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Application of Sorgomol in preparing monoamine oxidase (MAO) inhibitor

A monoamine oxidase and inhibitor technology, applied in the application field of Sorgomol in the preparation of MAO inhibitors of monoamine oxidase, to achieve the effect of strong inhibitory activity and outstanding substantive characteristics

Inactive Publication Date: 2016-02-17
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But because "cheesereaction" causes high blood pressure, its application is limited

Method used

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  • Application of Sorgomol in preparing monoamine oxidase (MAO) inhibitor
  • Application of Sorgomol in preparing monoamine oxidase (MAO) inhibitor
  • Application of Sorgomol in preparing monoamine oxidase (MAO) inhibitor

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Embodiment 1

[0011] Embodiment 1: the preparation of compound Sorgomol tablet involved in the present invention:

[0012] Take 5 grams of compound Sorgomol and add 195 grams of dextrin, mix well, and conventionally press into 1000 tablets.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Sorgomol capsules involved in the present invention:

[0014] Get 5 grams of the compound Sorgomol, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

[0016] Compound Sorgomol detects the inhibitory activity to MAO-A and MAO-B with the method of fluorescent probe, and described method is carried out according to the following steps:

[0017] Dissolve the sample to be tested in DMSO to prepare a series of samples with concentration gradient. Take 4ul of MAO (10mg / ml), boric acid buffer (PH=8.4), 50ul of BSA (50mg / ml), add the sample solution to be tested, mix well, react in a water bath at 30-38°C for 3h, then add probe 7- (3-Aminopropoxy)coumarin 2ul (50mmol / ml), the final concentration of the inhibitor is 0~10-2mmol / l, the mixture is then reacted in a water bath at 30±5°C for 12h, and is measured with ...

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Abstract

The invention provides application of Sorgomol in preparing a monoamine oxidase (MAO) inhibitor. Compared with an existing monoamine oxidase inhibitor, the inhibitory activity and MAO and MAO-B selectivity of the MAO inhibitor are both greatly improved. The application of Sorgomol in preparing the MAO inhibitor is disclosed for the first time, Sorgomol has strong MAO inhibitory activity and prominent substantial characteristics, and meanwhile Sorgomol obviously has remarkable progress when applied to treating diseases related to MAO disorder.

Description

technical field [0001] The present invention relates to a new application of compound Sorgomol, in particular to the application of Sorgomol in the preparation of monoamine oxidase MAO inhibitors. Background technique [0002] Since the anti-tuberculosis drug isoniazid was found to be a potential MAO inhibitor, research on MAO inhibitors has become a hot topic. Iproniazid became the first MAO inhibitor, because it was discovered that this kind of MAO inhibitor containing hydrazine structure can also inactivate P450s and cause liver toxicity; and studied the non-hydrazine MAO inhibition represented by tranylcypromine Agents, this category can be called the second generation. But because "cheesereaction" causes high blood pressure, its application is limited. Therefore, it is quite necessary and urgent to develop a newer and more efficient monoamine oxidase inhibitor. [0003] The compound Sorgomol involved in the present invention is a new compound published in 2013 (Takay...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/06A61P43/00
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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