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Cineraria repanda capsule and preparation method thereof

A technology of Senecio and capsules, which is applied in the field of medicine, can solve the problems of low extraction rate of total flavonoids and insignificant antibacterial effect, and achieve the effect of strong antibacterial effect and high extraction rate

Active Publication Date: 2015-11-04
江西亿博医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After carrying out a large amount of research, the present inventor regrettably found that the extraction rate of total flavonoids in the Senecio extract obtained by the extraction method of the prior art is low, and the antibacterial effect is not significant

Method used

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  • Cineraria repanda capsule and preparation method thereof
  • Cineraria repanda capsule and preparation method thereof
  • Cineraria repanda capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, the preparation of Senecio capsules

[0039] 1) Take 240g of Senecio, grind it into fine powder, sieve it, and set aside;

[0040] 2) Another 880g of Senecio was taken, decocted with water, the obtained decoction was filtered, concentrated, and dried under reduced pressure to obtain dry cream I;

[0041] 3) Take 880g of Senecio, add ethanol to reflux for extraction, filter, recover ethanol from the filtrate, dry under reduced pressure to obtain dry cream II;

[0042] 4) Combine the dry paste I and dry paste II, add ethanol, and carry out ultrasonic circulation extraction. The extract is filtered and concentrated into a thick paste to obtain the Senecio extract; add the Senecio extract to the obtained Senecio extract in step 1) for later use The fine powder is made into granules, dried, granulated, packed into capsules, and made into 1000 granules.

Embodiment 2

[0043] Embodiment 2, the preparation of Senecio capsules

[0044] 1) Take 240g of Senecio, grind it into fine powder, sieve it, and set aside;

[0045] 2) Take another 880g of Senecio, add 4 times the amount of water and decoct twice for 2 hours each time, filter, combine the decoction, concentrate, and dry under reduced pressure to obtain dry cream I;

[0046] 3) Take another 880g of Senecio, add 85% ethanol to reflux and extract 3 times, each time for 2 hours, filter, combine the filtrates, recover ethanol, and dry under reduced pressure to obtain dry cream II;

[0047] 4) Combine dry cream I and dry cream II, add 60% ethanol according to the ratio of ethanol (ml) to the sum of the mass of dry cream I and dry cream II (g) is 8:1, and apply ultrasonic waves after adding Ultrasonic cycle extraction, ultrasonic power 120W, the whole ultrasonic cycle extraction time is 22min, each ultrasonic extraction time is 3s, and the intermittent time is 0.5s; the extract is filtered and con...

Embodiment 3

[0048] Embodiment 3, the preparation of Senecio capsules

[0049] 1) Take 240g of Senecio, grind it into fine powder, sieve it, and set aside;

[0050] 2) Take another 880g of Senecio, add 4 times the amount of water and decoct twice for 2 hours each time, filter, combine the decoction, concentrate, and dry under reduced pressure to obtain dry paste I;

[0051] 3) Take another 880g of Senecio, add 85% ethanol to reflux and extract 3 times, each time for 2 hours, filter, combine the filtrates, recover ethanol, and dry under reduced pressure to obtain dry paste II;

[0052] 4) Combine dry cream I and dry cream II, add 60% ethanol according to the ratio of ethanol (ml) to the sum of the mass of dry cream I and dry cream II (g) is 16:1, and apply ultrasonic waves after adding Ultrasonic cycle extraction, ultrasonic power 150W, the whole ultrasonic cycle extraction time is 12min, each ultrasonic extraction time is 3s, and the intermittent time is 0.5s; the extract is filtered and ...

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Abstract

The present invention belongs to the medical technical field, and particularly relates to a cineraria repanda capsule and a preparation method thereof, the cineraria repanda capsule includes a cineraria repanda extract, the cineraria repanda extract is prepared by the following methods: 1) cineraria repanda is taken, and added with water for boiling, and a dry paste I is obtained by filtering, concentrating and drying under reduced pressure of the decoction solution; 2) cineraria repanda with the same weight of the cineraria repanda in the step 1) is taken, added with ethanol for reflux for tow times, and filtered, the filtrates are combined, the ethanol is recovered, and a dry paste II is obtained by drying under reduced pressure; and 3) the dry paste I and the dry paste II are merged, ethanol is added for ultrasonic cycle extraction, and the extraction solution is filtered and concentrated into a thick paste, namely the cineraria repanda extract. Through the method, the cineraria repanda is divided into two parts, one part of the cineraria repanda is added with the water for boiling, the other part of the cineraria repanda is added with the ethanol for reflux for extraction, dry pastes are obtained respectively, and then merged, the ethanol is added for ultrasonic cycle extraction, the extraction rate of total flavonoids in the cineraria repanda extract is greatly improved, and the bacteriostasis effect is significantly better than that of the prior art.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Senecio capsule and a preparation method thereof. Background technique [0002] Senecio scandens Buch.-Ham. is a perennial climbing herb of the Asteraceae Senecio genus, also known as Jiuliming, Yisaoguang, Qianliji, etc. The whole herb is used as medicine, which has the effects of clearing heat and detoxifying, clearing liver and improving eyesight, removing putrefaction and promoting muscle growth, killing insects and relieving itching, and can cure rheumatism, bone pain, dermatitis, eczema, diarrhea, boils and sore throat. Senecio is distributed in 22 provinces and autonomous regions across the country. In Guangdong Province, Senecio is distributed in 18 prefecture-level cities, most notably in western Guangdong. [0003] Senecio has a broad-spectrum antibiotic effect, and has a strong inhibitory effect on Staphylococcus aureus, typhoid bacillus, paratyphoid b...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/48A61P31/04
Inventor 张嵩张对良徐卫国
Owner 江西亿博医药科技发展有限公司
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