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A kind of microemulsion gel ointment for treating infantile diarrhea and preparation method thereof

A technology for microemulsion gel and infantile diarrhea, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problem of slow transdermal absorption of active ingredients and ineffective infantile diarrhea. Ideal, poor compliance of children, etc., to achieve the effect of improving compliance, significantly treating superiority, and improving absorption speed

Active Publication Date: 2019-03-05
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned powders and plasters are all traditional dosage forms, and the process is mostly prepared by crushing medicinal materials or dispersing them in fat-soluble matrices such as beeswax, vaseline, and lanolin. Children with poor compliance and other defects, the effect of treating diarrhea in children is still not very satisfactory

Method used

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  • A kind of microemulsion gel ointment for treating infantile diarrhea and preparation method thereof
  • A kind of microemulsion gel ointment for treating infantile diarrhea and preparation method thereof
  • A kind of microemulsion gel ointment for treating infantile diarrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 (preparation example of volatile oil)

[0027] Take by weighing 10kg each of the medicinal material powders (medium powder) of Amomum seed, Atractylodes atractylodes, Cinnamon and clove, add 15 times the amount of water to soak for 30 minutes, and reflux extraction at 100°C; collect volatile oils to obtain 400ml of Amomum volatile oil, Atractylodes volatile oil 150ml, cinnamon volatile oil 200ml and clove volatile oil 500ml. The obtained four kinds of volatile oils were respectively sealed and kept away from light for use in the following Examples 2-4.

Embodiment 2

[0029] (1) Prescription

[0030] (1.1) Active ingredients: Amomum volatile oil 39.8g, Atractylodes volatile oil 40.6g, cinnamon volatile oil 34.2g, clove volatile oil 55.4g. The total weight of four kinds of volatile oils in this example is 170g.

[0031] (1.2) Emulsifier: Solutol HS15 850g, 1,2-propanediol 850g.

[0032] (1.3) Substrate: NP700 1000g, PVP K90 400g, aluminum glycolate 80g, glycerol 6000g, EDTA-2Na 20g, vitamin E 100g, tartaric acid 2g, water 8130g.

[0033] (2) Preparation of paste

[0034] (2.1) Take the four kinds of volatile oils in the above-mentioned prescription quantities, mix them evenly, and prepare the active ingredients.

[0035] (2.2) Stir sodium polyacrylate, aluminum glycolate, glycerin, and vitamin E evenly to obtain component A;

[0036] (2.3) After dissolving polyvinylpyrrolidone in 6000g of water, add disodium edetate to prepare component B;

[0037] (2.4) Add the emulsifier to the active ingredient, mix well, and filter to obtain the oil...

Embodiment 3

[0041] (1) Prescription

[0042] (1.1) Active ingredients: Amomum volatile oil 27g, Atractylodes volatile oil 28g, cinnamon volatile oil 26g, clove volatile oil 43g. The total weight of the four volatile oils in this example is 124g.

[0043] (1.2) Emulsifier: Solutol HS15 660g, 1,2-propanediol 660g.

[0044] (1.3) Substrate: 840g NP700, 355g PVP K90, 68g aluminum glycolate, 5009g glycerin, 14.5g EDTA-2Na, 97g vitamin E, 1.5g tartaric acid, 9776g water.

[0045] (2) Preparation of paste

[0046] (2.1) Take the four kinds of volatile oils in the above-mentioned prescription quantities, mix them evenly, and prepare the active ingredients.

[0047] (2.2) Stir sodium polyacrylate, aluminum glycolate, glycerin, and vitamin E evenly to obtain component A;

[0048] (2.3) After dissolving polyvinylpyrrolidone in 7214g of water, add disodium edetate to prepare component B;

[0049](2.4) Add the emulsifier to the active ingredient, mix well, and filter to obtain the oil phase; mix ...

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Abstract

The invention relates to a microemulsion gel ointment for treating infantile diarrhea. The microemulsion gel ointment consists of a backing material, an ointment body which is coated on the backing material and a covering material; the ointment body is prepared from 0.5-1.4wt% of active ingredients, 6.5-12.6wt% of an emulsifier and 86.2-92.4% of a matrix, wherein the active ingredients include the following volatile oil in percentage by weight: 20.5-25.2wt% of fructus amomi volatile oil, 20.7-25.2wt% of rhizoma atractylodis volatile oil, 17.0-21.2wt% of cortex cinnamomi volatile oil and 29.1-35.4wt% of clove volatile oil; and the ointment body is prepared by adding the emulsifier to the active ingredients so as to prepare an oil phase, then adding water to prepare an O / W microemulsion, and mixing the O / W microemulsion with the residual matrix. The microemulsion gel ointment disclosed by the invention, compared with a conventional Chinese medicinal patch, has the advantages of high transdermal absorption rate of the index components, high cumulative transmittance rate, good preparation stability and good skin compatibility.

Description

technical field [0001] The present invention relates to a medicinal preparation with undetermined structure containing dicotyledonous plants of the genus Atractylodes, and also relates to a gel ointment characterized by non-effective ingredients, which can be used for treating diarrhea. Background technique [0002] Diarrhea in children is a group of common pediatric diseases caused by multiple pathogens and factors, characterized by increased stool frequency and changes in stool properties. The incidence rate of infants aged 6 months to 2 years is high, which is the cause of malnutrition and growth and development disorders in children. and one of the leading causes of death. According to the statistics of the World Health Organization (WHO), about 1 billion children under the age of 5 suffer from diarrhea every year in the world, and 4 to 5 million children die from diarrhea; a report by the United Nations in 2009 pointed out that every 5 children died In one case, one di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K36/9064A61K47/12A61K47/32A61P1/12
Inventor 张军杨帆叶炳皇朱莉刘磐银杉杉刘帝灵
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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