Extraction technology for extracting hypotensive substances from rapeseed meal

An extraction process and rapeseed meal technology are applied in the field of extraction process for extracting antihypertensive substances from rapeseed meal, which can solve problems such as inability to eliminate blood pressure, and achieve the effects of significant antihypertensive effect, low price and high content of active ingredients.

Inactive Publication Date: 2015-05-27
THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the prevention and treatment of hypertension and its complications have important clinical significance. Hypertension is mostly treated with drugs. reaction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An extraction process for extracting a hypotensive substance from rapeseed meal, said extraction process comprising the following steps:

[0028] Step 1: Material selection: select 100 kg of dried rapeseed meal;

[0029] Step 2: First water extraction: Put the rapeseed meal obtained in step 1 into a multifunctional extraction tank, then add 1000 kg of purified water, heat to boiling, and decoct for 1.5 hours;

[0030] Step 3: Filtration: Discharge the extract after decoction in step 2 from the filter of the multifunctional extraction tank to obtain the first extract;

[0031] Step 4: The first water extraction: add 1000 kg of purified water to the dregs filtered in step 2, heat to boiling, and decoct for 1.5 hours;

[0032] Step 5: Re-filter: the extract after decoction in step 4 is discharged again from the filter of the multifunctional extraction tank to obtain the second extract;

[0033] Step 6: Combine: Combine the first extraction solution and the second extraction solution ...

Embodiment 2

[0046] An extraction process for extracting a hypotensive substance from rapeseed meal, said extraction process comprising the following steps:

[0047] Step 1: Material selection: select 200 kg of dried rapeseed meal;

[0048] Step 2: First water extraction: Put the rapeseed meal obtained in Step 1 into a multifunctional extraction tank, then add 2000 kg of purified water, heat to boiling, and decoct for 1.5 hours;

[0049] Step 3: Filtration: Discharge the extract after decoction in step 2 from the filter of the multifunctional extraction tank to obtain the first extract;

[0050] Step 4: The first water extraction: Add 2000 kg of purified water again to the dregs filtered in step 2, heat to boiling, and decoct for 1.5 hours;

[0051] Step 5: Re-filter: the extract after decoction in step 4 is discharged again from the filter of the multifunctional extraction tank to obtain the second extract;

[0052] Step 6: Combine: Combine the first extraction solution and the second extraction sol...

Embodiment 3

[0065] An extraction process for extracting a hypotensive substance from rapeseed meal. The extraction process includes the following steps:

[0066] Step 1: Material selection: select 50 kg of dried rapeseed meal;

[0067] Step 2: First water extraction: Put the rapeseed meal obtained in Step 1 into a multifunctional extraction tank, then add 500 kg of purified water, heat to boiling, and decoct for 1.5 hours;

[0068] Step 3: Filtration: discharge the extract after decoction in step 2 from the filter of the multifunctional extraction tank to obtain the first extract;

[0069] Step 4: The first water extraction: add 500 kg of purified water to the dregs filtered in step 2, heat to boiling, and decoct for 1.5 hours;

[0070] Step 5: Re-filter: the extract after decoction in step 4 is discharged again from the filter of the multifunctional extraction tank to obtain the second extract;

[0071] Step 6: Combine: Combine the first extraction solution and the second extraction solution togeth...

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PUM

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Abstract

The invention relates to an extraction technology for extracting hypotensive substances from rapeseed meal. The technology comprises the following steps: selecting materials; extracting, carrying out high-speed centrifugation, adsorbing oil, removing impurities and eluting; and carrying out vacuum concentration and low-temperature drying to obtain the hypotensive substances, wherein the rapeseed meal is a residue after oil is squeezed from rapeseeds. The technology is wide in raw material source and low in price. According to the extraction technology, water-soluble components in the rapeseed meal are extracted with low-cost water; oil is adsorbed with kieselguhr to be subjected to degreasing treatment, and is subjected to high-speed centrifugal degreasing; impurities are removed with macroporous resin D941; hypotensive components in a D941 resin column effluent are adsorbed with DM21 macroporous resin; the impurity components are washed off with a water solution and 20% ethanol solution; the hypotensive components are eluted with 50% ethanol solution; and the amount of the 50% ethanol solution is low, so that the cost is reduced; and the obtained hypotensive substances are high in effective component content and significant in hypotensive treatment effect.

Description

Technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to an extraction process, in particular to an extraction process for extracting a hypotensive substance from rape meal. Background technique [0002] Hypertension is an important factor that causes cardiovascular and cerebrovascular diseases, especially middle-aged and elderly people. With the accelerating process of aging in my country, hypertension is currently recognized as one of the most serious diseases that endanger human health. Hypertension refers to an independent disease whose main clinical manifestations are systemic arterial systolic blood pressure or diastolic blood pressure higher than the normal range. It is one of the important risk factors for myocardial infarction and cerebrovascular events. At present, the prevalence of hypertension in the population in my country is still increasing. According to the World Health Organization, by 2020, non-communicable di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P9/12A61K131/00
Inventor 刘长河王艳艳任孝德郭荣华马开刘方洲李开言周红艳王晓丽
Owner THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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