30 results about "High sugar diet" patented technology

The invention provides a lactobacillus plantarum improving easily-fat body and offspring weight and application thereof, and is preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC No.14570. The lactobacillus plantarum has excellent acid and bile salt resistance, bile salt hydrolase activity and intestinal colonization ability. Animal experiments and human food experiments show that the lactobacillus plantarum can control weight gain of pregnant women and offsprings caused by a high-fat and high-sugar diet by bile salt hydrolase activity and regulating intestinal flora, at the same time, the lactobacillus plantarum can regulate the intestinal flora, optimize intestinal flora structure, increase number of beneficial bacteria, and improve ratio of bacteroidetes and firmicutes, thereby improving the easily-fat body. The animal experiments and human food experiments show that the lactobacillus plantarum has clear efficacy and high safety, and can reverse the easily-fat body by fundamentally improving the intestinal flora of humans, has a long-lasting non-rebound effect, and has great potential for market development.

The invention provides application of an extract of radix astragali in treating cadmium-induced diabetic nephropathy. High-fat and high-sugar feeding is adopted, and by combing with intraperitoneal injection of cadmium chloride for induction, a mouse model of cadmium-induced diabetic nephropathy is constructed. Experimental studies are carried out on the pathogenesis and characteristics of cadmium-induced diabetic nephropathy and the protective effect of radix astragali from the aspects of oxidative stress level, related protein expression level and the like, and a new approach for treatment of diabetic nephropathy caused by long-term cadmium exposure and high-fat and high-sugar diet is provided.

The invention discloses a construction method of a non-alcoholic fatty liver mouse model. According to the method, construction of a mouse non-alcoholic fatty liver model is induced by cooperation ofhigh-fat and high-sugar diet and circadian rhythm disorder. The method is short in consumed time, high in modeling success rate, low in cost and free of toxic and side effects caused by use of chemical reagents, and is called as a green animal model.

The invention relates to a method for constructing a type II diabetes model by combining high-fat feeding with streptozotocin induction. According to the method, the high-fat and high-sugar diet is given by simulating the morbidity process of human type II diabetes, so that wide insulin resistance of mice is caused, but the blood sugar is not obviously increased. STZ is a powerful alkylating agentand can cause DNA alkylation, the DNA chain is broken, so that glycosylation of poly adenosinediphosphate ribose is activated, NO is released, the content of nicotinamide adenine in cells is rapidlyreduced, pancreatic beta cells are damaged or necrotic, insulin secretion is reduced, at the moment, most mice have abnormal glucose tolerance, and animal hyperglycemia is induced. The method has themain beneficial effects that the diabetes model of the female ICR mouse is successfully established through the research, and the pathological structure and biochemical detection change trend of the mouse are basically consistent with those of type II diabetes of human beings.

The invention provides a pharmaceutical composition for improving complications of high-fat and high-sugar diet. The pharmaceutical composition comprises flavonoid and an alpha-glucosidase inhibitor, wherein the flavonoid is at least one selected from the group consisting of monomer baicalein, monomer chrysin, organic salts of the monomers and inorganic salts of the monomers, and the alpha-glucosidase inhibitor is one selected from the group consisting of monomer acarbose, monomer voglibose, monomer migltol, organic salts of the monomers and inorganic salts of the monomers. The composition provided by the invention can effectively reduce the dosage of the alpha-glucosidase inhibitor; desired effects can be obtained by mixing the flavonoid with the alpha-glucosidase inhibitor with a dosage 0.01 to 0.75 time of a normal dosage; the disadvantages of a great dosage and great side-effects in individual usage of the alpha-glucosidase inhibitor are overcome; the disadvantages of unobvious hypoglycemic effect, a great dosage, a long administration period and the like in individual usage of the flavonoid are overcome; and the disadvantages of complex components and difficult quality control of a traditional Chinese medicine compound drug are overcome.

