A hydrogel dressing for stem cell therapy

A hydrogel and stem cell technology, applied in the field of medicine, can solve the problems of not being able to maintain the state of stem cells, which is not conducive to the proliferation and differentiation of stem cells, so as to achieve the effect of promoting wound healing, facilitating adhesion and proliferation, and realizing the effect of safe application

Active Publication Date: 2019-01-01
合肥生命谷科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of the internal space of the hydrogel and the existence of cells in a free state, this technology can neither maintain a good state of stem cells, nor is it conducive to the proliferation and differentiation of stem cells, so as to better release active factors that promote wound repair
At the same time, the stem cells in this method will inevitably come into direct contact with the skin, and there are still potential safety risks.

Method used

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  • A hydrogel dressing for stem cell therapy
  • A hydrogel dressing for stem cell therapy
  • A hydrogel dressing for stem cell therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The structure diagram of hydrogel dressing (chitosan) is shown in figure 1 . in, figure 1 -a shows the top view of the porous hydrogel dressing, figure 1 -b shows the cross-sectional view of the porous hydrogel dressing. Micropores are made on the surface of the hydrogel, and a layer of hydrogel remains at the bottom of the holes to isolate it from the wound. Before the dressing is used, only stem cells need to be seeded on the upper surface of the hydrogel, which can be applied to wound repair. On the one hand, the pore-shaped hydrogel dressing is conducive to the survival, growth and reproduction of stem cells in the pores, forming cell colonies, maintaining cell activity and the expression and release of biologically active substances; The glue is completely isolated from the skin, avoiding the safety problems caused by direct contact between stem cells and the human body.

[0037]Surface modification of the hydrogel dressing: prepare a certain concentration (1 ...

Embodiment 2

[0044] The structure of the hydrogel dressing (polyvinyl alcohol) is a groove-shaped hydrogel dressing, and the structural diagram is shown in Figure 5 (top view). Microgrooves are made on the upper surface of the hydrogel, and a layer of hydrogel remains at the bottom of the groove to isolate it from the wound. Before the dressing is used, only stem cells need to be seeded on the upper surface of the hydrogel, which can be applied to wound repair. On the one hand, the trough-shaped hydrogel dressing is conducive to the survival, growth and reproduction of stem cells in the trough, forming cell colonies, maintaining cell activity and the expression and release of biologically active substances; The glue is completely isolated from the skin, avoiding the safety problems caused by direct contact between stem cells and the human body.

[0045] Surface modification of the hydrogel dressing: prepare a certain concentration (10 mg / mL) of a hydrogel containing a photoactive group ...

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Abstract

The present invention provides a hydrogel dressing for stem cell therapy. The hydrogel dressing provided by the present invention includes a hydrogel layer and a hydrogel modification layer, and the material used in the hydrogel modification layer is gelatin containing photoactive groups. The hydrogel dressing of the invention is beneficial to the adhesion and proliferation of stem cells, and the stem cells can release the active factors that promote the growth and repair of the wound surface to the wound surface through the structure, and at the same time, the direct contact between the stem cells and the wound surface is avoided, and the safe application of the stem cells is realized.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hydrogel dressing for stem cell therapy. Background technique [0002] The skin is the largest organ in the human body with a total surface area of ​​approximately 1.5-2.0m 2 , to protect and support the body. Once the skin is damaged due to burns, wounds, ulcers, etc., the body will lose a lot of water, electrolytes, proteins, etc., and at the same time it is vulnerable to damage from bacteria and the external environment. [0003] In recent years, stem cells with the potential of self-renewal, high proliferation and multi-lineage differentiation have gradually become the focus of research on wound healing and repair. Stem cells (such as bone marrow mesenchymal stem cells, adipose mesenchymal stem cells, etc.) are a type of cells with self-renewal, multidirectional differentiation and high proliferation capabilities. They can effectively sense the surrounding microenvironment, and ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/0775A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0038A61L26/0057A61L26/008A61L2300/414
Inventor 章培标高田林崔巍巍王宗良王宇李林龙
Owner 合肥生命谷科技有限公司
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