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Pharmaceutical composition for improving complications of high-fat and high-sugar diet and application thereof

A high-fat, high-sugar, high-complication technology, applied in the field of medicine and biology, can solve the problems of large side effects, weak drug efficacy, and single effect, and achieve the effects of reducing dosage, reducing side effects, and improving induced diseases

Active Publication Date: 2015-08-19
上海皋鱼医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a pharmaceutical composition for intervening high-fat and high-glucose-induced diseases, so as to solve the weak efficacy of existing drugs in intervening obesity, liver, kidney complications, hyperglycemia, hyperlipidemia and cardiovascular and cerebrovascular diseases , single action, large side effects and other defects

Method used

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  • Pharmaceutical composition for improving complications of high-fat and high-sugar diet and application thereof
  • Pharmaceutical composition for improving complications of high-fat and high-sugar diet and application thereof
  • Pharmaceutical composition for improving complications of high-fat and high-sugar diet and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation of Baicalinin Combined Oral Preparation 1

[0055] Take a piece of acarbose, add it to 5mL of 0.5% CMC-Na aqueous solution, grind and mix it, accurately pipette 0.64mL with a pipette gun, dilute to 20mL, accurately weigh baicalin 28.98mg, add 20mL. .5% CMC-Na aqueous solution, vortex shaker to make a uniform suspension; the final concentration is 5.7mmol / L, and the final concentration of acarbose is 0.25mmol / L.

Embodiment 2

[0057] Preparation of baicalinin combined oral preparation 2

[0058] Take a piece of acarbose, add it to 5mL of 0.5% CMC-Na aqueous solution, grind and mix well, pipette 0.68mL accurately with a pipette gun, dilute to 20mL, accurately weigh baicalin 41.39mg, add 20mL. .5% CMC-Na aqueous solution, vortex shaker to make a uniform suspension; the final concentration is 8.14mmol / L, and the final concentration of acarbose is 0.25mmol / L.

Embodiment 3

[0060] Preparation of baicalinin combined oral agent 3

[0061]Take a piece of acarbose, add it to 5mL of 0.5% CMC-Na aqueous solution, grind and mix it, pipette 0.64mL accurately with a pipette gun, dilute to 20mL, accurately weigh baicalin 165.61mg, add 20mL. .5% CMC-Na aqueous solution, vortex shaker to make a uniform suspension; the final concentration is 32.57mmol / L, and the final concentration of acarbose is 0.25mmol / L.

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Abstract

The invention provides a pharmaceutical composition for improving complications of high-fat and high-sugar diet. The pharmaceutical composition comprises flavonoid and an alpha-glucosidase inhibitor, wherein the flavonoid is at least one selected from the group consisting of monomer baicalein, monomer chrysin, organic salts of the monomers and inorganic salts of the monomers, and the alpha-glucosidase inhibitor is one selected from the group consisting of monomer acarbose, monomer voglibose, monomer migltol, organic salts of the monomers and inorganic salts of the monomers. The composition provided by the invention can effectively reduce the dosage of the alpha-glucosidase inhibitor; desired effects can be obtained by mixing the flavonoid with the alpha-glucosidase inhibitor with a dosage 0.01 to 0.75 time of a normal dosage; the disadvantages of a great dosage and great side-effects in individual usage of the alpha-glucosidase inhibitor are overcome; the disadvantages of unobvious hypoglycemic effect, a great dosage, a long administration period and the like in individual usage of the flavonoid are overcome; and the disadvantages of complex components and difficult quality control of a traditional Chinese medicine compound drug are overcome.

Description

technical field [0001] The invention relates to a pharmaceutical composition for improving the complications of high-fat and high-sugar diet, which belongs to the field of medicine and biology. Background technique [0002] Modern life continues to accelerate, and high-fat and high-sugar diets are flooding people's lives. A high-fat and high-sugar diet will put the body in a sub-healthy high-load state (Metabolism 2008; 57:1071–7). Moreover, this effect is not to induce a single disease, but a comprehensive effect, which makes all the indicators of the human body deviate from the normal value. High fat and high sugar will lead to an increase in free fatty acid levels and blood sugar levels in the blood, resulting in overload of the liver, kidneys and pancreas, and can easily induce a series of diseases such as diabetes, cardiovascular disease, liver disease, kidney disease, etc. For example, a high-fat and high-sugar diet can accumulate fat and induce obesity; a high-fat a...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/352A61K31/7036A61K31/445A61P3/06A61P3/10A61P3/04A61P9/00A61P1/16A61P13/12A61K31/133
Inventor 董悦生孙文龙张博崴桑元斌于晓霞徐亲民修志龙
Owner 上海皋鱼医药科技有限公司
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