The invention relates to application of a hibiscus sabdariffa-green tea composition in relieving diet-induced metabolic disorders, and particularly provides an aqueous extract and a composition with the same. The aqueous extract is the aqueous extract of the mixture of hibiscus sabdariffa flower and green tea or is the mixture of a hibiscus sabdariffa aqueous extract and a green tea aqueous extract. It is found that the hibiscus sabdariffa aqueous extract and the green tea aqueous extract can remarkably relieve weight increment of the body and epididymis fat of a mouse induced by high-fat and high-sugar diet, lower blood glucose and blood fat, improve mouse liver fat deposition and increase insulin sensitivity, while has no obvious influence on the food intake and water intake of the mouse. It is also found that the hibiscus sabdariffa-longjing tea composition extracting solution can lower fatty liver by increasing liver fatty acid oxidation and lowering lipid synthesis; in addition, insulin resistance can be lowered in the way of restraining mTORC1 / S6K.

The invention belongs to the technical field of diabetic animal model construction, and particularly relates to a method for constructing a ZDF (Zucker diabetic fatty) rat model for proliferative diabetic retinopathy (PDR). The method for constructing the model with PDR comprises the following steps: carrying out high-fat and high-sugar diet feeding on ZDF rats, and inducing hyperglycemia formation and dyslipidemia to obtain the rat model for PDR. Experiments find that the rat model obtained by the method can be successfully constructed, the obtained model has obviously increased blood sugar, abnormal lipid metabolism, retinal neovascularization indicated by fundus angiography FFA, vitreous opacity, retinal inner layer thinning indicated by OCT, retinal inner layer thinning indicated by pathology, remarkable reduction of ganglion cells and alteration of garland-like loss of the outer nuclear layer, the modeling time is short, and the application prospect is excellent.

High throughput drug screening assay methods and related apparatus are described. Wild-type Drosophila are raised in multi-well microtiter plates on a growth medium having a high level of a sugar such as glucose. The high sugar diet during development induces screenably distinct characteristics in the wild-type Drosophila. Compounds that putatively modify the screenably distinct characteristic are tested by feeding to the Drosophila embryos, and determining whether the compound modifies the screenably distinct characteristic induced by the high sugar growth medium. The assay methods and related articles of composition can also be used to assay toxicity of candidate compounds.

The invention provides a composition used for adjusting blood sugar. The composition comprises an effective dose of monascine or / and ankaflavin. The invention also provides another composition used for adjusting blood sugar, and the composition comprises an effective dose of a monascus fermentation product obtained via inoculation of culture medium with monascus and further fermentation and preparation. It is confirmed by animal experiments that the composition is capable of adjusting hyperglycemia caused by high fat and high sugar diet effectively, and reducing oxidative stress response and inflammation induced by hyperglycemia effectively. The composition can also be used for reducing AST and ALT values in liver and sarcosine value in kidney synchronously besides reducing of blood glucose concentration, and relieving inflammation of liver and kidney.

The invention relates to applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases. The carbazole compound is 3, 6-dibromo-beta-fluorine-N-(3-methoxyphenyl)-9H-carbazole-9-propylanmine (P7C3-A20). It is confirmed through high fat high sugar diet induced hyperlipidemia, obesity, and fatty liver animalmodel experiments that P7C3-A20 is capable reducing blood fat, blood sugar, obesity, and fatty liver lesion obviously; it is confirmed by cardiac muscle cell ischemic anoxic model simulated ischemic myocardial injury that P7C3-A20 is capable of reducing myocardial cell injury caused by ischemia and anoxia. The advantages are that: 1, the carbazole compound is capable of reducing blood fat, blood sugar, obesity, and fatty liver lesion obviously, preventing and treating fatty liver, and avoiding ischemic myocardial injury; and 2, a novel drug research direction is provided for metabolic bone disease and complications of metabolic bone diseases, and the application prospect is promising.

