A pharmaceutical composition for treating senile constipation and its application

A composition and senile technology, applied in the directions of drug combination, application, medical preparations containing active ingredients, etc., can solve the problems of drug-dependent constipation, constipation, repeated symptoms, etc. The effect of reducing abdominal fullness symptoms

Inactive Publication Date: 2020-06-26
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine often chooses rhubarb soda tablets, Kaisailu, mosapride and other symptomatic treatments for the treatment of senile constipation, which can often be effective at the time. However, long-term use of such drugs can easily lead to drug-dependent constipation, and constipation occurs again after stopping the drug. Repeated symptoms

Method used

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  • A pharmaceutical composition for treating senile constipation and its application
  • A pharmaceutical composition for treating senile constipation and its application
  • A pharmaceutical composition for treating senile constipation and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Chinese medicine extract

[0015] Prescription: 1.2kg of pumpkin pedicle, 0.5kg of Shangshanhu, and 0.16kg of Trichosanthes bark.

[0016] Preparation Process:

[0017] (1) Weigh the Shangshan Tiger of the prescribed amount, reflux extraction with absolute ethanol for 3 times, the amount of ethanol is 8L each time, the time is 2h, filter, combine the filtrate, and the obtained filtrate is concentrated at 0.07MPa under reduced pressure to 65°C The density is 1.25, and ethanol is recovered to obtain a concentrated solution, and the concentrated solution is spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the spray speed 5ml / s), pulverized through 80 mesh sieve, to obtain alcohol extract;

[0018] (2) Weigh the pumpkin pedicle and Trichosanthes chinensis skin in the prescribed amount, add water to decoct and ex...

Embodiment 2

[0021]

[0022] Preparation process: dry powder of Chinese medicine extract in the prescription (prepared in Example 1), vitamin K 2 , sodium carboxymethyl cellulose, tragacanth gum, sucrose and sodium citrate, passed through a 100-mesh sieve respectively, weighed according to the prescription amount, mixed evenly, added 10% starch slurry to make a soft material, and made through a 14-mesh sieve After granulation, dry at about 80°C, then sieve the granules with a 12-mesh sieve, and divide them into 15g packages. Clinical application example

[0023] According to the diagnostic criteria for chronic constipation in the series of diagnostic criteria for Rome Ⅱ functional gastrointestinal diseases formulated by the International Rome Ⅱ Collaborative Committee on the basis of Rome Ⅰ in September 1999, 94 cases of senile constipation were diagnosed, aged 55-72 years old, with an average of (63.7±8.6) years old, 74 males and 20 females. They were randomly divided into experiment...

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Abstract

The invention discloses a pharmaceutical composition for treating senile constipation and application thereof. The composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 40-70 parts of cushaw base, 21-30 parts of root of ilex ficoidea and 6-11 parts of snakegourd peel. The pharmaceutical composition disclosed by the invention can promote gastrointestinal motility, remarkably shorten the defecation interval and alleviate the symptom of abdominal distension, thus achieving the aim of curing the senile constipation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating senile constipation and its application. Background technique [0002] Constipation is a common symptom of elderly patients. About 35% of the elderly have this symptom. The frequency of defecation in patients with constipation is significantly less than that of normal people. At the same time, it is difficult to defecate, dry stool, intestinal diseases and other systemic diseases can cause it. Constipation The incidence of esophageal cancer increases with age, and brings many harms to the elderly, such as anal fissure, hemorrhoids, multiple abdominal pain, and rectal cancer, which seriously affect the quality of life of patients, and even induce and aggravate cardiovascular and cerebrovascular diseases, resulting in sudden death . Western medicine often chooses rhubarb soda tablets, Kaisailu, mosapride and other sym...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/428A61P1/10A23L33/105
CPCA23V2002/00A61K9/1652A61K36/185A61K36/42A61K36/428A61K2300/00A23V2200/30A23V2200/32A23V2250/21
Inventor 贺延新李凤月娄渊贵
Owner QINGDAO CENT HOSPITAL
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