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Acylation flavone glycoside named camellikaempferoside A and preparing method and application thereof

A technology for acylating flavonoid glycosides and kaempferol glycosides, which is applied in the field of chemistry and achieves the effects of reducing preparation cost and simple preparation method

Active Publication Date: 2015-12-30
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are relatively few reports on the chemical basis of the bioactivity of Fuzhuan tea. If the bioactive flavonoid glycosides can be successfully researched and developed from the black tea resource of Fuzhuan tea, it will make important contributions to the fields of agriculture and medicine. contribute

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  • Acylation flavone glycoside named camellikaempferoside A and preparing method and application thereof
  • Acylation flavone glycoside named camellikaempferoside A and preparing method and application thereof
  • Acylation flavone glycoside named camellikaempferoside A and preparing method and application thereof

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Embodiment Construction

[0028] The technical solutions in the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0029] The experimental methods in the following examples are conventional methods unless otherwise specified.

[0030] The percentages in the following examples are all mass percentages unless otherwise specified.

[0031] 1. Tea kaempferoside A (camellikaempferoside A)

[0032]

[0033] Two, the preparation of tea kaempferoside A (camellikaempferosideA)

[0034] (1) Get 3.6 kilograms of Fuzhuan brick tea, and pulverize Fuzhuan brick tea;

[0035] (2) Extract pulverized Fuzhuan tea with 6 liters of acetone aqueous solution each time for 96 hours each time, and extract 3 times in total. Concentrate the obtained acetone water extract to a paste to obtain 800 grams of extract;

[0036] (3) Suspend the above-mentioned obtained extract in 2L water to obtain an aqueous suspension, w...

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Abstract

The invention discloses acylation flavone glycoside named camellikaempferoside A and a preparing method and application thereof. At first, the structure of camellikaempferoside A is provided, and then a method for separating camellikaempferoside A from Fuzhuan tea to prepare and obtain camellikaempferoside A is provided; when a monomeric compound is prepared, at first, Fuzhuan tea is taken and smashed; then organic solvent is used for extracting the smashed Fuzhuan tea, and an extracting solution is concentrated in a pressure reducing mode to prepare paste extract; the paste extract is separated and purified to obtain camellikaempferoside A. The invention further provides application of acylation flavone glycoside named camellikaempferoside A to preparation of medicine for resisting breast cancer (MCF-7 and MDA-MB-231). The acylation flavone glycoside with bioactivity has great significance in the agriculture and medicine field, and provides a wide prospect for effectively developing and utilizing the Fuzhuan tea; the preparing method is simple and low in cost.

Description

technical field [0001] The invention belongs to the field of chemical technology, and in particular relates to an acylated flavone glycoside named tea kaempferol A, a preparation method and application thereof. Background technique [0002] Camellia sinensis and its leaf processed products such as green tea, black tea, black tea, etc. contain flavonoids and flavonoid glycosides with good biological activity, which are very important natural organic compounds in nature. As early as 1991, Finger et al. identified 20 flavonoids and their glycosides from fresh tea leaves, black tea, and green tea. Zou Yanli et al. also isolated three flavonoids from Pu'er cooked tea. Therefore, it shows that tea products contain a lot of flavonoid active biological ingredients that have the functions of preventing cardiovascular disease, antibacterial, and anticancer. These natural ingredients with health care effects have attracted people's attention, and this will also become a research hotspo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61P35/00
Inventor 凌铁军田永真刘潇安茂强刘杏益张梁宛晓春张正竹
Owner ANHUI AGRICULTURAL UNIVERSITY
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