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For the manufacture of no/n for the medical field 2 gaseous mixture method

A technology of gaseous mixtures and mixtures, applied in the direction of mixing methods, gas and gas/steam mixing, nitrogen compounds, etc., can solve problems such as high toxicity

Active Publication Date: 2018-02-06
AIR LIQUIDE SANTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the NO present in the resulting final NO / nitrogen mixture 2 Impurities are a serious problem at the medical level because NO 2 Highly toxic when inhaled by patients even in very small doses - a few ppm by volume

Method used

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  • For the manufacture of no/n for the medical field <sub>2</sub> gaseous mixture method
  • For the manufacture of no/n for the medical field <sub>2</sub> gaseous mixture method
  • For the manufacture of no/n for the medical field <sub>2</sub> gaseous mixture method

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Embodiment Construction

[0038] figure 1 Schematically shows an embodiment of the production method according to the invention, which produces no or almost no NO 2 NO / N of impurities 2 Gaseous mixtures, e.g. NO / N containing about 4% NO and nitrogen as remainder 2 gaseous mixture.

[0039] According to the method, the following successive steps are performed:

[0040] - (at 31) feeding impure nitrogen with the following composition: O 2 ≤50ppmv, CO≤5ppmv, CO 2 ≤300ppmv,H 2 O≤67ppmv, and N as remainder 2 (about 99.5%v)

[0041] - Purging of gaseous nitrogen containing the above-mentioned impurities is performed by the following steps:

[0042] i) (at 32) contacting the impure nitrogen with, for example, a nickel catalyst to eliminate or convert at least a portion of the O 2 type impurities, especially by converting them into water vapor or H 2 O,

[0043] ii) (at 33) contacting the nitrogen purified in sub-step i) with a molecular sieve such as 10A° zeolite to eliminate at least a portion of ...

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Abstract

The invention relates to a method for manufacturing NO / N 2 A method for a gaseous mixture, comprising the steps of: achieving a process comprising at least O 2 Purification of impure gaseous nitrogen from impurities of the type, and obtaining O containing a NO content of less than 20% by volume and a proportion of less than 5ppmv 2 Type impurity and H in proportion less than 40ppmv 2 A mixture of NO and pure nitrogen as an O-type impurity. NO / nitrogen mixtures are subject to make-up dilution with pure nitrogen. This NO / nitrogen mixture can be used by inhalation to treat pulmonary vasoconstriction in adults or children, especially neonates with primary pulmonary hypertension or patients undergoing cardiac surgery.

Description

technical field [0001] The invention relates to a method for manufacturing NO / N 2 A method of encapsulating a gaseous mixture and subsequently enclosing it in a container, in particular one or more gas cylinders. Background technique [0002] NO / N 2 The gaseous mixture is commonly used to treat pulmonary vasoconstriction in adults, children and especially neonates with primary pulmonary hypertension and in patients undergoing cardiac surgery. [0003] These NO / N 2 The mixture is usually enclosed in cylinders made of steel and aluminum and contains 100 to 1000 ppm by volume of NO and nitrogen (N 2 ). These bottles typically have a water equivalent capacity of 2 to 50 liters. [0004] Encapsulation - that is to say the bottling of these mixtures - is done at the Gas Bottling Centre. For this, one or more mixtures of NO and nitrogen are produced until the desired concentration of NO in nitrogen is obtained. [0005] However, it can happen that the NO / nitrogen mixtures th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/02B01F23/10
CPCA61M16/12C01B21/24A61M2202/0266A61M2202/0275A61M2202/0283A61M2207/00C01B2210/0006C01B2210/001C01B2210/0045C01B2210/0062C01B21/0422C01B21/0433C01B21/045A61M16/107A61K33/00A61K2300/00
Inventor P·德 维尔默尔L·勒古
Owner AIR LIQUIDE SANTE
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