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A breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption and its preparation method

A wet dressing and transdermal technology, which is used in absorbent pads, medical science, bandages, etc., can solve the problems of long healing period, low moisture permeability, and wound adhesion, and achieves the promotion of transdermal absorption, wound healing, Guaranteed breathability

Active Publication Date: 2018-10-09
扬州市旅游日用品制造总厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preparation of chitosan into dressings for treating wounds, there are many studies in this area, but chitosan dressings currently on the market are prone to adhesion with wounds, low moisture permeability, long healing period, tissue hyperplasia, Unsatisfactory hemostatic effect and other adverse conditions lead to long postoperative nursing cycle and many nursing steps

Method used

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  • A breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption and its preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0016] A breathable and moisturizing dressing with antibacterial and promoting drug transdermal absorption, the composition comprises the following raw materials in parts by weight: N-trimethyl chitosan 12, menthol 8, isopropyl myristate 5, chitosan Sugar 20, loofah fiber 35, isomaltooligosaccharide 8, polyvinyl alcohol 5, sodium hydroxymethyl cellulose 6, glycerin 10, mannitol 8, medicinal powder 12, weakly acidic calcium chloride 3, appropriate amount of deionized water.

[0017] A preparation method of a breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption, comprising the following steps:

[0018] (1) Take the loofah fiber and 10 times of deionized water and mix it, and stir it for 10 hours at a speed of 250 r / min in a constant temperature water bath at 75° C., then filter it with 16 layers of gauze to obtain the loofah fiber extract for subsequent use;

[0019] (2) Mix chitosan and acidic calcium chloride, add 4 time...

Embodiment 2

[0023] A breathable and moisturizing dressing with antibacterial and promoting drug transdermal absorption, the composition comprises the following raw materials in parts by weight: N-trimethyl chitosan 13, menthol 10, isopropyl myristate 6, chitosan Sugar 25, loofah fiber 30, isomaltooligosaccharide 11, polyvinyl alcohol 7, sodium hydroxymethyl cellulose 8, glycerin 11, mannitol 9, medicinal powder 16, weakly acidic calcium chloride 5, appropriate amount of deionized water.

[0024] A preparation method of a breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption, comprising the following steps:

[0025] (1) Take the loofah fiber and 10 times of deionized water and mix it, and stir it for 10 hours at a speed of 250 r / min in a constant temperature water bath at 75° C., then filter it with 16 layers of gauze to obtain the loofah fiber extract for subsequent use;

[0026] (2) Mix chitosan and acidic calcium chloride, add 4 ti...

Embodiment 3

[0030] A breathable and moisturizing dressing with antibacterial and promoting drug transdermal absorption, the composition comprises the following raw materials in parts by weight: N-trimethyl chitosan 14, menthol 12, isopropyl myristate 7, chitosan Sugar 30, loofah fiber 25, isomaltooligosaccharide 14, polyvinyl alcohol 9, sodium hydroxymethyl cellulose 10, glycerin 12, mannitol 10, medicinal powder 20, weakly acidic calcium chloride 7, appropriate amount of deionized water.

[0031] A preparation method of a breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption, comprising the following steps:

[0032] (1) Take the loofah fiber and 10 times of deionized water and mix it, and stir it for 10 hours at a speed of 250 r / min in a constant temperature water bath at 75° C., then filter it with 16 layers of gauze to obtain the loofah fiber extract for subsequent use;

[0033] (2) Mix chitosan and acidic calcium chloride, add 4 ...

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Abstract

The invention discloses an air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and a preparation method of the air-permeable moisturizing dressing. The air-permeable moisturizing dressing comprises the following raw materials in parts by weight: 12-14 parts of N-trimethyl chitosan, 8-12 parts of menthanol, 5-7 parts of isopropyl myristate, 20-30 parts of chitosan, 25-35 parts of loofah sponge fibers, 8-14 parts of isomalto-oligosaccharide, 5-9 parts of polyvinyl alcohol, 6-10 parts of carboxymethyl cellulose sodium, 10-12 parts of glycerol, 8-10 parts of mannitol, 12-20 parts of medicinal powder, 3-7 parts of weak-acid calcium chloride and a proper amount of deionized water. As chitosan and loofah sponge fibers are combined together, the moisturizing property of the dressing is guaranteed by adsorbability of chitosan, and the air permeability of the dressing is guaranteed by the hollow tube bundle structures of the loofah sponge fibers; meanwhile, chitosan derivatives are used together to effectively promote percutaneous absorption and wound healing, so that a favorable effect is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a breathable and moisturizing dressing capable of inhibiting bacteria and promoting drug transdermal absorption and a preparation method. Background technique [0002] Chitosan and its derivatives can promote the growth of epithelial cells and wound healing. Chitosan can be absorbed by normal skin tissue, but the absorption capacity of injured skin tissue is greatly reduced. Studies have shown that fat-soluble substances and substances with small molecular weights are easily absorbed by the body. Therefore, for wounded tissues, it is very necessary to select low molecular weight chitosan to prepare medical dressings. Preparation of chitosan into dressings for treating wounds, there are many studies in this area, but chitosan dressings currently on the market are prone to adhesion with wounds, low moisture permeability, long healing period, tissue hyperplasia, Un...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/26A61L15/18A61L15/40A61L15/44A61L15/46
Inventor 陈贵青
Owner 扬州市旅游日用品制造总厂
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