The invention provides an application of CHRNA4 in preparation of drugs for treating nonalcoholicity steathopatitis. It is disclosed by a nonalcoholicity steathopatitis (abbreviated as NASH) mice induced by high-fat and high-sugar diets that the CHRNA4 can be used as a potential therapeutic target of the NASH, and the therapeutic effect of the antagonist lobelin hydrochloride of the CHRNA4 on theNASH is proved to provide a new way to treat the NASH.

The invention relates to new application of borapetoside E in preparing drugs for preventing and treating metabolic diseases of fatty liver, obesity and the like. A research discovers that a compound borapetoside E of which the dosage is40 mg / kg is capable of obviously reducing the level of triglyceride, cholesterol and free fatty acid in livers of HFGD (High Fat and Glucose Diet) induced mice; the obesity symptom of the HFGD induced mice is remarkably relieved, and energy metabolism of the HFGD induced mice is promoted; the action mechanism can be related to SREBP (Sterol Regulatory Element Binding Proteins) inhibition. The curative effect of the compound borapetoside E under the dosage is superior to that of 200mg / kg of metformin, and the compound borapetoside E can be used for preparing the drugs, healthcare products and functional food for preventing and treating the fatty liver and the obesity.

The invention utilizes a high-fat high-sugar diet induced nonalcoholic steatohepatitis (short for NASH) mouse, discloses that farnesyl pyrophosphate synthase (FDPS) can be used as a potential therapeutic target for the NASH, proves a treatment function of the antagonist, i.e., alendronate sodium, of the FDPS for the NASH, and provides a new thought for developing NASH treatment medicines.

The present invention utilizes high-fat and high-sugar diet-induced nonalcoholic steatohepatitis (NASH) mice to reveal that CHRNA4 can be used as a potential therapeutic target for NASH, and confirms the effect of its antagonist lobeline hydrochloride on NASH. Therapeutic effect provides a new way for the treatment of NASH.

The present invention provides a strain of Lactobacillus plantarum for improving fat-prone physique and progeny body weight and its application. It is preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC No.14570. It has excellent acid and bile salt resistance, Bile salt hydrolysis enzyme activity and intestinal colonization ability, animal experiments and human feeding experiments show that the bacteria can control the weight gain of pregnant women and offspring caused by high-fat and high-sugar diet through bile salt hydrolysis enzyme activity and regulation of intestinal flora, and at the same time , the bacterium can regulate the intestinal flora, optimize the structure of the intestinal flora, increase the number of beneficial bacteria, improve the ratio of Bacteroides and Firmicutes, thereby improving obesity-prone physique. Both animal experiments and human food testing experiments have proved that the bacterium has clear efficacy and high safety. It can reverse the fat-prone physique by fundamentally improving the human intestinal flora. The effect is long-lasting and does not rebound, and it has huge market development potential.

The invention discloses a rapid establishment method of a periodontitis model and a treatment medicine. A simple rat periodontitis model is successfully obtained through second molars on the two sides of the maxillary of a rat in cooperation with 5-day high-sugar diet. After the rat periodontitis model is established, neutral pseudo-ginseng polysaccharide is applied to the model, a reference basis is provided for comprehensive utilization of pseudo-ginseng resources, after treatment with the neutral pseudo-ginseng polysaccharide, rat inflammation is relieved, alveolar bone loss is remarkably inhibited, and gingival bleeding is greatly protected; and the new application of the neutral pseudo-ginseng polysaccharide in periodontitis treatment is added, and biological research on treatment of periodontitis by the neutral pseudo-ginseng polysaccharide is provided.

The invention discloses a making method of a healthy meal. The making method comprises the following steps: step 1, selecting raw materials; step 2, cleaning and soaking; step 3, slitting the raw materials; step 4, pretreating the raw materials; step 5, weighing the raw materials; step 6, packaging the raw materials; step 7, manufacturing a material bag; and step 8, product packaging. The special seasoning bag is adopted for making, the content of oil, salt and sugar in meals is greatly reduced, chronic diseases caused by high-salt, high-oil and high-sugar diets are avoided, the amount of food materials is accurately weighed through an electronic scale, it is guaranteed that more than 12 kinds of food materials are matched every day, and more than 25 kinds of food materials are matched every week; meanwhile, the food materials are soaked with baking soda and white vinegar before making, pesticide residues on the food materials are effectively removed, the healthy meal is made through the seasoning bag, meanwhile, the seasoning bag is a water-oil mixture, the boiling point cannot exceed 120 DEG C in the cooking process, no cooking fume is generated, and meanwhile, the nutritional ingredients of the food materials can be reserved.

