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Spirostanol saponin compounds and application thereof

A technology for spirosteroidal saponins and compounds is applied in the field of spirosteroidal saponins, which can solve the problems of insufficient research on chemical components of the open arrow, and achieve good anti-tumor effect.

Active Publication Date: 2015-12-16
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing research on the chemical composition of open arrow is still not thorough enough, so

Method used

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  • Spirostanol saponin compounds and application thereof
  • Spirostanol saponin compounds and application thereof
  • Spirostanol saponin compounds and application thereof

Examples

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Embodiment Construction

[0026] Take 17Kg of open arrow rhizome, heat and reflux with 60% ethanol to extract 4 times, each time for 4 hours, combine the extracts to recover the solvent under reduced pressure, and obtain the total extract, suspend the total extract with water, and extract with equal volume of ethyl acetate for 4 Next, fat-soluble impurities were removed, and the aqueous layer was separated by D101 macroporous resin column chromatography, and eluted with water, 20% ethanol, 60% ethanol, 80% ethanol, and 95% ethanol respectively to obtain 5 fractions TA to TE. Fraction TB (20% ethanol elution fraction) 100g was taken, and compounds 1, 4, and 5 of the present invention were obtained by separation by silica gel column chromatography, ODS medium-low pressure column chromatography, reverse-phase high-performance liquid chromatography, and other separation methods. Using the same separation means to isolate the compounds 3 and 9 of the present invention from the fraction TC (60% ethanol elutio...

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PUM

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Abstract

The invention discloses spirostanol saponin compounds and application thereof. The structural general formula of the spirostanol saponin compounds is as shown in the description. In the formula, R11 and R5 are independent H, alkane radicals of C1 to C4 or monosaccharide residues; R21 and R31 are independent H or OH; R41 is the alkane radicals of C1 to C4 or monohydric alcohol; R42 is the alkane radicals of C1 to C4. The spirostanol saponin compounds disclosed by the invention have a good antitumor function, and certain actions for nasopharyngeal cancer, liver cancer, leukemia, lung cancer and the like; the spirostanol saponin compounds have the advantages of high efficiency and low toxicity and are hopefully developed into new anticancer medicaments or functional foods or health-care foods.

Description

technical field [0001] The invention relates to a spirosteroid saponin compound and application thereof. Background technique [0002] Tumor is a new organism characterized by excessive cell proliferation produced by the cells of human organs and tissues under the long-term action of external and internal harmful factors. It can be divided into two categories: benign tumors and malignant tumors in medicine. Benign tumors have little impact on human health, while malignant tumors (also known as cancer) seriously threaten human health. According to the latest statistics from the World Health Organization and the American Cancer Society, cancer has become the leading cause of human death. In 2008, there were about 12.7 million newly diagnosed cancer cases and 7.6 million cancer deaths worldwide (accounting for about 13% of all deaths) , and approximately 70% of cancer deaths occur in low- and middle-income countries. It is estimated that by 2030, the number of annual cancer d...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61P35/00A61P35/02A23L1/30
Inventor 何祥久向丽敏王宜海
Owner GUANGDONG PHARMA UNIV
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