Sucrose sulfate copper type compound as well as preparation method and application thereof

A production method and sulfate technology, applied in the field of medicine, can solve the problems of inducing drug-resistant strains, clinical treatment problems, toxic and side effects, etc., and achieve the effects of broad-spectrum antibacterial activity, promoting wound and burn healing, and efficient antibacterial and anti-inflammatory effects.

Inactive Publication Date: 2015-09-09
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term large-scale use of antibiotics and antibacterial drugs will produce systemic toxic and side effects, such as long-term external use of gentamicin, which will cause ototoxicity and nephrotoxicity; Antibacterial drugs are ineffective and will cause new problems for clinical treatment
Sulfonamides are broad-spectrum antimicrobials, but because many common clinical pathogens are resistant to such drugs, they are only used for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms

Method used

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  • Sucrose sulfate copper type compound as well as preparation method and application thereof
  • Sucrose sulfate copper type compound as well as preparation method and application thereof
  • Sucrose sulfate copper type compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Sucrose sulfate copper compound, its structural formula is (I):

[0035]

[0036] Wherein, R represents 1 / 2Cu.

[0037] The preparation method of sucrose sulfate copper compound comprises the following steps:

[0038] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0039]

[0040] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin is eluted, and the eluents are combined to obtain an aqueous solution of sucrose sulfate copper compound.

[0041] In the preparation method of described sucrose sulfate copper compound, described adsorption has Cu 2+ The second ...

Embodiment 2

[0059] Sucrose sulfate copper compound, its structural formula is (I):

[0060]

[0061] Wherein, R represents 1 / 2Cu.

[0062] The preparation method of sucrose sulfate copper compound comprises the following steps:

[0063] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0064]

[0065] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin is eluted, and the eluents are combined to obtain an aqueous solution of sucrose sulfate copper compound.

[0066] In the preparation method of described sucrose sulfate copper compound, described adsorption has Cu 2+ The second ...

Embodiment 3

[0084] Sucrose sulfate copper compound, its structural formula is (I):

[0085]

[0086] Wherein, R represents 1 / 2Cu.

[0087] The preparation method of sucrose sulfate copper compound comprises the following steps:

[0088] Step 1, the aqueous solution of sodium sucrose sulfate and double distilled water are eluted successively through the first strong acid type cation exchange resin, and the eluents are combined to obtain the aqueous solution of sucrose sulfate, and the structural formula (II) of sucrose sulfate is as follows;

[0089]

[0090] Step 2, the aqueous solution of sucrose sulfate obtained in step 1 and the double distilled water are passed successively through adsorption with Cu 2+ The second weak acid type cation exchange resin is eluted, and the eluents are combined to obtain an aqueous solution of sucrose sulfate copper compound.

[0091] In the preparation method of described sucrose sulfate copper compound, described adsorption has Cu 2+ The second ...

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Abstract

The invention discloses a sucrose sulfate copper type compound which is characterized by having a structural formula (I) shown in the specification, wherein R represents 1 / 2Cu or H, and the number of 1 / 2Cu in the sucrose sulfate copper type compound is more than 1. The invention also relates to a preparation method of the compound, a medicinal composition taking the compound as an active ingredient, and an application of the compound and the medicinal composition disclosed by the invention in preparation of medicaments for treating burn wounds and other trauma infections. The compound disclosed by the invention has efficient and broad-spectrum antibacterial activity, and the medicinal composition of the compound has efficient activity for resisting bacteria, diminishing inflammation and promoting healing of the burn wounds.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to copper sucrose sulfate compounds and their production methods and applications. Background technique [0002] Copper ions have a long history as an antibacterial agent. The antibacterial effect of copper is mainly based on the following mechanism. One is to sterilize bacteria through electric field adsorption. Almost all bacterial cell walls and cell membranes are negatively charged, while metal ions are positively charged. Due to the attraction of opposite charges, the activity of bacteria is restricted, the living microenvironment of bacteria is disordered, and their respiration is inhibited, which eventually leads to "contact death" of bacteria; the second is that copper ions in contact with bacteria will penetrate the cell wall and enter the cell, And react with sulfhydryl groups to coagulate proteins, destroy the activity of cell synthesizing enzymes, and cause cells to lo...

Claims

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Application Information

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IPC IPC(8): C07H11/00C07H1/00A61K31/7024A61P17/02A61P31/02
Inventor 黄燕敏崔建国杨雷甘春芳郑嘉桦
Owner GUANGXI TEACHERS EDUCATION UNIV
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