Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of a kind of notoginseng root transformed saponin in the preparation of antifungal Epidermophyton flocculus, Trichophyton rubrum, and Trichophyton mentagrophytes

A technology of Epidermophyton flocculus and Trichophyton rubrum, applied in antifungal agents, drug combinations, drug delivery, etc., can solve problems such as human and environmental hazards, safety and environmental pollution, and unstable product output. Achieve the effect of not easy to relapse, obvious effect, and accelerated dermatophyte

Active Publication Date: 2021-08-17
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high-temperature acid treatment or alkaline treatment requires the application of acid and alkali, which itself has problems such as safety and environmental pollution; although microbial degradation treatment and enzyme treatment have mild conditions, the product output is unstable; chemical chromatography often uses organic solvents , more harmful to the human body and the environment to be eliminated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of a kind of notoginseng root transformed saponin in the preparation of antifungal Epidermophyton flocculus, Trichophyton rubrum, and Trichophyton mentagrophytes
  • Application of a kind of notoginseng root transformed saponin in the preparation of antifungal Epidermophyton flocculus, Trichophyton rubrum, and Trichophyton mentagrophytes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] like figure 1 The preparation method of shown notoginseng conversion saponin spectrum is as follows:

[0033] (1) Total saponins from Panax notoginseng were treated at a high temperature in an autoclave for 2 hours at a temperature of 120°C;

[0034] (2) After dissolving in appropriate distilled water, purifying and enriching by HP-20 macroporous resin, eluting with water and 95% ethanol water respectively, and the elution volume is 5 column volumes;

[0035] (3) collecting 95% ethanol elution components, rotary evaporation temperature 50 ℃, vacuum degree 0.02Pa, rotary evaporation to odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the Panax notoginseng saponins .

[0036] (4) Notoginseng transformed saponins obtained by processing: Pk 3 24.9%, Rh 4 35.5%, Rh 5 The content of rare saponins such as 20.2% is greatly increased, and the content of rare ginsenosides after transformation is more than 70%.

Embodiment 2

[0038] The preparation method of Panax notoginseng transformed saponins, comprising the following steps:

[0039] (1) Panax notoginseng total saponins were treated at high temperature in an autoclave for 5 hours at a temperature of 140°C;

[0040] (2) After being dissolved in appropriate distilled water, purified and enriched by HP-20 macroporous resin, eluted with water and 95% ethanol water respectively, and the elution volume is 1 column volume;

[0041] (3) collecting 95% ethanol elution components, rotary evaporation temperature of 80 ° C, vacuum degree of 0.1 MPa, rotary evaporation to tasteless, freeze-drying, and obtaining 95% ethanol water elution solid component powder; obtaining the Panax notoginseng saponins .

Embodiment 3

[0043] The preparation method of Panax notoginseng transformed saponins, comprising the following steps:

[0044] (1) Total saponins from Panax notoginseng were treated at high temperature in an autoclave for 3.5 hours at a temperature of 130°C;

[0045] (2) After being dissolved in appropriate distilled water, purified and enriched by HP-20 macroporous resin, eluted with water and 95% ethanol water respectively, and the elution volume is 3 column volumes;

[0046] (3) collecting 95% ethanol elution components, rotary evaporation temperature 60 ℃, vacuum degree 0.06MPa, rotary evaporation to odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the Panax notoginseng saponins .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of transformed saponins from notoginseng roots in the preparation of antifungal medicines for Epidermophyton flocculus, Trichophyton rubrum and Trichophyton mentagrophytes, which comprises transformed saponins from notoginseng roots and conventional pharmaceutical auxiliary materials. The main preparation steps of notoginseng converted saponins include: high temperature treatment, rotary steaming, macroporous resin purification enrichment and elution; the composition includes the following components in parts by weight: notoginseng converted saponins 0.5-50, and conventional medicinal Excipients or nursing excipients 50‑99.5; have good antibacterial and bactericidal effects. The medicine and skin care product of the present invention fundamentally kills pathogenic fungi, has significant curative effects on tinea manuum, athlete's foot, oral ulcers and black nails caused by skin fungi, and is a pure traditional Chinese medicine combination product that is safe and has no side effects .

Description

technical field [0001] The invention relates to a pharmaceutical preparation for skin, in particular to the application of a transformed saponin of Panax notoginseng in the preparation of medicines for the treatment of antifungal Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes. Background technique [0002] Dermatophytes are a group of pathogenic fungi that invade the keratinous tissues of the human body, such as skin, hair and nails, causing tinea corporis, athlete's foot, or black nails. According to statistics from the World Health Organization (WHO), a quarter of the world's population is affected by dermatophytes, and a survey in southern my country found that the incidence of tinea pedis among the population was as high as 60%, among which flocculent epidermis Ringworm, Trichophyton rubrum, and Trichophyton mentagrophytes are the main causes of beriberi, onychomycosis, tinea corporis, and tinea cruris. Pathogenic bacteria are mainly infect...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K31/704A61K9/06A61K9/12A61K8/97A61K8/60A61Q19/00A61Q17/00A61P31/10A61P17/00A61K8/9789
CPCA61K8/602A61K8/97A61K9/0014A61K9/06A61K9/12A61K31/704A61K36/258A61K47/10A61K47/42A61K2236/51A61K2236/55A61K2800/10A61Q17/005A61Q19/00
Inventor 任贵兴薛鹏杨修仕么杨
Owner INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com