Phenolphthalein tablets for treating constipation and preparation method thereof

Abstract

The invention relates to phenolphthalein tablets for treating constipation and a preparation method thereof. The phenolphthalein tablets are prepared from phenolphthalein, active ingredients of traditional Chinese medicine, starch, 10% starch slurry, magnesium stearate and sodium dodecyl sulfate; the raw materials are taken, granulation is performed according to a conventional method, and five hundred thousand tablets are prepared. The phenolphthalein tablets are remarkable in constipation curative effect, treat both symptoms and root causes and have the wide application prospect.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a phenolphthalein tablet for treating constipation and a preparation process thereof. Background technique

[0002] With the change of diet structure and the interference of mental and psychological factors, constipation has become one of the important factors affecting the quality of life of modern people. However, the current clinical concept of whether constipation is a disease or a disease is quite confusing. In the International Classification of Diseases, "constipation" is a disease. There are many opinions on whether "constipation" is a disease or a disease in domestic medical circles, and there is a lack of unified understanding. Researchers or clinicians are at a loss.

[0003] Constipation is a difficult and complicated clinical problem. With the rapid development of modern science and technology in recent years and the continuous integration with modern m...

Examples

Embodiment 1

[0029] Phenolphthalein tablets for treating constipation, which are prepared from the following raw materials:

[0030] 50kg of phenolphthalein, 25kg of starch, 20kg of 10% (by weight) starch slurry, 0.77kg of magnesium stearate, 0.23kg of sodium dodecyl sulfonate

[0031] Get above-mentioned raw material, granulate according to conventional method, prepare 500,000 tablets.

Embodiment 2

[0033] Phenolphthalein tablets for treating constipation, which are prepared from the following raw materials:

[0034] 18kg of phenolphthalein, 25kg of active ingredients of traditional Chinese medicine, 25kg of starch, 22kg of 10% (by weight) starch slurry, 0.77kg of magnesium stearate, 0.23kg of sodium dodecylsulfonate

[0035] Get above-mentioned raw material, granulate according to conventional method, prepare 500,000 tablets.

[0036] The active ingredient of the traditional Chinese medicine is prepared from the raw materials of the following weight:

[0037] 35 parts of cistanche, 35 parts of big belly skin, 35 parts of cassia seed, 35 parts of dandelion, 35 parts of almond,

[0038] 30 parts of privet fruit, 30 parts of mulberry fruit, 30 parts of turmeric, 30 parts of melon, 30 parts of aurantium,

[0039] 25 parts of Artemisia annua, 25 parts of Burdock, 25 parts of Cortex Phellodendri, 25 parts of Baibu, 25 parts of Angelica,

[0040] 20 parts of tangerine peel, 20...

Embodiment 3

[0052] Acute toxicity test: 60 mice, half male and half female, weighing 30-40 g, were used for acute toxicity test. The mice were randomly divided into two groups, i.e. the control group and Example 1 group, Example 2 group, 20 in each group, fasted for 12 hours before the experiment, and the administration group was given the preparation of Example 1 and Example 2 of the present invention respectively. The pharmaceutical composition was dissolved in water for intragastric administration, and the control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations. After administration, the mice were continuously observed for two weeks, and the toxic reactions and symptoms of the mice were recorded. deaths. The experimental results showed that: compared with the control group, there was no significant difference in the mice after administration. The experiment was observed for two consecutive weeks, and the ge...

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a phenolphthalein tablet for treating constipation and a preparation process thereof. Background technique

[0002] With the change of diet structure and the interference of mental and psychological factors, constipation has become one of the important factors affecting the quality of life of modern people. However, the current clinical concept of whether constipation is a disease or a disease is quite confusing. In the International Classification of Diseases, "constipation" is a disease. There are many opinions on whether "constipation" is a disease or a disease in domestic medical circles, and there is a lack of unified understanding. Researchers or clinicians are at a loss.

[0003] Constipation is a difficult and complicated clinical problem. With the rapid development of modern science and technology in recent years and the continuous integration with modern m...

Examples

Embodiment 1

[0029] Phenolphthalein tablets for treating constipation, which are prepared from the following raw materials:

[0030] 50kg of phenolphthalein, 25kg of starch, 20kg of 10% (by weight) starch slurry, 0.77kg of magnesium stearate, 0.23kg of sodium dodecyl sulfonate

[0031] Get above-mentioned raw material, granulate according to conventional method, prepare 500,000 tablets.

Embodiment 2

[0033] Phenolphthalein tablets for treating constipation, which are prepared from the following raw materials:

[0034] 18kg of phenolphthalein, 25kg of active ingredients of traditional Chinese medicine, 25kg of starch, 22kg of 10% (by weight) starch slurry, 0.77kg of magnesium stearate, 0.23kg of sodium dodecylsulfonate

[0035] Get above-mentioned raw material, granulate according to conventional method, prepare 500,000 tablets.

[0036] The active ingredient of the traditional Chinese medicine is prepared from the raw materials of the following weight:

[0037] 35 parts of cistanche, 35 parts of big belly skin, 35 parts of cassia seed, 35 parts of dandelion, 35 parts of almond,

[0038] 30 parts of privet fruit, 30 parts of mulberry fruit, 30 parts of turmeric, 30 parts of melon, 30 parts of aurantium,

[0039] 25 parts of Artemisia annua, 25 parts of Burdock, 25 parts of Cortex Phellodendri, 25 parts of Baibu, 25 parts of Angelica,

[0040] 20 parts of tangerine peel, 20...

Embodiment 3

[0052] Acute toxicity test: 60 mice, half male and half female, weighing 30-40 g, were used for acute toxicity test. The mice were randomly divided into two groups, i.e. the control group and Example 1 group, Example 2 group, 20 in each group, fasted for 12 hours before the experiment, and the administration group was given the preparation of Example 1 and Example 2 of the present invention respectively. The pharmaceutical composition was dissolved in water for intragastric administration, and the control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations. After administration, the mice were continuously observed for two weeks, and the toxic reactions and symptoms of the mice were recorded. deaths. The experimental results showed that: compared with the control group, there was no significant difference in the mice after administration. The experiment was observed for two consecutive weeks, and the ge...