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Prepn. for stopping vomitus contg. compound pentoxifylline

A technology of pentoxifylline and metoclopramide, which is applied in the fields of metabolic diseases, cardiovascular system diseases, respiratory system diseases, etc., can solve problems such as restriction and frequent occurrence of gastrointestinal reactions, achieve convenient application, reduce adverse reactions, The effect of increasing the curative effect

Inactive Publication Date: 2004-07-21
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But after taking pentoxifylline, the main untoward reactions are nausea, dizziness, anorexia, abdominal distension, vomiting etc., and its incidence rate is all more than 5%, reaches about 30% at most, brings certain misery to the patient, also makes The application of the drug is limited by
In order to understand the occurrence of the above-mentioned side effects, pentoxifylline sustained-release preparations and controlled-release preparations have been launched successively. Although the fluctuation of blood drug concentration has been reduced and the side effects have been partially slowed down, gastrointestinal reactions still occur frequently.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Compound Tablets of Pentoxifylline and Metoclopramide

[0027] prescription:

[0028] Pentoxifylline 100g

[0029] Metoclopramide 20g

[0030] Lactose 100g

[0031] Sodium carboxymethyl starch 50g

[0032] Appropriate amount of talcum powder

[0033] Magnesium Stearate Appropriate amount

[0034] 75% ethanol appropriate amount

[0035] Preparation Process:

[0036] Weigh the above-mentioned pentoxifylline, metoclopramide, lactose, and sodium carboxymethyl starch according to the prescription amount, mix well, add 50ml of 75% ethanol, pass through a 18-mesh sieve to granulate, dry, add an appropriate amount of 20g magnesium stearate , 20g talcum powder, compressed into tablets, made into 1000 pieces.

Embodiment 2

[0038] Preparation of Pentoxifylline and Metoclopramide Compound Injection

[0039] prescription:

[0040] Pentoxifylline 100g

[0041] Metoclopramide 20g

[0042] Water for injection 10L

[0043] Process:

[0044] Get prescription quantity pentoxifylline 100g, metoclopramide 20g, add 10000ml water for injection, fully mix, filter, fill (every 10ml), sterilize, obtain the compound injection of the present invention.

Embodiment 3

[0046] Preparation of Compound Capsules of Pentoxifylline and Metoclopramide

[0047] prescription:

[0048] Pentoxifylline 100g

[0049] Metoclopramide 20g

[0050] Lactose 100g

[0051] Sodium carboxymethyl starch 50g

[0052] Magnesium Stearate Appropriate amount

[0053] 75% ethanol appropriate amount

[0054] Preparation Process:

[0055] Weigh the above-mentioned pentoxifylline, metoclopramide, lactose, and sodium carboxymethyl starch according to the prescription quantity, mix evenly, add a certain amount of 75% ethanol, pass through a 18-mesh sieve to granulate, dry, add 20g of magnesium stearate Mix well and fill into 1000 capsules.

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PUM

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Abstract

A compound trental-sinemet medicine is prepared from sinemet or physiologically receptable salt and trental. Its medical usage is also disclosed.

Description

Technical field: [0001] The invention relates to a compound pharmaceutical preparation, which contains an antiemetic or a physiologically acceptable salt thereof and pentoxifylline as active ingredients, especially metoclopramide or a physiologically acceptable salt thereof and pentoxifylline A compound preparation composed of ketoifylline and the application of the compound preparation in medical treatment. Background technique: [0002] Pentoxifylline, a derivative of theobromine, is a good peripheral vasodilator, especially capable of improving blood circulation in the brain and extremities. It has been found in clinical treatment and pharmacological research that pentoxifylline has a variety of pharmacological properties. Activity, he can increase the elasticity of red blood cells, inhibit platelet aggregation, reduce the concentration of plasma fibrinogen and blood viscosity, thereby reducing the formation of microemboli, so it has significant blood rheological activity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61P3/10A61P9/10A61P9/14A61P11/00A61P13/12
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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