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Drug for treating parkinson disease

A technology for Parkinson's disease and medicine, which is applied in the field of traditional Chinese medicine compositions made of traditional Chinese medicinal materials, can solve the problems of elimination, many medicinal flavors, large compound prescriptions, etc. Effect

Active Publication Date: 2015-11-11
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Chinese patent medicines for the prevention and treatment of Parkinson's disease generally have large compound prescriptions, many medicinal flavors, complex active ingredients, unstable production process, difficult quality control, difficult to guarantee curative effect and other defects, difficult to develop in the market, and will even be gradually eliminated by the market

Method used

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  • Drug for treating parkinson disease
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  • Drug for treating parkinson disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0191] Embodiment 1 (granule):

[0192] Weigh 9kg of red ginseng, 12kg of Radix Polygoni Multiflori, 9kg of Ginkgo biloba leaves and 9kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep boiling slightly for 1.5 hours after the second boiling, Keep simmering for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to 10kg in the obtained dry paste fine powder, add 75% alcohol again to make granules, then dry, granulate, and pack into 10g / bag (every containing medicine dry powder about 3.3g).

Embodiment 2

[0193] Embodiment 2 (granule)

[0194] Weigh 7.800kg of red ginseng, 13.016kg of Radix Polygoni Multiflori, 9.379kg of ginkgo leaves and 8.805kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep slightly boiling after the second boiling. Boil for 1.5 hours, keep boiling slightly for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to 10kg in the obtained dry paste fine powder, add 75% alcohol again to make granules, then dry, granulate, and pack into 10g / bag (every containing medicine dry powder about 3.3g).

Embodiment 3

[0195] Embodiment 3 (granule)

[0196] Weigh 10.140kg of red ginseng, 11.505kg of Radix Polygoni Multiflori, 8.385kg of ginkgo biloba leaves and 8.970kg of Radix Ophiopogon japonicus, add 10 times the amount of water to decoct 3 times, keep boiling slightly for 2.0 hours after the first boiling, and keep slightly boiling after the second boiling. Boil for 1.5 hours, keep boiling slightly for 1.0 hour after the third boil. Then combine the decoctions, filter and concentrate the filtrate under reduced pressure at 80°C to a clear paste with a relative density of 1.25, put it in a decompression drying oven at 60°C to dry the paste, and grind it into fine powder. Add appropriate amount of dextrin and starch to 10kg in the obtained dry paste fine powder, add 75% alcohol again to make granules, then dry, granulate, and pack into 10g / bag (every containing medicine dry powder about 3.3g).

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Abstract

The invention discloses a drug for treating parkinson disease. The drug comprises effective ingredients and a medically acceptable excipient. The drug comprises effective ingredients comprising 20-26wt% of ginseng, 28-34wt% of prepared fleece flower root, 20-26wt% of ginkgo leaf and 20-26wt% of radix ophiopogonis. The drug is an oral preparation in a form of capsules, particles, condensed pills or tablets. A clinical use proves that the drug has the advantages of fast symptom improvement and short treatment course. The drug is prepared from less types of raw materials, can be prepared by simple and easy processes and has a wide application value.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition prepared from raw materials of Chinese medicinal materials. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the central nervous system in middle-aged and elderly people. The main pathological changes are the progressive degeneration and loss of striatal dopamine (DA) neurons in the substantia nigra compacta of the midbrain, and the loss of dopamine content in the striatum. Central nervous system degenerative disease with abnormal gait as the main symptom, unable to take care of oneself, has the characteristics of long disease course and low cure rate, which seriously affects the quality of life of patients; the prevalence rate of people over 65 years old can reach more than 1.7% , and there is an increasing trend year by year. At present, the number of PD patients in my country has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P25/16
Inventor 贝伟剑郭姣
Owner GUANGDONG PHARMA UNIV
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