Natural pharmaceutical composition capable of preventing and treating alcoholic liver injury and preparation method

A technology of alcoholic liver injury and natural medicine, which is applied in the field of medicine to achieve the effect of promoting scavenging, eliminating excessive free radicals, and hindering the formation of lipid peroxide

Active Publication Date: 2015-09-16
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no ideal drug to effectively prevent and treat the

Method used

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  • Natural pharmaceutical composition capable of preventing and treating alcoholic liver injury and preparation method
  • Natural pharmaceutical composition capable of preventing and treating alcoholic liver injury and preparation method
  • Natural pharmaceutical composition capable of preventing and treating alcoholic liver injury and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0049] Example 1, Preparation of total triterpene acids in loquat leaves

[0050] (1) Loquat leaves 5kg, decocted and extracted 2 times with 10 times the amount of water, filtered for 2 hours each time, and combined the filtrate for use; the medicine residue was refluxed with 6 times the amount of 80% ethanol and extracted twice, 2 hours each time, filtered, Combine the filtrate, add 400 g of medicinal activated carbon, stir, filter, recover ethanol from the filtrate, concentrate, filter, and dry the filter cake to obtain the total triterpene acid of loquat leaves.

Example Embodiment

[0051] Example 2 , Preparation of total flavonoids in loquat leaves

[0052] (2) Concentrate the water extract of loquat leaves to 7500ml, pass it through the pre-treated AB-8 macroporous resin column, first eluate 4 times the column volume with deionized water, discard the eluate, and then wash with 60% ethanol After removing 5 times the column volume, the eluate was collected, ethanol was recovered, and dried to obtain the total flavonoids of loquat leaves.

Example Embodiment

[0053] Example 3 , Preparation of total flavonoids in loquat leaves 5 kg of Snake Snake grape leaves, extracted twice with 8 times the amount of 60% ethanol at reflux, 3 hours each time, filtered, the filtrate recovered ethanol, concentrated to 7500ml, passed through the pre-treated AB-8 macroporous resin column, and used it first Ionized water eluted 5 times the column volume, discarded the eluent, and then eluted 3 times the column volume with 10% ethanol, discarded the eluent, and then eluted 4 times the column volume with 65% ethanol, and collected the eluate. The ethanol is recovered and dried to obtain the total flavonoids of Snaketooth grape.

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Abstract

The invention relates to a natural pharmaceutical composition capable of alcoholism prevention and liver protection. The composition is composed of loquat leaf total triterpenoid acid, loquat leaf total flavonoids, Ampelopsis grossedentata total flavonoids and a stigma maydis extract. The invention also relates to applications in preparing health foods capable of preventing and treating acute and chronic alcoholic liver injuries and health foods or drinks capable of treating non-alcoholic fatty liver diseases by the composition. Components of the composition of the invention generate good collaboration, treatment effects are obvious, raw materials are easy to obtain, the cost is relatively low, and practicability is strong.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition with natural products for preventing and treating alcoholic liver injury and other related diseases. Background technique [0002] Alcoholic liver damage (ALD) is a toxic liver disease caused by long-term excessive drinking, ALD is a Western nation The leading cause of liver cirrhosis in patients. In my country, alcoholic liver disease has gradually increased in recent years, and has become the second largest cause of liver disease after viral hepatitis. [0003] Alcoholic liver disease is a liver disease caused by long-term heavy drinking. It usually manifests as fatty liver at the initial stage, and then can develop into alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. Severe alcoholism can induce extensive liver cell necrosis or even Liver failure. Up to now, there is no ideal medicine to effectively prevent and treat the occurrence an...

Claims

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Application Information

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IPC IPC(8): A61K36/899A23L1/29A23L2/38A23F3/34A23G3/48A61P1/16
Inventor 胡铭南敏伦郝玉芳候宝王连萍赵宝琴赵全成
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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