The invention belongs to the field of health-care products, and particularly relates to a pharmaceutical composition containing gentisic acid and application of the pharmaceutical composition. The composition comprises the effective components of the gentisic acid and cabernet sauvignon pomace extract, wherein the mass percentage of the effective components is 0.3-1.2 wt%, and the balance is a pharmaceutically acceptable carrier; and in the effective components, the mass percent ratio of the gentisic acid to the cabernet sauvignon pomace extract is 1: 5. The application of the pharmaceutical composition containing the gentisic acid and the cabernet sauvignon pomace extract is used for treating obesity and related diseases. According to the obtained pharmaceutical composition, the effectivecomponents of the gentisic acid and the cabernet sauvignon pomace extract can effectively inhibit body obesity caused by high-fat and high-sugar diet and improve glucose tolerance and insulin resistance of the body, so that a new treatment way is opened up for treatment of the obesity and related diseases.

The invention discloses a construction method of a high-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model, and belongs to the field of ophthalmic disease animalmodels. The method disclosed by the invention comprises the following steps of: adding 40% by weight of cane sugar into maintenance feed for blue-violet blue rabbits, and continuously feeding the blue-violet blue rabbits for 24 weeks. According to the method disclosed by the invention, animals can generate age-related macular degeneration symptoms only by diet control; and the method is simple andconvenient and is easy for industrial application.

The present invention relates to the technical field of insect killing, specifically an insect-attracting insect-killing lamp, which includes an insect-attracting lamp tube, an insect baffle, and a trough-shaped container. Insect lamp tube, the insect trap lamp tube, is a compact single-ended fluorescent tube with three light waves of 365nm, 410nm, and 620nm on a lamp cap; the end of the insect trap lamp tube with transparent glass is regarded as a continuous "W "Tubular insect-retaining board with the shape of an insect-retaining board. There is an insect-receiving groove under the insect-repelling board. The amylopectin paste liquid is filled in the insect-receiving groove. Because starch is a high-sugar nutrient feed, and pest corpses are high-protein nutrient feed, it is used to breed fish, chickens, ducks, frogs, toads, snakes, Foxes, etc., not only save the cost of breeding feed, but also deal with the corpses of pests.

The invention discloses a preparation method and application of a compounded Pu'er tea functional composition and belongs to the field of biotechnology and medicines. Effective parts of Pu'er tea, dendrobium nobile and morus plants are subjected to the steps of water extraction, alcohol extraction, alcohol precipitation, organic solvent extraction, concentration, drying and the like to obtain extracts, and the extracts are compounded to obtain a composition capable of improving diseases induced by high-fat and high-sugar diet. The composition disclosed by the invention can be used for improving hyperglycemia, hyperlipidemia and non-alcoholic fatty liver disease induced by the high-fat and high-sugar diet; and compared with single use of the Pu'er tea extract, the effect is obvious, and the application value is obvious. Raw materials in compounded functional food all belong to medicine-food homologous plants, so that the compounded functional food is green and healthy, is low in side effect, good in safety and easy to industrialize and has obvious social benefits and economic values.

The invention discloses a construction method of a high-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model, and belongs to the field of ophthalmic disease animalmodels. The construction method comprises the steps: 10% of lard oil, 35% of sucrose and 0.5% of cholesterol in percentage by weight are added into maintenance feed for chinchilla rabbits, and chinchilla rabbits are continuously fed for 24 weeks. According to the construction method, animals can generate symptoms of dry age-related macular degeneration only by diet control, and the construction method is simple and convenient, and is easy for industrial application.

