New application of human urine kininogenase and medicine composition comprising same

A technology of urokininogenase and composition, which is applied in the field of medicine, can solve the problems of insignificant therapeutic effect and side effects, and achieve the effects of shortening the latency period of avoiding darkness, restoring memory ability, and alleviating pain

Active Publication Date: 2015-09-30
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drugs have shown certain curative effects in clinical application, there are serious and unavoidable side effects during long-term use, and the therapeutic effect is not significant

Method used

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  • New application of human urine kininogenase and medicine composition comprising same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 3 mg of human urinary kininogenase that was sterilized by filtration, add an appropriate amount of water for injection to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, filter aseptically, and pack into 1000 ampoules In, that is.

[0026] Embodiment 2, the injection of human urinary kallikrein and ginkgolide pharmaceutical composition

Embodiment 2

[0027] Take 2 mg of human urinary kininogenase sterilized by filtration, add appropriate amount of water for injection to dissolve, then add 0.2 mg of ginkgolide to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, Sterile filtration, subpackage into 1000 ampoules, that is to say.

[0028] Embodiment 3, the injection of human urinary kallikrein and ginkgolide pharmaceutical composition

Embodiment 3

[0029] Take 3 mg of human urinary kininogenase sterilized by filtration, add appropriate amount of water for injection to dissolve, then add 1.2 mg of ginkgolide to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, Sterile filtration, subpackage into 1000 ampoules, that is to say.

[0030] Embodiment 4, the injection of human urinary kallikrein and ginkgolide pharmaceutical composition

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Abstract

The invention belongs to the field of medicine, and particularly relates to a new application of human urine kininogenase and a medicine composition comprising the human urine kininogenase. The human urine kininogenase is applied to prepare medicine for treating the Alzheimer's disease. The invention further provides the medicine composition for treating the Alzheimer's disease. The medicine composition comprises the human urine kininogenase and bilobalide, and further comprises pentoxifyline. The medicine composition can remarkably recover the memory capacity of a patient suffering with the Alzheimer's disease, improve the cognition capacity of the patient suffering with the Alzheimer's disease, delay the disease progress of the Alzheimer's disease, greatly improve the life quality of the patient suffering with the Alzheimer's disease, improve the treatment compliance of the Alzheimer's disease, improve the treatment effect, provide the effective treatment medicine for the patient suffering with the Alzheimer's disease, and greatly relieve pain of the patient of the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of human urinary kallikrein and a pharmaceutical composition containing human urinary kallikrein. Background technique [0002] Human Urinary Kallidinogenase is a serine protease composed of 238 amino acids extracted from human urine. Its main function in the body is to hydrolyze kininogen into kinin, thereby exercising a series of Physiological function, it has the effects of dilating capillaries, relaxing vascular smooth muscle, improving microcirculation, increasing blood flow, anticoagulation, thrombolysis, reducing blood viscosity and lowering blood pressure, etc. It is a protease with high medicinal value. [0003] In recent years, with the in-depth research on human urokininogenase, more and more new uses of human urokininogenase have been found. For example, Chinese patent 101134106B discloses a pharmaceutical composition containing human urokininoge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/49A61K9/08A61P25/28A61K31/365A61K31/522
Inventor 王旭郑少亮许文勤肖益热
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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