Wind-cold-damp arthralgia knee osteoarthritis model establishment method, device and method of use
A knee osteoarthritis and model building technology, applied in veterinary surgery, veterinary instruments, medical science, etc., can solve the problem of difficult to express the effect of drugs efficiently and intuitively, fails to reflect the overall concept and dialectical treatment, and unfavorable drugs Test and other issues to achieve the effect of improving efficiency, accuracy, repeatability, and overcoming severe trauma
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[0031] In the following, the present invention will be described in detail and specifically through specific examples, so as to better understand the present invention, but the following examples do not limit the scope of the present invention.
[0032] 1. Embodiment
[0033] This embodiment provides a method for establishing a model of rat knee osteoarthritis of wind-cold-damp arthralgia type, comprising: Step 1, cutting off the anterior cruciate ligament of the rat knee joint to cause joint instability; Step 2, after 2 weeks, treating Step 1 The rats were placed in ice water for 1 hour of exercise every day for 4 consecutive weeks to obtain the knee osteoarthritis model of wind-cold-dampness type. The index detection methods in the second step include: observing the general shape of the articular cartilage with the naked eye, toluidine blue staining, type II collagen immunohistochemical staining, and RT-PCR detection to detect the expression of aggrecan and type II collagen ...
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