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A kind of sterilization method of traditional Chinese medicine preparation

A technology of traditional Chinese medicine preparation and sterilization method, applied in directions such as heating, can solve the problems of reducing curative effect, drug production risk, and high sterilization cost, and achieve the effects of avoiding secondary pollution, good sterilization effect, and stable sterilization effect.

Active Publication Date: 2018-08-31
SUNFLOWER PHARMA GRP CHONGQING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For preparations containing toxic medicinal materials such as Aconitum Aconitum and Aconitum Aconitum in the prescription, if high-temperature steam sterilization is used in industrial production, it will not only pollute the sterilization equipment and production environment, but also bring risks to drug production, and microbial contamination will still occur in the later extraction process , and the production process is more complicated
At the same time, for the product, high temperature sterilization will affect the chemical composition of the medicinal materials and reduce the curative effect; while the use of Co60 irradiation sterilization requires a special site, a long time, high sterilization costs, and has an impact on the chemical composition; the use of extract filtration Method for sterilization, easy to block during filtration, unable to filter large-capacity traditional Chinese medicine extracts, unstable sterilization effect, high cost of consumables

Method used

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  • A kind of sterilization method of traditional Chinese medicine preparation
  • A kind of sterilization method of traditional Chinese medicine preparation
  • A kind of sterilization method of traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The prescription of traditional Chinese medicine preparations is: Soushanhu 31.7g, Yellow Rhododendron root 63.3g, Raw Aconitum 63.3g, Raw Aconitum 63.3g, Raw Araceae 63.3g, Raw Pinellia 63.3g, Camphor 10.1g, Menthol 1.7g. Production method: Except for camphor and menthol, the other six kinds of medicinal materials are crushed into coarse powder, according to the percolation method of liquid extract and extract item in "Chinese Pharmacopoeia", use 65% ethanol as solvent, soak for 48 hours and then carry out percolation , collect about 2250ml of the first decant liquid, set aside, continue to collect the filtrate, concentrate until an appropriate amount is added to the initial decant liquid, after mixing, add camphor, stir to dissolve the menthol, adjust the total amount to 3000ml, stand still, filter, and obtain ethanol Content is 50-60% ethanol extract.

[0022] Prepare 2000L of ethanol extract according to the above method, heat to 50°C, keep warm for 12 hours, take s...

Embodiment 2

[0025] The prescription of traditional Chinese medicine preparations is: Soushanhu 31.7g, Yellow Rhododendron root 63.3g, Raw Aconitum 63.3g, Raw Aconitum 63.3g, Raw Araceae 63.3g, Raw Pinellia 63.3g, Camphor 10.1g, Menthol 1.7g. Production method: Grind six kinds of medicinal materials into coarse powder, adopt the percolation method of liquid extract and extract item, use 65% ethanol as solvent, and carry out percolation after immersion for 48 hours, collect about 2250ml of the initial drainage liquid, set aside, continue Collect the filtrate, concentrate to an appropriate amount and add the primary filtrate, after mixing, adjust the total amount to 3000ml, let it stand, and filter to obtain an ethanol extract with an ethanol content of 50-60%.

[0026] Prepare 2000L of ethanol extract according to the above-mentioned method, heat to 60 ℃, keep warm for 9 hours, add camphor and menthol and stir to make it dissolve, filter, filtrate sampling, measure the total number of bacter...

Embodiment 3

[0029] The formula and production method of the Chinese medicine preparation are the same as in Example 1.

[0030] Take 2000L of ethanol extract, heat it to 70°C, keep it warm for 6 hours, take samples, measure the total number of bacteria and Staphylococcus aureus in the heat-preserved and sterilized samples and the stock solution, and measure the alkaloid content. Results The bacteria and Staphylococcus aureus in the heat preservation sterilized samples were all killed, and the alkaloid content before and after sterilization was similar. See the table below:

[0031] project

[0032]

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Abstract

The invention provides a sterilization method for a traditional Chinese medicine preparation. The traditional Chinese medicine preparation is an alcohol extracting solution. The sterilization method comprises the following steps: heating the alcohol extracting solution, preserving the heat and sterilizing. The sterilization method is simple and convenient, practical, efficient, and capable of completely solving a problem that microorganisms in the drug production are unqualified, and avoiding active ingredients in the medical materials from losing.

Description

Technical field: [0001] The invention relates to a sterilization method, in particular to a sterilization method of traditional Chinese medicine preparations. Background technique [0002] Traditional Chinese medicine has various components and complex components, and usually contains a large number of bacteria, and often contains pathogenic bacteria. In actual production, the medicinal solution prepared by normal temperature extraction often has uncountable bacteria, excessive bacteria and contains pathogenic bacteria, resulting in unqualified products. In order to make the microbial indicators meet the standard requirements, methods such as high-temperature steam sterilization of medicinal materials, Co60 irradiation sterilization, and filtration sterilization of extracts are often used. For preparations containing toxic medicinal materials such as Aconitum Aconitum and Aconitum Aconitum in the prescription, if high-temperature steam sterilization is used in industrial pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L2/04
Inventor 聂进涂其军何亮
Owner SUNFLOWER PHARMA GRP CHONGQING CO LTD
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