Method for determining hardness of blank slice for dry granulation

A technology of dry granulation and embryo flakes, applied in the direction of testing the hardness of materials, etc., can solve the problems that have not yet been seen in data-based characterization of the hardness of dry granulated embryo flakes, the hardness of embryo flakes cannot be objectively quantified, and the accuracy and accuracy are poor. Achieve significant application value, real-time sampling, and high sensitivity

Inactive Publication Date: 2015-11-04
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in research and production, sensory evaluation is generally used to evaluate the hardness of dry granulated embryo flakes, which is highly subjective, poor in precision and accuracy, and cannot objectively quantify the hardness of embryo flakes. Therefore, there is an urgent need for a method that can quickly and accurately measure embryo flakes. Hardness, and at the same time, a method that can realize quantitative evaluation
However, so far, there has been no digital characterization of the hardness of the dry-granulated embryo flakes, nor has there been any relevant report on its measurement method

Method used

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  • Method for determining hardness of blank slice for dry granulation
  • Method for determining hardness of blank slice for dry granulation
  • Method for determining hardness of blank slice for dry granulation

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0031] Example 1: Determination of hardness of kudzu root granules and its application in production process control

[0032] The traditional Chinese medicine Pueraria lobata has the functions of relieving the exterior, reducing fever, promoting body fluids, quenching thirst, and relieving diarrhea, and can improve symptoms such as dizziness and headache in patients with hypertension and diabetes.

[0033] Experience shows that when Pueraria granules are prepared by dry granulation technology, when the hardness of the embryo slices is 25.0kg-29.0kg, the granules have a higher yield and better solubility. Therefore, during the production process, the hardness of the embryo slices should be controlled. Within the range of 25.0kg to 29.0kg.

[0034] 1) Preparation of pueraria granules:

[0035] The prescription of the kudzu root granule decoction pieces is as follows: in 100 parts by weight, the kudzu root extract powder is 85% (by weight), anhydrous lactose is 14% (by weight), ...

Embodiment 2

[0052] Example 2: Determination of hardness of Chuanxiong granule embryo sheet and its application in process screening

[0053] The traditional Chinese medicine Chuanxiong is often used to promote blood and Qi, dispel wind and relieve pain. In the process of screening the optimal dry granulation process parameters for preparing Chuanxiong granules by dry granulation, since the hardness of the embryo flakes of dry granulation has a decisive effect on the quality and yield of the granules, the hardness of the embryo flakes was used as an index to continuously Adjusting the process parameters during dry granulation can conveniently and effectively screen out the best dry granulation process parameters for preparing Chuanxiong granules.

[0054] 1) Preparation of chuanxiong granule embryo slices:

[0055] The prescription of the Chuanxiong granule is: in 100 parts by weight, the extract powder of Chuanxiong is 99.5% (part by weight), and the magnesium stearate is 0.5% (part by wei...

Embodiment 3

[0072] Example 3: Determination of the hardness of Ophiopogon japonicus polysaccharide granule embryo slices and its application in prescription screening

[0073] The traditional Chinese medicine Ophiopogon japonicus has the effect of nourishing yin and clearing away heat, treating internal heat due to yin deficiency or febrile disease, injuring body fluid, upset and thirsty. Research results in recent years have shown that Ophiopogon japonicus polysaccharide has the effect of lowering blood fat and blood sugar, and has a good prospect for the development of health food .

[0074] Since the hardness of the embryo flakes of dry granulation has a decisive effect on the quality and yield of granules, when the process parameters of dry granulation are determined, the product composition and ratio become the main factors determining the hardness of the embryo flakes. Therefore, through the small sample test, with the hardness of the embryo slices as the index, and constantly adjus...

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Abstract

The invention discloses a method for determining the hardness of a blank slice for dry granulation. The method comprises the following steps: setting the following determination parameters of a physical determinator: test pattern, speed before test, test speed, speed after test, deformation quantity, trigger mode, trigger force and data acquisition rate; starting the physical determinator to determine the stress change during deformation of the blank slice for dry granulation and drawing a stress-compression time chart according to the stress change; obtaining the hardness value of the tested blank slice according to the peak stress displayed in the chart. The method has the advantages of simplicity in operation, quickness and accuracy in testing, high sensitivity, strong operability, and the like, fills in a gap in determination of the hardness of the blank slice for dry granulation, provides a technical support for objective judgement of the quality condition of the blank slice for dry granulation and realization of online control of the quality of an intermediate, and also provides a data-based evaluation basis for reasonably screening the dry granulation prescription and the process control parameters.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparation analysis, in particular to a method for measuring the hardness of dry granulated embryo slices. Background technique [0002] Dry granulation technology is widely used and can be used in pharmaceutical, chemical, food and other industries. The production process has many advantages, and it has obvious advantages in terms of output, quality, economic benefits and equipment investment. The key of dry granulation is to compress the raw materials of the preparation into embryo flakes with a certain shape and size, generally 2.5 cm wide and 0.1 cm thick, with a hard texture. For dry granulation, embryo flakes are the first intermediate product in the process, and the quality of embryo flakes is directly related to the quality and yield of granules. There are many indicators to characterize the quality of embryo slices, among which, the hardness of embryo slices is one of the important indicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N3/40
Inventor 杜若飞冯怡曹韩韩阮克锋
Owner SHANGHAI UNIV OF T C M
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