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Method for pollen fermentation with bacillus coagulans and its fermentation product and application

A technology of Bacillus coagulans and fermentation products, applied in microorganism-based methods, fermentation, biochemical equipment and methods, etc., can solve the problems of high equipment requirements and high condition control requirements, avoid freeze-drying, easy to colonize the intestinal tract, The effect of strong stomach acid resistance

Active Publication Date: 2018-03-09
广东罗特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a method for pollen fermentation with Bacillus coagulans and its fermentation product and application, aiming to solve the problems of high equipment requirements or high condition control requirements in the existing pollen processing technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Inoculate the preserved strains on the slant strain culture medium, and carry out activation culture at 30°C for 48 hours to obtain the slant strains. The slant culture medium (1L) is: peptone 5g, yeast extract 5g, diammonium hydrogen citrate 1g, glucose 10g, Tween-800.5mL, sodium acetate 1g, dipotassium hydrogen phosphate 1g, magnesium sulfate 0.1g, Manganese sulfate 0.1g, agar 15g, distilled water 1000mL, pH 6.

[0043] 2. Wash the slanted bacteria with sterile water to make a bacterial suspension, and adjust its OD600 to 1.0.

[0044]3. The bacterial suspension was transferred to the liquid strain medium at a ratio of 5% (v / v), and cultured at 30° C. and 100 r / min for 12 hours to obtain liquid strains. The liquid culture medium (1L) is: peptone 5g, yeast extract 1g, diammonium hydrogen citrate 1g, glucose 10g, Tween-80 0.5mL, sodium acetate 1g, dipotassium hydrogen phosphate 1g, magnesium sulfate 0.1g , manganese sulfate 0.1g, distilled water 1000mL, pH 6.

[0...

Embodiment 2

[0048] 1. Inoculate the preserved strains on the slant strain culture medium, and carry out activation culture at 37°C for 24 hours to obtain the slant strains. The slant culture medium (1L) is: peptone 10g, yeast extract 10g, diammonium hydrogen citrate 2g, glucose 15g, Tween-801mL, sodium acetate 4g, dipotassium hydrogen phosphate 2g, magnesium sulfate 0.6g, sulfuric acid Manganese 0.5g, agar 17g, distilled water 1000mL, pH 6.

[0049] 2. Wash the slanted bacteria with sterile water to make a bacterial suspension, and adjust its OD600 to 1.0.

[0050] 3. The bacterial suspension was transferred to the liquid strain culture medium at a ratio of 7% (v / v), and cultured at 35° C. and 150 r / min for 24 hours to obtain liquid strains. The liquid culture medium (1L) is: peptone 10g, yeast extract 10g, diammonium hydrogen citrate 2g, glucose 15g, Tween-80 1mL, sodium acetate 4g, dipotassium hydrogen phosphate 2g, magnesium sulfate 0.6g, Manganese sulfate 0.5g, distilled water 1000m...

Embodiment 3

[0054] 1. Inoculate the preserved strains on the slant strain culture medium, and carry out activation culture at 40°C for 12 hours to obtain the slant strains. The slant culture medium (1L) is: peptone 15g, yeast extract 15g, diammonium hydrogen citrate 3g, glucose 30g, Tween-802mL, sodium acetate 9g, dipotassium hydrogen phosphate 3g, magnesium sulfate 1g, manganese sulfate 1g, 20g agar, 1000mL distilled water, pH 7.

[0055] 2. Wash the slanted bacteria with sterile water to make a bacterial suspension, and adjust its OD600 to 1.0.

[0056] 3. The bacterial suspension was transferred to the liquid strain culture medium at a ratio of 10% (v / v), and cultured at 40° C. and 200 r / min for 30 hours to obtain liquid strains. The liquid culture medium (1L) is: peptone 15g, yeast extract 10g, diammonium hydrogen citrate 3g, glucose 30g, Tween-80 2mL, sodium acetate 9g, dipotassium hydrogen phosphate 3g, magnesium sulfate 1g, sulfuric acid Manganese 1g, distilled water 1000mL, pH 7...

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Abstract

The invention discloses a method for fermenting pollen with Bacillus coagulans and its fermented product and application, comprising the following steps: inoculating the preserved strain of Bacillus coagulans on a slant culture medium, and performing activation culture; using sterile water to inoculate the slant The strains were washed to prepare a bacterial suspension; the bacterial suspension was transferred to a liquid strain culture medium to cultivate and prepare liquid strains; the liquid strains were transferred to pollen for sealed fermentation; trehalose was used as a protective agent for The fermentation product was spray dried. By adopting the method of the invention, the solubility, taste and flavor of the pollen can be significantly improved, and the fermented product can be spray-dried, avoiding high-cost freeze-drying.

Description

technical field [0001] The invention relates to the technical field of microbial fermentation, in particular to a method for pollen fermentation by using bacillus coagulans and its fermentation product and application. Background technique [0002] Bacillus coagulans (Bacillus coagulans) is a rising star in the field of probiotics. It belongs to intestinal lactic acid bacteria, also known as "spore-forming lactic acid bacteria". Not only has the health benefits of lactic acid bacteria and bifidobacteria, but also has strong stress resistance such as high temperature resistance, acid resistance, and choline resistance, and has a strong inhibitory effect on intestinal pathogenic bacteria. After oral administration, it colonizes the blind, colon and rectum, and ferments to produce a large amount of antibacterial coagulogens, lactic acid, amino acids, vitamins and various digestive enzymes. Studies have shown that Bacillus coagulans has a strong tolerance to the acidic conditio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P1/04C12N1/20A23L7/157C12R1/07
CPCC12N1/20C12N1/205C12R2001/07
Inventor 罗楚波杨善岩
Owner 广东罗特制药有限公司