Temperature-sensitive sol

A technology of sensitive sol and sol, which is applied in aerosol delivery, drug combination, sexual diseases, etc., to achieve the effects of scientific and reliable principle, simple preparation and operation, and broad application prospects.

Active Publication Date: 2015-09-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no patent documents and news reports about the application of chitosan/carboxymethyl chitosan/glycerophosphate system in

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The percentage by weight of each composition in the thermosensitive sol that present embodiment relates to is: chitosan acetic acid solution 15%, carboxymethyl chitosan aqueous solution 15% and beta-glycerophosphate sodium aqueous solution 70%; Said chitosan acetic acid solution The mass percentage concentration of the carboxymethyl chitosan aqueous solution is 4.4%, the mass percentage concentration of the aqueous solution of β-glycerophosphate sodium is 7.8%.

[0016] The temperature-sensitive sol involved in this example is divided into 10ml systems, and stored in a sterile low-temperature environment at 4-15°C for 6-12 months; the temperature-sensitive sol involved has good fluidity at room temperature and has thermal gelation properties At a temperature of 37°C, the temperature-sensitive sol transforms into a gel with poor fluidity within 20s-5min.

[0017] The temperature-sensitive sol involved in this example is used to treat gynecological inflammations such as v...

Embodiment 2

[0019] The percentage by weight of each composition in the thermosensitive sol that present embodiment relates to is: chitosan acetic acid solution 10%, carboxymethyl chitosan aqueous solution 10% and beta-glycerophosphate sodium aqueous solution 80%; Said chitosan acetic acid solution The mass percentage concentration of the carboxymethyl chitosan aqueous solution is 2.2%, the mass percentage concentration of the β-glycerophosphate sodium aqueous solution is 8%.

Embodiment 3

[0021] The percentage by weight of each composition in the thermosensitive sol that present embodiment relates to is: chitosan acetic acid solution 30%, carboxymethyl chitosan aqueous solution 30% and beta-glycerophosphate sodium aqueous solution 40%; Said chitosan acetic acid solution The mass percentage concentration of the carboxymethyl chitosan aqueous solution is 6.7%, the mass percentage concentration of the β-glycerophosphate sodium aqueous solution is 6%.

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Abstract

The invention belongs to the technical field of medical medicine manufacturing and particularly relates to temperature-sensitive sol for treating gynecologic inflammation such as vaginitis. The temperature-sensitive sol comprises a chitosan acetic acid solution, a carboxymethyl chitosan aqueous solution and a sodium beta-glycerophosphate aqueous solution. Chitosan is dissolved into acetic acid and carboxymethyl chitosan and sodium beta-glycerophosphate are respectively dissolved into ultrapure water to obtain the three kinds of solutions, and the three kinds of solutions are evenly mixed according to set process steps to be manufactured into the temperature-sensitive sol. During use, medicine is loaded to allow the temperature-sensitive sol to be mixed with the medicine to form gel, and the gel can continuously release the medicine on the affected part for 5-7 days. The temperature-sensitive sol is scientific and reliable in principle, simple to manufacture and operate, evident in curative effect, capable of overcoming the defect that similar products can only be applied at night, and promising in application prospect.

Description

Technical field: [0001] The invention belongs to the technical field of medical medicine manufacturing, and in particular relates to a temperature-sensitive sol, which is loaded with medicine and mixed into a gel during use, and is used for treating gynecological inflammations such as vaginitis. Background technique: [0002] The temperature-sensitive in-situ gel drug delivery system refers to that after the drug is administered with a liquid, it is stimulated by a temperature change (body temperature 37°C) at the medicinal site, and the liquid drug solidifies to form a gel, thereby controlling the release of the drug. It is widely used in Eye administration, nasal cavity administration and local injection administration, etc. can effectively reduce drug loss, prolong drug action time, and greatly improve drug bioavailability. site adverse reactions; studies have found that chitosan / carboxymethyl chitosan / glycerophosphate system sol has temperature sensitivity and can be use...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K47/24A61P15/02A61P15/00
Inventor 徐文华刘成玉孔晓颖
Owner QINGDAO UNIV
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