Medicated soap with adjuvant therapy effect on eczema and preparation method

An adjuvant therapy and functional technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, skin care preparations, etc., can solve the problems of easy damage by heat, deep water-soluble active ingredient content, low water solubility, etc.

Inactive Publication Date: 2015-06-10
TIANJIN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are some active ingredients with low water solubility in licorice, honeysuckle, wild chrysanthemum and cnidium. For example, the main active ingredients of wild chrysanthemum, volatile oil, flavonoids and lactones, have low water solubility, and the main component of cnidium, osthole, is insoluble In water, traditional water decoction extracts have deep color and low content of water-soluble active ingredients; in addition, some main ingredients in licorice and honeysuckle are sensitive to heat and are easily destroyed by heat.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of medicated soap with auxiliary therapeutic effect on eczema, comprising the steps of:

[0021] (1) 25 parts in parts by mass of licorice, 25 parts of honeysuckle, 25 parts of wild chrysanthemum, and 25 parts of Fructus Cnidii are dried, mixed, pulverized, and subjected to supercritical fluid CO 2 Extract for 5 hours under the conditions of critical temperature Tc=40-45°C and critical pressure Pc=35-40MPa to obtain Chinese medicine extract;

[0022] (2) In parts by mass, heat and melt 65 parts of polyethylene glycol 6000, add 35 parts of the Chinese medicine extract obtained in step (1), mix and stir evenly, let cool, and pulverize to obtain the Chinese medicine extract-solid dispersion body;

[0023] (3) In parts by mass, heat 84 parts of soap base to melt, add 12 parts of Chinese medicine extract-solid dispersion and 4 parts of honey, stir evenly, inject into mold, cool and solidify, form mold, and dry to obtain a A medicated soap with adjuvant...

Embodiment 2

[0025] A preparation method of medicated soap with auxiliary therapeutic effect on eczema, comprising the steps of:

[0026] (1) 30 parts in parts by mass of licorice, 30 parts of honeysuckle, 30 parts of wild chrysanthemum, and 10 parts of Fructus Cnidii are dried, mixed, pulverized, and subjected to supercritical fluid CO 2 Extract for 6 hours under the conditions of critical temperature Tc=40-45°C and critical pressure Pc=35-40MPa to obtain Chinese medicine extract;

[0027] (2) In parts by mass, heat and melt 70 parts of polyethylene glycol 4000, add 30 parts of the Chinese medicine extract obtained in step (1), mix and stir evenly, let cool, and pulverize to obtain the Chinese medicine extract-solid dispersion body;

[0028] (3) In parts by mass, heat 94 parts of soap base to melt, add 4 parts of Chinese medicine extract-solid dispersion and 2 parts of honey, stir evenly, inject into mold, cool and solidify, form mold, and dry to obtain a A medicated soap with adjuvant ...

Embodiment 3

[0030] A preparation method of medicated soap with auxiliary therapeutic effect on eczema, comprising the steps of:

[0031] (1) 26 parts in parts by mass of licorice, 26 parts of honeysuckle, 26 parts of wild chrysanthemum, 22 parts of Fructus Cnidii, dry, mix, pulverize, and pass through supercritical fluid CO 2 extracting for 4 hours under the conditions of critical temperature Tc=40-45°C and critical pressure Pc=35-40MPa to obtain Chinese medicine extract;

[0032] (2) In parts by mass, heat and melt 68 parts of polyethylene glycol 6000, add 32 parts of the Chinese medicine extract obtained in step (1), mix and stir evenly, let cool, and pulverize to obtain the Chinese medicine extract-solid dispersion body;

[0033] (3) In parts by mass, heat 86 parts of soap bases to melt, add 11 parts of Chinese medicine extract-solid dispersion and 3 parts of honey, stir evenly, inject into molds, cool and solidify, form molds, and dry to obtain a A medicated soap with adjuvant thera...

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PUM

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Abstract

The invention discloses a medicated soap with an adjuvant therapy effect on eczema and a preparation method. The preparation method of the medicated soap comprises the following steps: (1) drying, mixing and crushing liquoric root, honeysuckle, wild chrysanthemum and fructus cnidii and performing supercritical fluid CO2 extraction to obtain Chinese medicinal extract; (2) heating and smelting polyethylene glycol 6000 or polyethylene glycol 4000, adding the Chinese medicinal extract obtained in the step (1), uniformly mixing and stirring, cooling, and crushing to prepare Chinese medicinal extract-solid dispersion; (3) heating to melt a soap base, adding the Chinese medicinal extract-solid dispersion and honey, uniformly stirring, performing injection molding, cooling, solidifying, forming, reversing mold and drying to obtain the medicated soap with the adjuvant therapy effect on the eczema. The medicated soap with the adjuvant therapy effect on the eczema has heat clearing, dampness eliminating and itching relieving effects, and has a certain effect on adjuvant therapy on the eczema.

Description

technical field [0001] The invention relates to a medicated soap with auxiliary therapeutic effect on eczema and a preparation method thereof. Background technique [0002] Eczema accounts for about 20% of outpatients in the dermatology department. Chronic eczema is recurrent and difficult to heal, which brings great pain to patients physically and mentally. The location of eczema is on the surface, and the lesion is exposed. By applying topical medicine to the patient, the efficacy of the medicine can reach directly to the disease site and play a local therapeutic role. . At present, the external medicines of western medicine for treating chronic eczema are mainly glucocorticoids, which have anti-inflammatory, antipruritic and anti-proliferative effects, and can be effective in a short time, but patients are prone to dependence on the medicine, and they are prone to recurrent attacks after stopping the medicine, and It may induce local adverse reactions such as skin infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D9/50C11D9/38A61K36/484A61P17/00A61Q19/10A61K35/644
Inventor 刘芳赵威彧邸利芝刘斌赵亮
Owner TIANJIN MEDICAL COLLEGE
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