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Pharmaceutical composition for resisting diabetes activity and preparation method thereof

An anti-diabetic and composition technology, applied in the field of anti-diabetic active pharmaceutical composition and its preparation, can solve the problems of no olive leaf extract, simple and rough extraction process, and unclear active components

Inactive Publication Date: 2015-05-20
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction process is simple and rough, the active components are not clear, and the mechanism of action is unclear
At the same time, there is no report that the olive leaf extract is used alone as a drug

Method used

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  • Pharmaceutical composition for resisting diabetes activity and preparation method thereof
  • Pharmaceutical composition for resisting diabetes activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of Olive Leaf Extract Tablets

[0036] Weigh 100 g of olive leaf extract, 80 g of starch, and 25 g of β-cyclodextrin through a 80-mesh sieve, mix them evenly, add a 50% ethanol aqueous solution to make a soft material, and pass through a 20-mesh sieve to obtain wet granules. Dry at 60°C for 2 hours, add 0.5 g of microcrystalline cellulose and 1 g of magnesium stearate, mix well, die and press into tablets to obtain tablets, 0.3 g / tablet, 650 pieces.

Embodiment 2

[0038] Preparation of Olive Leaf Extract Tablets

[0039] Weigh 100 g of olive leaf extract, 30 g of starch, and 10 g of β-cyclodextrin through a 80-mesh sieve, mix them evenly, add a 50% ethanol aqueous solution to make a soft material, and pass through a 20-mesh sieve to obtain wet granules , dried at 65°C for 1.5 hours, added 1 g of microcrystalline cellulose, 1 g of talc, and 1 g of magnesium stearate, mixed evenly, punched and pressed into tablets to obtain tablets, 0.5 g / tablet, 280 pieces.

Embodiment 3

[0041] Preparation of Olive Leaf Extract Capsules

[0042]Weigh 100g of olive leaf extract, 80g of starch, and 20g of β-cyclodextrin through a 80-mesh sieve, mix well, add a suitable amount of 50% ethanol aqueous solution to make a soft material, pass through a 20-mesh sieve to obtain wet granules, and pass through a 20-mesh sieve to obtain wet granules. Dried for 2 hours, granulated, packed into hard capsules, obtained capsules, 0.3g / capsule, 650 capsules.

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Abstract

The invention discloses a pharmaceutical composition for resisting diabetes activity and a preparation method thereof. The composition is composed of an olea europaea leaf extract and a carrier, wherein the carrier is selected from starch, beta-cyclodextrin, a talcum powder, microcrystalline cellulose and magnesium stearate. In-vitro cell glucose consumption experiments prove that the composition increases the glucose consumption amount of model cells and has obvious hypoglycemic effect. In-vivo animal experiments prove that the composition has a significant role in lowering blood glucose on mesoxyalyurea induced hyperglycemic mice.

Description

technical field [0001] The invention relates to a pharmaceutical composition with antidiabetic activity and a preparation method thereof, which can be used for treating diabetes. Background technique [0002] Diabetes is a common endocrine and metabolic disease. The survey in 1980 showed that the prevalence rate in my country accounted for 0.67% of the population. According to the International Diabetes Federation (IDF), the number of diabetic patients in India was 50.8 million in 2010 and will rise to 87 million by 2030. The above facts show that with the improvement of people's social and economic life, the number of diabetic patients (especially type Ⅱ) is increasing rapidly, which cannot be ignored. [0003] Olive leaves are Oleaceae plant Oleaceae Oleaceae ( Olea europaea L.) dried leaves. There are more than 100 olive varieties introduced in my country, mainly distributed in Gansu, Sichuan, Chongqing, Shaanxi, Fujian, Jiangsu, Guangdong and other places. Olive le...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61K9/16A23L1/29A61P3/10A23L33/00
Inventor 孙小明邸多隆
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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