Aerosol precursor containing pharmacodynamic ingredients of Chuanbei Pipa syrup and method for dispersing aerosol precursor into nano-scale frog drops

A technology of Chuanbei loquat and medicinal components, which is applied in the field of aerosol precursors, can solve the problems of high cost of propellants, poor drug atomization effect, and high spray pressure, and achieves improved effective utilization and shortened action time. , Applicable to a wide range of groups

Inactive Publication Date: 2015-06-10
CHINA TOBACCO YUNNAN IND
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  • Abstract
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Problems solved by technology

[0005] The representative patent for pressurized atomization of traditional Chinese medicine compound preparations is CN102949573A, in which an 80-100bar propellant such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane is used to atomize the liquid medicine to To obtain micron-sized mist droplets, the above-mentioned injection pressure is too high, the airtightness of the propellant container tank is strict, the production cost is high, and the propellant itself is also expensive
In addition, with the increase of the amount of medicine used, the pressure inside the tank decreases continuously, and the drug atomization effect gradually becomes worse; moreover, such tanks can only be used once for consumers, increasing usage cost

Method used

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Embodiment 1

[0032] An aerosol precursor comprising medicinal ingredients of Chuanbei loquat syrup, which comprises glycerol, propylene glycol, 1,3-butanediol, flavoring substances and Chuanbei loquat syrup extract, and their mass ratio is glycerol Alcohol: propylene glycol: Chuanbei loquat syrup extract = 40:20:1.

[0033] Wherein said Chuanbei loquat syrup extract is obtained by the method comprising the following steps:

[0034] (1) Impurity removal: Dissolve the Chuanbei loquat syrup in edible grade ethanol, filter, remove insoluble impurities, and obtain the ethanol solution of Chuanbei loquat syrup;

[0035](2) decolouring: the ethanol solution of the Chuanbei loquat syrup obtained in step (1) is passed through the first macroporous resin chromatographic column, and is 40 volume % ethanol-water solution elution with concentration, removes the pigment component wherein; Wherein The model of the first macroporous resin chromatographic column is preferably MCIGEL CHP20P (75-150 μm).

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Abstract

The invention relates to an aerosol precursor containing pharmacodynamic ingredients of Chuanbei Pipa syrup. The aerosol precursor contains glycerol, propanediol, 1,3-butanediol, an aromatic substance and a Chuanbei Pipa syrup extract in a mass ratio of (40-45):(20-25):(0-10):(0-10):(1-10). The invention also relates to a method for dispersing the pharmacodynamic ingredients of Chuanbei Pipa syrup into nano-scale frog drops, and also relates to an aerosol containing the nano-scale frog drops. The aerosol precursor provided by the invention contains the pharmacodynamic ingredients of the Chuanbei Pipa syrup, and the nano-scale frog drops can be obtained by heating the aerosol precursor in an electronic cigarette smoking set comprising an electric heating device, so that the aerosol precursor is more beneficial for a human body to absorb the pharmacodynamic ingredients.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing medicinal components of Chuanbei loquat syrup and a method for dispersing it into nano-scale droplets. Background technique [0002] The main ingredients of Chuanbei loquat syrup are Chuanbeimu liquid extract, bellflower, loquat leaf, and menthol. It is a brownish-red viscous liquid; fragrant, sweet, slightly bitter, and cool, and has the effects of clearing away heat and relieving lungs, reducing phlegm and relieving cough. Usually, the administration method of Chuanbei loquat syrup is oral administration. On the one hand, the drug effect is slow; Drug utilization decreased. [0003] Aerosols generally refer to preparations that produce droplets when heated or pressurized. In the field of medicine and pharmacy, aerosols refer to preparations that contain medicinal liquids, emulsions or suspensions that are sprayed out in the form of mist for lung inhalat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/12A61P11/00A61P11/10A61K31/045
Inventor 韩敬美杨柳赵伟田永峰杨继杨钰婷段沅杏秦云华陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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