30 results about "High sugar diet" patented technology

High throughput drug screening assay methods and related apparatus are described. Wild-type Drosophila are raised in multi-well microtiter plates on a growth medium having a high level of a sugar such as glucose. The high sugar diet during development induces screenably distinct characteristics in the wild-type Drosophila. Compounds that putatively modify the screenably distinct characteristic are tested by feeding to the Drosophila embryos, and determining whether the compound modifies the screenably distinct characteristic induced by the high sugar growth medium. The assay methods and related articles of composition can also be used to assay toxicity of candidate compounds.

The present invention provides a strain of Lactobacillus plantarum for improving fat-prone physique and progeny body weight and its application. It is preserved in the General Microbiology Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC No.14570. It has excellent acid and bile salt resistance, Bile salt hydrolysis enzyme activity and intestinal colonization ability, animal experiments and human feeding experiments show that the bacteria can control the weight gain of pregnant women and offspring caused by high-fat and high-sugar diet through bile salt hydrolysis enzyme activity and regulation of intestinal flora, and at the same time , the bacterium can regulate the intestinal flora, optimize the structure of the intestinal flora, increase the number of beneficial bacteria, improve the ratio of Bacteroides and Firmicutes, thereby improving obesity-prone physique. Both animal experiments and human food testing experiments have proved that the bacterium has clear efficacy and high safety. It can reverse the fat-prone physique by fundamentally improving the human intestinal flora. The effect is long-lasting and does not rebound, and it has huge market development potential.

In this paper, by constructing a mouse model of liver-specific knockout of CREBZF, it was found that liver-specific knockout of CREBZF significantly slowed down the weight gain of mice induced by a high-fat and high-sugar diet, lowered blood sugar and blood lipids, improved liver fat deposition in mice, and increased glucose tolerance. Receptivity, slow down lipid accumulation in liver cells. Therefore, this article relates to the application of CREBZF in the treatment, prevention and diagnosis of metabolic diseases. Specifically, this paper provides the following reagents in the preparation of slowing down the weight gain of the subject, lowering the blood glucose and blood lipids of the subject, improving the fat deposition in the liver of the subject, increasing the glucose tolerance of the subject, and / or slowing down the purposes of the medicine of the object's liver cell lipid accumulation: ( 1) an agent that reduces expression of a CREBZF protein in a subject; and / or (2) an agent that reduces the activity of a CREBZF protein expressed in a subject.

The invention relates to new application of borapetoside E in preparing drugs for preventing and treating metabolic diseases of fatty liver, obesity and the like. A research discovers that a compound borapetoside E of which the dosage is40 mg / kg is capable of obviously reducing the level of triglyceride, cholesterol and free fatty acid in livers of HFGD (High Fat and Glucose Diet) induced mice; the obesity symptom of the HFGD induced mice is remarkably relieved, and energy metabolism of the HFGD induced mice is promoted; the action mechanism can be related to SREBP (Sterol Regulatory Element Binding Proteins) inhibition. The curative effect of the compound borapetoside E under the dosage is superior to that of 200mg / kg of metformin, and the compound borapetoside E can be used for preparing the drugs, healthcare products and functional food for preventing and treating the fatty liver and the obesity.