Application of algin oligosaccharide

A technology of algin oligosaccharides and bacteria, which is applied in the application field of algin oligosaccharides to achieve the effect of broad-spectrum antibacterial activity

Inactive Publication Date: 2009-06-03
XUSN GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as a natural antibacterial agent with high antibacterial activity, algin oligosaccharides have not been reported at home and abroad so far.

Method used

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  • Application of algin oligosaccharide

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Experimental program
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Effect test

Embodiment Construction

[0011] The following is a detailed description of the use of alginate oligosaccharides as a natural bacteriostatic agent with high antibacterial activity through the experimental methods and experimental results.

[0012] The screening and effect evaluation methods of the prepared alginate oligosaccharide antibacterial test are as follows:

[0013] Using 2.5% alginate, 2.5% sodium benzoate and normal saline as controls, the antibacterial effect of 2.5% alginate oligosaccharide solution on Bacillus subtilis and other bacteria was studied. After 24 hours or 72 hours of cultivation, observe the inhibitory effect of the sample solution on different bacterial species, and measure the size of the inhibition zone with a vernier caliper. The specific values ​​are as follows:

[0014] Inhibitory effect of algin oligosaccharides on bacteria (diameter of inhibition zone, mm)

[0015] Strains 2.5% oligosaccharides 2.5% alginate 2.5% sodium benzoate Normal saline Bacillus sub...

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Abstract

The invention relates to application of sugar, in particular to the application of algin oligosaccharide. The invention is characterized in that the algin oligosaccharide is used as a bacteriostat of germs or epiphyte. The invention proves that the bacteriostat can effectively inhibit the growing of Gram-negative bacteria or positive bacteria by bacteriostatic experiments, and shows broad spectrum antibiotic activity; the algin oligosaccharide is proved to have an antiinflammatory action and certain abirritation by acute inflammation experiments on animals.

Description

[0001] This application is a divisional application with the application number: 200610069060.4 and the application date: September 21, 2006: the title of the invention is: a preparation method and application of algin oligosaccharides. technical field [0002] The present invention relates to the application of sugars, especially the application of a kind of algin oligosaccharide. Background technique [0003] In recent years, due to the extensive use of antibiotics, the environment has been polluted, bacterial gene mutations have produced drug resistance, and the rate of drug resistance has gradually increased. Almost all bacteria have acquired drug resistance genes, and this problem has become increasingly serious. In addition to the rational use of antibiotics to deal with bacterial drug resistance, the main countermeasure is to develop new drugs and new preparations that are effective against drug-resistant strains. In recent years, the physiological activity of alginat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61P31/04A61P31/10
CPCY02A50/30
Inventor 张淑平胡佩红卞永平李长青
Owner XUSN GROUP
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