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Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof

An adenovirus and amino acid technology, applied in the direction of viruses/bacteriophages, medical preparations containing active ingredients, viruses, etc., can solve the problem of unclear observation mechanism

Active Publication Date: 2015-12-02
GLAXOSMITHKLINE BIOLOGICALS SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the mechanism for this contradictory observation is unclear, the results raise additional questions about the safety and efficacy of vaccine applications based on human adenoviruses in healthy subjects

Method used

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  • Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
  • Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
  • Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof

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Embodiment Construction

[0089] Before the present invention is described in detail below, it is to be understood that this invention is not limited to the particular methodology, protocols and reagents described herein as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the invention, which will be limited only by the appended claims. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0090] Preferably, the terms used herein are as described in "Amultilingual glossary of biotechnological terms: (IUPAC Recommendations)", Leuenberger, H.G.W, Nagel, B. and Klbl, H. eds. (1995), Helvetica Chimica Acta, CH-4010 Basel, Switzerland) and Axel Kleemann and Jurgen Engel "Pharmaceutical Substances: Syntheses, Patents, Applications" Thieme Medical Publishing, 1999; Definitions d...

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Abstract

The present invention relates to novel adenovirus strains with an improved seroprevalence in human. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and / or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and / or the pharmaceutical composition for the therapy or prophylaxis of a disease.

Description

[0001] This application is a divisional application of an invention application with a filing date of February 2, 2010, a Chinese application number of 201080006197.X, and an invention title of "simian adenovirus nucleic acid and amino acid sequences, vectors containing them and their uses". [0002] The present invention relates to novel adenovirus strains with improved seropositivity. In one aspect, the invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fibrin, fragments thereof and polynucleotides encoding the same. Also provided are vectors comprising the isolated polynucleotides according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and pharmaceutical combinations comprising said vectors, adenoviruses, polypeptides and / or polynucleotides things. The present invention also relates to the use of isolated polynucleotides, isolated polypeptides, vectors, aden...

Claims

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Application Information

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IPC IPC(8): C12N15/34C07K14/075C12N7/01C12N15/861C12N5/10A61K39/235A61K48/00
CPCC12N15/86A61K2039/525A61K2039/5256C07K14/005C12N7/00C12N2710/10321C12N2710/10322C12N2710/10334C12N2710/10343C12N2740/16134
Inventor S.科洛卡A.尼科西亚R.科尔特塞V.安门多拉M.安布罗西奥
Owner GLAXOSMITHKLINE BIOLOGICALS SA
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