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Automatic analysis device

By dividing the pressure waveform in the automatic analysis device and comparing it with the reference, the problem of reduced dispensing volume caused by bubbles and highly viscous samples in the dispensing accuracy detection is solved, the dispensing accuracy and efficiency are improved, and the reliability of the device is enhanced.

Active Publication Date: 2015-04-29
HITACHI HIGH TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, it is required to accurately aspirate and discharge micro-sample of less than 2 μL, but at this time, the diameter of the sample probe should be made thinner

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Before describing Embodiment 1 of the present invention, the basic idea of ​​Embodiment 1 will be described.

[0050] When the dispensing abnormality of the sample or reagent is caused by multiple reasons, there are two types of information, that is, the known information clearly known at the stage of determining the design of the automatic analyzer and the analysis parameters, and the information that differs depending on the characteristics of the sample or reagent variable information.

[0051] Known information that is clearly known includes the relationship between the dispensed amount and the driving time of the syringe, a clogging detection discrimination algorithm, and the like in the design of an automatic analyzer. In addition, when setting analysis parameters, the type of sample (urine, serum, whole blood, etc.), sampling position, and dispensing volume are known in advance, and the viscosity of the reagent, the presence or absence of surfactant, and Aspirat...

Embodiment 2

[0167] In the method for judging the dispensing operation in Embodiment 1 of the present invention, the pressure change during dispensing and discharging of the sample is divided into four steps (pressure measurement step, analysis step, judgment step, and comprehensive judgment step), and the The pressure change in each process was analyzed using an approximate formula. Then, an abnormality in the process is detected based on the parameters of the above-mentioned approximation formula. The judgment combining each process is called comprehensive judgment, and the abnormality detection of each process becomes the basis.

[0168] As a method different from Embodiment 1 of the present invention, there is a method of performing comprehensive determination mathematically and statistically based on a plurality of data.

[0169] Embodiment 2 of the present invention is based on the above-mentioned multiple data, and the method of mathematically and statistically comprehensively judg...

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PUM

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Abstract

This automatic analysis device can detect not only dispensing probe clogging and air sucking but also reductions in dispensing quantities caused by foam films, bubbles, and high viscosity samples. The operating times for sucking in and discharging of a sample or reagent by the probe are each divided into a plurality of times, and parameters are calculated by fitting a pressure waveform that is detected for each time division to an approximation expression. The calculated parameters are compared to parameters for the case of normal dispensing, and the absence or presence of dispensing abnormalities is determined for each time division. Thus, an automatic analysis device can be achieved in which the absence or presence of abnormalities peculiar to each time division can be discriminated and in which abnormalities that were difficult to discriminate with conventional technology can be determined.

Description

technical field [0001] The invention relates to an automatic analysis device for qualitative / quantitative analysis of biological samples such as blood and urine. Background technique [0002] The automatic analysis device discharges a certain amount of sample and a certain amount of reagent into the reaction container, and makes them mix to generate a reaction. The sample dispensing mechanism of the automatic analyzer is a mechanism for automatically dispensing a liquid, for example, dispensing a small amount of a sample such as serum or urine into a plurality of reaction containers. The sample dispensing mechanism includes: a long and thin metal or plastic probe, a tube connected to the probe, and a dispensing syringe at the tip of the tube. By reciprocating the plunger of the dispensing syringe, the pressure in the pipe is changed, thereby aspirating and discharging the sample. [0003] Usually, a liquid (system water) is filled in a pipe including a sample probe and a d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10G01N35/00
CPCG01N35/1016G01N2035/1018Y10T436/11G01N35/00623G01N35/00871G01N2035/00891
Owner HITACHI HIGH TECH CORP