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Detection method for traditional Chinese medicine preparation compounded Sichuan fritillary bulb extract tablets

A technology of compound Chuanbei essence tablet and detection method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of identification of unephedra root and Bai Wei, etc., and achieve the same extraction effect, good separation degree, and short development time Effect

Active Publication Date: 2015-07-15
九寨沟天然药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing detection methods of Fufang Chuanbeijing Tablets and Capsules, neither Ephedra root nor Baiwei was identified

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0058] Preparation of reference substance solution: Take 10mg of ephedrine hydrochloride reference substance, accurately weigh it, put it in a 100ml measuring flask, add methanol to dilute to the mark, shake well, accurately measure 2ml, place it in a 25ml measuring flask, and dilute to the mark with mobile phase , Shake well to make a reference solution containing 8μg of ephedrine hydrochloride per 1ml.

[0059] Preparation of test solution: Take 20 tablets of this product, grind finely, accurately weigh 0.4~0.6g of this product, put it in a 100ml measuring flask, add 50~70ml methanol, and ultrasonically treat 15~20min at a power of 120W and a frequency of 59KHz. , Dilute with methanol to the mark, shake well, filter, and discard the initial filtrate to obtain the test solution.

[0060] Determination method: accurately draw 8-12μl each of the reference solution and the test solution, and inject it into the liquid chromatograph for determination; each tablet of this product contai...

Embodiment 1

[0069] (1) Qualitative identification by thin layer chromatography

[0070] Qualitative identification of ephedrine and ephedrine A by thin-layer chromatography: Take 10 tablets of this product, grind them into fine pieces, add 30ml of water to dissolve, shake and extract with ether twice, each time the amount of ether is 20ml; discard the ether solution , The water solution is evaporated to dryness in a water bath, the residue is dissolved in 20ml of ethanol, filtered, the filtrate is evaporated to dryness in a water bath, and the residue is dissolved in 1ml of methanol to dissolve, as the test solution; another reference substance of ephedrine root and ephedrine A reference substance, Add methanol to make a mixed solution containing 1mg of ephedrine reference substance and 1mg of ephedrine A reference substance per 1ml, as the reference substance solution; according to TLC "Chinese Pharmacopoeia" 2010 edition a Appendix VIB test, absorb the above supply 10μl each of the test so...

Embodiment 2

[0081] (1) Qualitative identification by thin layer chromatography

[0082] Qualitative identification of ephedrine and ephedrine A by thin-layer chromatography: take 10 tablets of this product, grind them into fine pieces, add 40ml of water to dissolve, shake and extract 3 times with ether, each time the amount of ether is 30ml; discard the ether solution , The water solution is evaporated to dryness in a water bath, the residue is dissolved by adding 30ml of ethanol, filtered, the filtrate is evaporated to dryness in a water bath, and the residue is dissolved by adding 2ml of methanol to dissolve, as the test solution; another reference substance of ephedrine root and ephedrine A reference substance, Add methanol to make a mixed solution containing 1mg of ephedrine reference substance and 1mg of ephedrine A reference substance per 1ml, as the reference substance solution; according to TLC "Chinese Pharmacopoeia" 2010 edition a Appendix VIB test, absorb the above supply 12μl eac...

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Abstract

The invention discloses a detection method for traditional Chinese medicine preparation compounded Sichuan fritillary bulb extract tablets. The detection method comprises the steps of carrying out thin-layer chromatography qualitative identification and carrying out content determination, wherein thin-layer chromatography qualitative identification comprises the steps of identifying ephedrannin and neoephedrine A in the preparation, identifying polygala root and cynanchum atratum and identifying glycyrrhiza uralensis and schisandra fruit; content determination comprises the step of determining the content of ephedrine hydrochloride in the preparation. The detection method disclosed by the invention has the advantages that the mixing of radix ephedrae and cynanchum atratum is effectively controlled, and meanwhile, the composition and content of the compounded Sichuan fritillary bulb extract tablets is effectively controlled, so that the drug can be safer and more effective.

Description

Technical field [0001] The invention relates to a method for detecting drugs, in particular to a method for detecting compound Chuanbeijing tablets of traditional Chinese medicine preparations. Background technique [0002] Fufang Chuanbei Jing Tablets is a variety included in the 19th volume of the Pharmaceutical Standards of the Ministry of Health. The standard number is WS-B-3622-98. The prescriptions are Ephedra, Schisandra (Vinegar), and Chuanbei. Mother, Polygala (Desperate Licorice Roast), Tangerine Peel, French Pinellia, Platycodon, Licorice Extract, are tablets made of pure Chinese medicine. It has the functions of resolving phlegm and relieving cough, promoting lung and relieving asthma. It is a common medicine used clinically to treat acute and chronic bronchitis, bronchiectasis, cough, and phlegm asthma caused by phlegm saliva obstructing the lung and lung failure. However, the original standard only performed microscopic identification of Pinellia ternata, and TLC ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02G01N30/06
Inventor 钟茂团黎黎温国梁杨辉邹波
Owner 九寨沟天然药业股份有限公司
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