Autophagy is a universal anti-aging mechanism the chronic induction of which can extend the health span and lifespan of mammals Here the inventors show that triethylenetetramine (TETA), also called trientine, a drug that is approved for the treatment of Wilson disease, can induce autophagy in mouse tissues in vivo. In particular, chronic autophagy stimulation by TETA can improve the metabolic characteristics of mice kept on a high-fat or high-sugar diet without reducing their food uptake, yet attenuating their weight gain. TETA attenuates adioposity, signs of obesity related type-2 diabetes and hepatosteatosis. TETA also mediates hepatoprotective effects against acute ethanol intoxication. Hence, TETA can be considered as a novel autophagy-inducing agent and thus can be used for the treatment of various diseases and in particular for the treatment of obesity, as well as obesity-related comorbidities.

The invention belongs to the technical field of gene engineering, and discloses application of an ASGR1 mutant gene in the preparation of a humanoid low-blood-fat metabolic animal model. Gene editingis performed on the suitable editing sites of an ASGR1 gene sequence, the obtained animal has a significant tolerance effect on a high fat and high sugar diet (the main inducement of atherosclerosis),and can be adopted as a model for the prevention of human atherosclerosis diseases; natural breeding can be performed to establish a stable breeding group, and the large-scale preparation requirementof the gene mutation model can be met. The invention further discloses a method for preparing the humanoid low-blood-fat metabolic animal model on a large scale.

The invention relates to application of a hibiscus sabdariffa-green tea composition in relieving diet-induced metabolic disorders, and particularly provides an aqueous extract and a composition with the same. The aqueous extract is the aqueous extract of the mixture of hibiscus sabdariffa flower and green tea or is the mixture of a hibiscus sabdariffa aqueous extract and a green tea aqueous extract. It is found that the hibiscus sabdariffa aqueous extract and the green tea aqueous extract can remarkably relieve weight increment of the body and epididymis fat of a mouse induced by high-fat and high-sugar diet, lower blood glucose and blood fat, improve mouse liver fat deposition and increase insulin sensitivity, while has no obvious influence on the food intake and water intake of the mouse. It is also found that the hibiscus sabdariffa-longjing tea composition extracting solution can lower fatty liver by increasing liver fatty acid oxidation and lowering lipid synthesis; in addition, insulin resistance can be lowered in the way of restraining mTORC1 / S6K.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fruit polyphenol and probiotic composition as well as a preparation method and application thereof. The invention relates to a fruit polyphenol probiotic beverage, which comprises fruit polyphenol and probiotics, and the mass percentage of the fruit polyphenol to the probiotics is (20.2-11200): 3 according to the mass percentage of the fruit polyphenol to the probiotics. According to the invention, a simple separation process of fruit polyphenol and probiotic functional active components with functions of reducing blood sugar, reducing blood fat and losing weight is optimized based on a high-fat and high-sugar diet obesity model mouse. The fruit polyphenol component and the probiotics with the functions of reducing blood sugar, reducing blood fat and losing weight are optimally combined, so that the composition has very remarkable activity when being used for reducing blood sugar, reducing blood fat and losing weight, and has no side effect.

The invention belongs to the field of healthcare products and particularly relates to a pharmaceutical composition containing p-coumaric acid and application of the composition. The effective components of the composition include p-coumaric acid and chlorogenic acid, wherein the mass percentage of the effective components is 0.1-0.8 wt%, and the other component of the composition is a pharmaceutically acceptable carrier. In the effective components, the mass percentage ratio of p-coumaric acid to chlorogenic acid is (4:1)-(1:4). The pharmaceutical composition containing p-coumaric acid is applied to treatment of obesity and related diseases. According to the obtained pharmaceutical composition, the effective components, namely p-coumaric acid and chlorogenic acid, of the pharmaceutical composition can effectively inhibit organism obesity caused by a high-fat and high-sugar diet and improve the glucose tolerance and insulin resistance of the organism, and therefore a new treatment way is provided for treatment of obesity and related diseases.