, and prepared according to the conventional technology of pharmacy, such as the following preparation method:

[0095]Rhynchophylline 10mg, soybean oil 100mg, polyethylene glycol 100mg, gelatin as the capsule shell, prepared into soft capsules.

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Abstract

The invention relates to a new application of a medicine and particularly relates to an application of rhynchophylline in preparation of a medicine for resisting cerebral vascular contraction.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular to the application of rhynchophylline in the preparation of a medicine for resisting cerebral vasoconstriction. Background technique [0002] Small vessel disease (SVD) is one of the causes of ischemic stroke. Over the past ten years, studies have found that cerebral small vessel disease is closely related to many diseases such as stroke, cognitive and emotional disorders, gait instability and aging, so it has attracted more and more attention from scholars. The theme of World Stroke Day in 2008 is "Minor Stroke , Big Trouble" (Little Strokes, Big Trouble). [0003] Cerebral small vessel disease refers to a group of diseases whose pathological changes mainly involve small intracranial vessels, including arterioles, arterioles, precapillaries, and venules. Arterial small vessels include arterioles (luminal diameter 100-400 μm, with an inner elastic plate and a middle layer compose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/438A61P9/10A61P9/00
CPCA61K31/438
Inventor 韩晶岩郝会峰刘利梅高远生刘育英
Owner TIANJIN TASLY PHARMA CO LTD
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