4 results about "Pentoxyfylline" patented technology

The present invention relates to an injection composition for lipolysis, which is safe and effective, and more specifically, to an injection composition for lipolysis, which comprises: one or more compounds selected from the group consisting of hyaluronidase and pentoxifylline, and one or more compounds selected from the group consisting of hyaluronidase, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline, pentoxifylline and pentoxifylline. 5 to 10% (v / v) of carnitine (Carnitine); and lidocaine (Lidocaine); and normal saline. As a composition having both safety and efficacy, the injection composition for lipolysis of the present invention has an excellent lipolysis effect, does not cause a yo-yo phenomenon over time, and thus has a characteristic of not causing side effects such as skin depression.

The invention relates to the technical field of crystallization control of chemical bulk drug intermediates, and particularly provides a crystallization method of a pentoxifylline intermediate, which comprises the following steps: adding an acetic acid solution into a 3, 7-dimethylxanthine neutralization reaction solution at 80-85 DEG C until crystals are separated out, carrying out heat preservation and stirring for a first preset time, filtering, washing, and drying to obtain the pentoxifylline intermediate. And continuously adding an acetic acid solution to adjust the pH value of the system to be neutral, carrying out heat preservation stirring for a second preset time, slowly cooling to 45-55 DEG C, carrying out heat preservation stirring for a third preset time, and carrying out solid-liquid separation to obtain the pentoxifylline intermediate. According to the crystallization method provided by the invention, the problems of difficulty in centrifugal separation, easiness in blockage of filter cloth and redness of a wet product caused by high viscosity of a solid-liquid mixture in an existing staged cooling and crystal growing process are solved, the yield of the prepared 3, 7-dimethylxanthine product reaches 65% or above, the purity can reach 99.9% or above, the production efficiency is improved, and the crystallization method is suitable for large-scale industrial production.

The present disclosure relates to an injection composition for lipolysis with both safety and efficacy, and more particularly, to an injection composition for lipolysis including at least one compound hyaluronidase and pentoxifylline; 5 to 10% (v / v) carnitine; lidocaine; and a physiological saline. The injection composition for lipolysis according to the present disclosure is a composition with both safety and efficacy, which is characterized by having an excellent lipolysis effect, and having not only no yo-yo effect over time, but also no side effects such as sagging skin.

The invention provides a pharmaceutical composition for improving neurological symptoms of cerebral apoplexy patients and a preparation method thereof, active ingredients comprise pentoxifylline, honokiol and borneol, and in the pharmaceutical composition, the weight ratio of pentoxifylline to honokiol to borneol is (10-15): (4-6): (6-10); the preferable weight ratio is (11-13): (4-6): (6-8); the most preferable weight ratio is 12: 5: 7, and the effect of the composition is obviously superior to that of pentoxifylline or honokiol or natural borneol or a combination of the pentoxifylline or honokiol or natural borneol with the same dosage.