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Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition

A technology of alcoholic liver disease and composition, which is applied in the field of pharmaceutical composition for the treatment of alcoholic liver disease, can solve the problem that the active ingredient extract of a single drug is in the animal experiment research stage, and achieve shortening time for sobering up, easy to carry and take, significant effect

Inactive Publication Date: 2015-05-27
泸州医学院附属中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For ADL, traditional Chinese medicine treatment mainly adopts classification theory and special prescription treatment, and the application of the active ingredient extract of single medicine is still in the stage of animal experiment research

Method used

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  • Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for treating alcoholic liver diseases as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 pharmaceutical granules of the present invention

[0026] [Prescription] Gehua 215g, Codonopsis 161g, Atractylodes macrocephala 107g, Poria cocos 107g, Bupleurum 107g, white peony root 161g, salvia miltiorrhiza 161g, knotweed 161g, Alisma 161g, hawthorn (raw) 161g, yellow grass 161g, dulcis dulcis 161g, Licorice 54g, dextrin 800g; make 1000g

[0027] [Preparation method] The above thirteen flavors, kudzu flower and salvia miltiorrhiza are crushed into coarse powder, soaked with 8 times the amount of 60% ethanol for 12 hours, percolated, collected percolated liquid, recovered ethanol, concentrated into liquid extract; dregs and the rest Codonopsis and other eleven herbs plus 12 times the prescription amount, soaked in water for 1 hour, decocted 3 times, 1 hour each time, combined the decoction, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.02-1.05 (80 ° C), static Leave it for 12 hours, take...

Embodiment 2

[0028] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0029] Take raw materials: Pueraria 172g, Codonopsis 128.8g, Atractylodes macrocephala 85.6g, Poria cocos 85.6g, Bupleurum 85.6g, white peony root 128.8g, salvia miltiorrhiza 128.8g, knotweed 128.8g, Alisma 128.8g, hawthorn 128.8g, yellow grass 128.8g, 128.8g Hovenia dulcis, 43.2g licorice; extract by the method of Example 1, granulate, pack into capsules to obtain capsules.

Embodiment 3

[0030] The preparation of embodiment 3 medicine oral liquid of the present invention

[0031] Take raw materials: Pueraria 258g, Codonopsis 193.2g, Atractylodes macrocephala 128.4g, Poria cocos 128.4g, Bupleurum 128.4g, Paeoniae Alba 193.2g, Salvia miltiorrhiza 193.2g, Polygonum cuspidatum 193.2g, Alisma 193.2g, hawthorn 193.2g, and yellow grass 193.2g, 193.2g Hovenia dulcis, 64.8g licorice, after extracting by the method of Example 1, are prepared into oral liquid.

[0032] Prove the beneficial effect of the present invention by concrete clinical test below.

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Abstract

The invention provides a pharmaceutical composition for treating alcoholic liver diseases. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 172-258 parts of flower of kudzuvine, 128.8-193.2 parts of root of codonopsis pilosula, 85.6-128.4 parts of bighead atractylodes rhizome, 85.6-128.4 parts of poria cocos, 85.6-128.4 parts of bupleurum, 128.8-193.2 parts of white peony root, 128.8-193.2 parts of salviae miltiorrhizae, 128.8-193.2 parts of polygonum cuspidatum, 128.8-193.2 parts of rhizoma alismatis, 128.8-193.2 parts of hawthorn fruit, 128.8-193.2 parts of penthorum chinense pursh, 128.8-193.2 parts of hovenia dulcis thumb and 43.2-64.8 parts of liquorice. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition disclosed by the invention is used for treating the diseases caused by alcoholic abuse and dependency, such as mild alcoholic injury, alcoholic fatty liver and alcoholic hepatitis, has good effects of dispelling the effects of alcohol, protecting the liver and lowering lipid and is obvious in curative effect of treating the alcoholic liver diseases. In addition, the medicine can obviously shorten the alcohol effect dispelling time by about 2 hours and is stable and reliable in drug effect and convenient to carry and take, and a novel selection is provided for clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating alcoholic liver disease, which belongs to the field of medicines. Background technique [0002] Alcoholic liver disease (ALD) is liver damage and a series of pathological changes caused by long-term heavy drinking. According to the Guidelines for the Diagnosis and Treatment of Liver Diseases, ALD is clinically divided into five different degrees of lesions: mild ALD, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, and alcoholic liver cirrhosis. ALD is the leading cause of liver cirrhosis in Western countries and one of the ten most common causes of death. In my country, with the continuous improvement of people's living standards, the increase of social communication and the increase of work pressure, etc., the number of alcoholics is also increasing year by year. According to the survey data, the incidence of ALD is increasing year by year in my country, and it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P1/16A61P39/02
Inventor 魏嵋李志蒲清荣汪静米绍平刘鹏张光海王晓栋李波刘菊容朱晓宁
Owner 泸州医学院附属中医医院
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