Preparation method of slow-released norfloxacin injection

A technology for slow-release norfloxacin and norfloxacin, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. problem, to achieve the effect of prolonging the release time

Inactive Publication Date: 2016-04-20
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defects of the prior art, and provides a preparation method capable of prolonging the half-life of norfloxacin injection, so as to solve the need for repeated medication in the treatment process of long-duration animal diseases in the prior art, and increase the emergency response time of animals. and increase the cost of farming

Method used

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  • Preparation method of slow-released norfloxacin injection

Examples

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Effect test

Embodiment 1

[0027] Preparation of 5% norfloxacin n-hexanoate injection

[0028] Take 5g norfloxacin (pure) and 40g N,N-dimethylacetamide, stir and dissolve until clear, add 1g of n-hexanoic acid and slowly stir for complexation for 1h, add 5g fatty acid glycerides and continue stirring until clear, N,N -Dimethylacetamide was adjusted to 100ml, and filtered with a 0.45 μm organic membrane to obtain 5% norfloxacin injection.

Embodiment 2

[0030] Preparation of 10% norfloxacin laurate injection

[0031] Take 10g of norfloxacin (Zhechun) and 40g of propylene glycol, stir and dissolve until clear, add 2g of lauric acid and slowly stir for complexation for 2h, add 10g of glycerin fatty acid ester and continue stirring until clear, dilute the volume of propylene glycol to 100ml, and use 0.45μm Filter through an organic membrane to obtain 10% norfloxacin laurate injection.

Embodiment 3

[0033] Preparation of 15% Norfloxacin Palmitate Injection

[0034] Take 15g norfloxacin (pure) and 40g 2-pyrrolidone, stir and dissolve until clear, add 3g of palmitic acid and slowly stir for complexation for 3h, add 20g polyvinylpyrrolidone and continue stirring until clear, 2-pyrrolidone is constant to 100ml, filtered through a 0.45μm organic membrane to obtain 15% Norfloxacin Palmitate Injection.

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Abstract

The invention provides a preparation method of a slow-released norfloxacin injection, and belongs to a slow-released injection for animals. The norfloxacin injection is prepared from, by weight, 5%-20% of norfloxacin, 1%-4% of fatty acid, 5%-35% of stabilizer and the balance organic solvent. The preparation method comprises the steps that norfloxacin and the organic solvent are taken and stirred for dissolution, the fatty acid is added to conduct a complexation reaction with a dissolved product, the stabilizer is added, after sufficient dissolution is achieved, the organic solvent is added for the scale volume, and the slow-released norfloxacin injection is obtained after membrane filtration is conducted. According to the preparation method of the slow-released norfloxacin injection, norfloxacin or a salt hydrate thereof is reacted with the fatty acid to form a new compound, the release time of norfloxacin can be prolonged, the effective blood drug concentration of a drug in an animal body can be maintained for a long time, and therefore the purposes of decreasing the frequency of drug delivery and reducing drug stress are achieved.

Description

technical field [0001] The invention relates to a preparation method of veterinary injection, in particular to a preparation method of sustained-release norfloxacin injection. Background technique [0002] Norfloxacin (Norfloxacin, also known as Noroxin, Fulgram), aliases: Lijuro, Norfloxacin, Linbuxing, its chemical name is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo Substitute-7-(1-piperazinyl)-3-quinolinecarboxylic acid. It is a second-generation quinolone antibacterial drug. Its effect is to hinder the DNA helicase of pathogenic bacteria in the digestive tract, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. It is a commonly used drug for the treatment of enteritis, dysentery and urinary tract infections. [0003] In recent years, my country's livestock and poultry breeding industry has been frequently plagued by large-scale respiratory and digestive tract infectious diseases, and respiratory and digestive tract diseases usually have the characterist...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/48A61K31/496A61P31/04A61P1/12A61P13/00
CPCA61K9/0019A61K9/0002A61K9/08A61K31/496
Inventor 董萌萌付旭彬杨保收梁武
Owner TIANJIN RINGPU BIO TECH
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