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Traditional Chinese medicine formula for preventing and treating immunosenescence and preparation method thereof

An immunosenescence, traditional Chinese medicine technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems that the curative effect can only be improved by improving the immune organ index, the overall role of NK cells and T cells, etc., to achieve prevention and treatment. The effect of T cell immune senescence, clear curative effect and good cell selectivity

Active Publication Date: 2015-06-10
INST OF BASIC MEDICINE OF SAMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are reports of Zuogui Pills and Bushen Recipe as traditional Chinese medicines for regulating cellular immunity, but their curative effects are only reported to improve the immune organ index, NK cells, and T cells as a whole, and there are no reports targeting different T cell subsets to exert cell selectivity and Compatible preparations of traditional Chinese medicine with strong effects

Method used

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  • Traditional Chinese medicine formula for preventing and treating immunosenescence and preparation method thereof
  • Traditional Chinese medicine formula for preventing and treating immunosenescence and preparation method thereof
  • Traditional Chinese medicine formula for preventing and treating immunosenescence and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 6g of rehmannia glutinosa, 5g of dendrobium, 5g of Chinese yam, 5g of medlar, 4g of dogwood, 6g of dodder, 4g of eucommia, 3g of cinnamon, 3g of angelica, 6g of astragalus, 5g of white peony, 5g of Polygonatum odoratum, and 5g of chuanxiong. After rinsing with water, add 10 times the volume 75% ethanol, soak for 2 hours, reflux and decoct for 1.5 hours, filter the medicinal solution, add 10 times the volume of 50% ethanol to the medicinal residue, reflux and decoct for 1.5 hours, filter and collect the medicinal solution, combine the medicinal solutions, concentrate under reduced pressure at 80°C to recover ethanol , to collect the alcohol extract to obtain the ethanol extract. Add 10 times the volume of water to the medicinal dregs, decoct for 1.5 hours, filter the medicinal liquid, concentrate it into a paste, combine ethanol and water extraction and alcohol precipitation extracts, and make ointment, water, granules, syrup, etc., so that the crude drug 1.92g / ml....

Embodiment 2

[0020] Take Rehmannia glutinosa 400, Dendrobium 500, Yam 200, Lycium barbarum 300, Dogwood 400, Dodder 400, Eucommia 400, Cinnamon 100, Angelica 300, Astragalus 600, Paeoniae Alba 500, Polygonatum 500, Ligusticum chuanxiong 300, add 10 times the volume after rinsing with water 75% ethanol, soak for 2 hours, reflux and decoct for 1.5 hours, filter the medicinal solution, add 10 times the volume of 50% ethanol to the medicinal residue, reflux and decoct for 1.5 hours, filter and collect the medicinal solution, combine the medicinal solutions, concentrate under reduced pressure at 80°C to recover ethanol , to collect the alcohol extract to obtain the ethanol extract. Add 10 times the volume of water to the medicinal dregs, decoct for 1.5 hours, filter the medicinal liquid, concentrate it into a paste, combine ethanol and water extraction and alcohol precipitation extracts, and make ointment, water, granules, syrup, etc., so that the crude drug 1.92g / ml.

Embodiment 3

[0022] Take Rehmannia glutinosa 600, Dendrobium 400, Yam 500, Lycium barbarum 400, Cornus officinalis 100, Cuscuta 600, Eucommia 150, Cinnamon 300, Angelica 100, Astragalus 400, Paeoniae Alba 200, Polygonatum 200, Ligusticum chuanxiong 500, add 10 times the volume after rinsing with water 75% ethanol, soak for 2 hours, reflux and decoct for 1.5 hours, filter the medicinal solution, add 10 times the volume of 50% ethanol to the medicinal residue, reflux and decoct for 1.5 hours, filter and collect the medicinal solution, combine the medicinal solutions, concentrate under reduced pressure at 80°C to recover ethanol , to collect the alcohol extract to obtain the ethanol extract. Add 10 times the volume of water to the medicinal dregs, decoct for 1.5 hours, filter the medicinal liquid, concentrate it into a paste, combine ethanol and water extraction and alcohol precipitation extracts, and make ointment, water, granules, syrup, etc., so that the crude drug 1.92g / ml.

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Abstract

The invention provides a traditional Chinese medicine formula for preventing and treating immunosenescence. The traditional Chinese medicine is prepared from the following medicaments in parts by weight: 6-600 parts of prepared rhizome of adhesive rehmannia, 5-500 parts of stems of noble dendrobium, 5-500 parts of Chinese yam, 5-500 parts of wolfberry fruits, 4-400 parts of common macrocarpium fruits, 6-600 parts of Chinese dodder seeds, 4-400 parts of eucommia barks, 3-300 parts of cassia barks, 3-300 parts of Chinese angelica, 6-600 parts of milkvetch roots, 5-500 parts of white paeony roots, 5-500 parts of fragrant solomonseal rhizome and 5-500 parts of szechuan lovage rhizome. Meanwhile, the invention also provides a preparation method of the traditional Chinese medicine formula. The traditional Chinese medicine provided by the invention can promote the activity of Tn and Th1 type subgroups in T cell subgroups in a targeting manner while improving the indexes of lymphoid organs including the spleen, the thymus and the like and the NK and NKT cell activity, and can prevent and treat the immunosenescence of T cells and promote the immunologic reconstitution of the T cells after radiotherapy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compatible preparation for preventing and treating immune aging of T cells and promoting immune reconstruction of T cells and NK cells after radiotherapy, which is a drug combination processed from Chinese medicinal materials. Strong controllability and clear curative effect. It can be used for radiation immune injury, T cell immune reconstruction after tumor radiotherapy, and prevention of major diseases. Background technique [0002] T cells are a large and highly heterogeneous population, accounting for about 60% of the body's immune cells. According to the surface markers, it can be divided into CD4+ and CD8+ T cell subsets. Among them, CD4+ T cells can be divided into naive T cells (Naive T, Tn), memory T cells (Memory T cells, Tm) and Effector T cells (Teff), effector T cells are divided into multiple T cell subsets such as Th1 / Th2 / Treg / Th17 according to different functional effects. CD8...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P37/04
Inventor 姚成芳郭钰琪王丽李霞张洪海郑晓丹
Owner INST OF BASIC MEDICINE OF SAMS
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