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Application of aleuritopteris argentea extract in preparation of medicines for treating cardiovascular and cerebrovascular diseases

A cardiovascular and cerebrovascular disease and extract technology is applied in the application field of Tongjingcao extract in the preparation of drugs for treating cardiovascular and cerebrovascular diseases, and can solve the problems of obstruction or rupture, large side effects of western medicines, and insignificant effects of traditional Chinese medicines, etc. To achieve the effect of improving utilization rate and obvious therapeutic effect

Inactive Publication Date: 2016-02-10
YUYAO WANZHEN HARDWARE FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main cause of cardiovascular and cerebrovascular diseases is caused by the abnormal metabolism of smooth muscle cells in the blood vessel wall. The blood vessel tissue and other tissues of the human body complete the metabolic process within a certain period, but due to the abnormal formation of new cell tissue, the blood vessel wall itself exists " "Defect" is therefore prone to inflammation and poor constriction of blood vessels, just like a dilapidated old pipeline, which may be blocked or ruptured at any time
At present, there are many kinds of drugs on the market to improve cardiovascular and cerebrovascular diseases or treat neck, shoulder and lumbar pain. Western medicines have large side effects, while traditional Chinese medicines are not very effective.
However, the influence of Tongjingcao on cardiovascular and cerebrovascular diseases has not yet been reported in literature and patents.

Method used

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  • Application of aleuritopteris argentea extract in preparation of medicines for treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation method of the Herb Tongjing extract is as follows:

[0021] (1) Take the grass leaves as raw materials, wash, dry, crush and sieve, put them in the extraction tank, add water and ethanol, the mass ratio of material to liquid is 1:8, and extract under pressure for 4 times at 100°C , the pressure is controlled at 12 atmospheres, each extraction is 4h, the extract is filtered, combined, ethanol is recovered, concentrated, and dried to obtain extract A;

[0022] (2) Soak the extract A in 8 times of acetone and reflux 5 times, place it in an ice bath, filter and concentrate, wait for the acetone to evaporate to dryness, freeze-dry to obtain extract B;

[0023] (3) Take the above-mentioned extract B and dissolve it in water, add a mixed solution of chloroform and n-butanol with a volume ratio of 4:1, stir and leave to stand at low temperature for stratification, and repeat the operation of the upper aqueous phase for 4 times, and use a molecular weight cut-off...

Embodiment 2

[0027] The preparation of embodiment 2 Tongjingcao extract

[0028] (1) Take the grass leaves as raw materials, wash, dry, crush and sieve, put them in the extraction tank, add water and ethanol, the mass ratio of material to liquid is 1:10, and extract under pressure for 4 times at 110°C , the pressure is controlled at 11 atmospheres, each extraction is 3.5h, the extract is filtered, combined, ethanol is recovered, concentrated and dried to obtain extract A;

[0029] (2) Soak the extract A in 14 times of n-hexane and reflux 4 times, place it in an ice bath, filter and concentrate, wait for the n-hexane to evaporate to dryness, freeze-dry to obtain extract B;

[0030] (3) Take the above-mentioned extract B and dissolve it in water, add a mixed solution of chloroform and n-butanol with a volume ratio of 4:1, leave it to stand at low temperature after stirring, and repeat the operation of the upper aqueous phase for 5 times. Dialyze with a dialysis membrane of ~10,000 for 2 day...

Embodiment 3

[0035] (1) Take Tongjing grass leaves as raw materials, after cleaning, drying, crushing and sieving, put them in the extraction tank, add water and ethanol, the mass ratio of material to liquid is 1:12, and extract under pressure for 3 times at 120°C , the pressure is controlled at 10 atmospheres, each extraction is 4h, the extract is filtered, combined, ethanol is recovered, concentrated, and dried to obtain extract A;

[0036] (2) Soak the extract A in 20 times of diethyl ether and reflux 5 times, place it in an ice bath, filter and concentrate, wait for the diethyl ether to evaporate to dryness, and freeze-dry to obtain extract B;

[0037] (3) Take the above-mentioned extract B and dissolve it in water, add a mixed solution of chloroform and n-butanol with a volume ratio of 4:1, stir and let stand at low temperature for stratification, repeat the operation of the upper aqueous phase for 7 times, and use a molecular weight cut-off of 8000 Dialyze with a dialysis membrane of...

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Abstract

The invention discloses application of an aleuritopteris argentea extract in preparation of medicines for treating cardiovascular and cerebrovascular diseases. Aleuritopteris argentea leaves are subjected to water-alcohol mixed extraction, extraction, membrane dialysis, column purification and regulation to obtain the aleuritopteris argentea extract with high activity. The aleuritopteris argentea leaves are adopted as the raw material, and effective ingredients of the aleuritopteris argentea are extracted and used for preparing medicines for treating cardiovascular and cerebrovascular diseases, so that the utilization of aleuritopteris argentea can be improved, and the treatment effect is remarkable.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicines, in particular to the application of an extract of Tongjingcao in the preparation of medicines for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Tongjingcao is the dry whole herb of the Chinese traveler plant, Argentia chinensis. Harvest in autumn, remove impurities and dry in the sun. Included in 1998 "Ministry of Health of the People's Republic of China Drug Standards Mongolian Drug Sub-volume". It is flat in nature and slightly bitter in taste, and has the effects of improving eyesight, healing wounds, stopping bleeding, promoting blood circulation and regulating menstruation, relieving cough, promoting dampness, detoxifying and reducing swelling, etc. . It is a commonly used drug in ethnic minority areas such as Tibet and Mongolia. However, the basic research on Tongjingcao is still very limited, which limits the su...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P9/00
Inventor 沈婉珍
Owner YUYAO WANZHEN HARDWARE FACTORY
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