Medicine carrying punctual plug

A lacrimal canaliculus and drug-carrying technology, applied in the field of lacrimal canaliculi, can solve the problems of tear stasis, easy to cause inflammation, lacrimal canaliculus obstruction, etc., and achieve the effects of preventing lacrimal ductitis, alleviating inflammation, and preventing the phenomenon of orbital epiphora.

Active Publication Date: 2016-07-20
YIPURUN SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing canaliculus embolus completely blocks the canaliculus, caus

Method used

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  • Medicine carrying punctual plug
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  • Medicine carrying punctual plug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as Figure 1a and Figure 1bAs shown, the drug-loaded lacrimal canaliculus plug 100 includes a cylindrical body 101 extending along a central axis, and one end of the body 101 has a fixing snap ring 102 extending radially outward from the body 101, and the fixing snap ring 102 is penetrated A plurality of tear holes 103 extend. After the drug-loaded canaliculus plug 100 of the present invention is implanted in the canaliculus, the fixing clasp 102 is located at the proximal end of the canaliculus, that is, close to the eyeball, and plays a role of fixing in the canaliculus to prevent drug-loaded The canaliculus plug 100 is flushed away by the tear fluid. The extension length of the fixing snap ring 102 along the central axis is 0.1 mm-0.3 mm, and the outer diameter of the fixing snap ring 102 is 0.1 mm-0.4 mm larger than that of the main body 101 to better play a fixing role. The tear holes 103 are through holes, which are evenly distributed on the fixing ring 10...

Embodiment 2

[0034] Such as figure 2 As shown, the drug-loaded canaliculus plug 200 includes a cylindrical main body 201 extending along a central axis, and one end of the main body 201 has a fixing clasp 202 extending radially outward from the main body 201, and passes through the fixing clasp 202 There are a plurality of tear holes 203 extending, the other end of the main body 201 has another fixing snap ring 204 extending radially outward from the main body 201 , and a plurality of tear holes 205 extend through the other fixing snap ring 204 . When the drug-loaded lacrimal canaliculus plug 200 of the present invention is implanted in the lacrimal canaliculus, the fixing clasp 202 is at the proximal end of the lacrimal canaliculus, that is, close to the eyeball, and the other fixing clasp 204 is at the distal end of the lacrimal canaliculus, that is, far away from the eyeball. The position of the eyeball, both play a role in fixing the canaliculus, preventing the drug-loaded canaliculus...

Embodiment 3

[0036] As shown in FIG. 3, the drug-loaded punctal plug 300 includes a cylindrical body 301 extending along a central axis. A tear hole 303 extends through the main body 301 . The tear hole 303 is a through hole formed as a tapered hole extending along the central axis. After the drug-loaded lacrimal plug 300 of the present invention is implanted in the lacrimal canaliculus, the excess tears in the eye will pass through the epiphora 303, then flow to the nasolacrimal duct along the inner conical surface of the main body 301, and finally flow from the nasolacrimal duct In order to prevent excessive tears stagnation in the lacrimal canaliculus caused by lacrimal duct inflammation, while preventing the appearance of orbital epiphora. The conical bottom of the tapered hole is far away from the proximal end of the lacrimal canaliculus. When excess tear fluid is discharged, the tapered hole can make the tear fluid flow quickly to the nasolacrimal duct without retention. The cone t...

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Abstract

The invention relates to a medicine carrying punctual plug, which comprises a cylindrical main body extending along a center shaft, wherein the main body is formed by biodegradable polymer materials; medicine grooves are formed in the surface of the main body; and antibiotic medicine and biodegradable polymers are mixed and are contained in the medicine carrying grooves. The medicine carrying punctual plug has the advantages that the release of the antibiotic medicine is controlled through the biodegradable polymers; and the medicine can be released in a long treatment period such as half a month or one month according to a certain release curve such as uniform release, or release in a release speed regulating mode according to the disease condition of xerophthalmia or the release in a mode that that the release speed is high when the medicine carrying punctual plug is implanted into the lacrimal duct for a short time, and then the release speed is decelerated along with the disease symptom relief in future. After the xerophthalmia is relieved, the medicine carrying punctual plug starts to gradually degrade; and finally, carbon dioxide and water are generated and are discharged out from the nasolacrimal canal, so that the inflammation can be effectively relieved.

Description

technical field [0001] The present invention relates to a lacrimal canaliculus, more specifically to a drug-loaded lacrimal canaliculus plug. Background technique [0002] Dry eye syndrome refers to the general term for various diseases caused by abnormal tear quality or quantity or abnormal dynamics caused by any reason, resulting in decreased tear film stability, accompanied by ocular discomfort and ocular surface tissue lesions, also known as keratoconjunctival dryness disease. Common symptoms include dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, and sensitivity to external stimuli; sometimes the eyes are too dry, and there is basically insufficient tear fluid, which stimulates the reflex In severe cases, the eyes will be red and swollen, congested, keratinized, and the corneal epithelium is broken and there are filaments adhered. This kind of damage can cause keratoconjunctival lesions and af...

Claims

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Application Information

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IPC IPC(8): A61F9/00A61M37/00
Inventor 黄彬谢建李建军
Owner YIPURUN SHANGHAI BIOTECH CO LTD
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