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Preparation method of compound preparation for treating high blood pressure

A compound preparation and high blood pressure technology, which is applied in the field of preparation of compound preparations for the treatment of hypertension, can solve the problems of unsatisfactory effect, difficulty in taking into account various aspects of curative effect, poor adaptability of patients, etc., and achieve a non-toxic and side effect, comprehensive curative effect and remarkable effect Effect

Inactive Publication Date: 2016-07-20
QINGDAO BAIRUIJI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, the current treatment of hypertension often requires the use of multiple drugs, which is not only difficult to take into account the curative effect, but also poor patient adaptability.
However, it is difficult to realize the one-time administration of multiple drugs, and even if the effect can be realized, it is not ideal enough.

Method used

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  • Preparation method of compound preparation for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] 0.02 parts of curcumin, 10 parts of β-cyclodextrin, 20 parts of astragalus, 10 parts of Achyranthes bidentata,

[0029] Buckwheat 5 parts, Prunella vulgaris 15 parts, tulip 10 parts, chitosan 60 parts.

[0030] Preparation Process:

[0031] (1) Take β-cyclodextrin, add water and grind it into a paste; take curcumin, add enough ethanol, ultrasonically dissolve, and then add it dropwise to the above-mentioned paste β-cyclodextrin, grind while dropping, after the dropwise addition Continue grinding, grinding time 20-40min, dry to get curcumin inclusion compound;

[0032] (2) Weigh Radix Astragali, Achyranthes bidentata, Buckwheat, Prunella vulgaris and Tulip in proportion, add 60-80% ethanol of 6-10 times the volume to reflux and extract twice, each time for 2 hours, to obtain alcohol extraction residue and extract, Concentrate the extract to obtain an alcohol extract, which is set aside;

[0033] (3) remove the above-mentioned ethanol extraction...

Embodiment 2

[0037] prescription:

[0038] 0.02 parts of curcumin, 20 parts of α-cyclodextrin, 30 parts of astragalus, 20 parts of Achyranthes bidentata,

[0039] 15 parts of buckwheat, 25 parts of Prunella vulgaris, 30 parts of tulip, 120 parts of sodium carboxymethyl cellulose.

[0040] Preparation Process:

[0041] (1) Take or α-cyclodextrin, add water and grind it into a paste; take curcumin, add enough ethanol, ultrasonically dissolve, and then add it dropwise to the above-mentioned α-cyclodextrin paste, grind while dripping, dropwise Then continue to grind, the grinding time is 20-40min, and dry to obtain curcumin inclusion compound;

[0042] (2) Weigh Radix Astragali, Achyranthes bidentata, Buckwheat, Prunella vulgaris and Tulip in proportion, add 60-80% ethanol of 6-10 times the volume to reflux and extract twice, each time for 2 hours, to obtain alcohol extraction residue and extract, Concentrate the extract to obtain an alcohol extract, which is set aside;

[0043] (3) remove...

Embodiment 3

[0047] prescription:

[0048] 0.02 parts of curcumin, 10-20 parts of α-cyclodextrin, 20-30 parts of astragalus, 10-20 parts of Achyranthes bidentata,

[0049] Buckwheat 5-15 parts, Prunella vulgaris 15-25 parts, tulip 10-30 parts, ethyl cellulose 60-120 parts.

[0050] Preparation Process:

[0051] (1) Take α-cyclodextrin, add water and grind it into a paste; take curcumin, add enough ethanol, ultrasonically dissolve it, then add it dropwise to the above-mentioned α-cyclodextrin paste, grind it while dropping, after the dropwise addition Continue grinding, grinding time 20-40min, dry to get curcumin inclusion compound;

[0052] (2) Weigh Radix Astragali, Achyranthes bidentata, Buckwheat, Prunella vulgaris and Tulip in proportion, add 60-80% ethanol of 6-10 times the volume to reflux and extract twice, each time for 2 hours, to obtain alcohol extraction residue and extract, Concentrate the extract to obtain an alcohol extract, which is set aside;

[0053] (3) remove the abo...

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Abstract

The invention provides a preparation method of a compound preparation for treating high blood pressure.The preparation method comprises the following steps that 1, cyclodextrin is taken and ground into paste by adding water, curcumin is taken and ultrasonically dissolved by adding a sufficient amount of ethyl alcohol, the obtained solution is dropwise added into the cyclodextrin paste, grinding is performed while the solution is dropwise added and continuously performed after dropwise adding is finished, drying is performed, and a curcumin inclusion complex is obtained; 2, milkvetch roots, radix achyranthis bidentatae, buckwheat, spica prunellae and flowers of common tulip are weighed in proportion and extracted by adding ethyl alcohol to obtain alcohol extracting residues and an extracting solution, and the extracting solution is concentrated to obtain an alcohol extracting solution for standby application; 3, the alcohol extracting residues are removed, extraction is performed by adding pure water, and an extracting solution is concentrated to obtain a water extracting solution for standby application; 4, a framework material is dissolved, the alcohol extracting solution and the water extracting solution are added into the dissolved framework material, and high-speed dispersing, concentrating and drying are performed to obtain a compound; 5, the curcumin inclusion complex and the compound are mixed to be uniform, and then the compound preparation is obtained.Compared with the prior art, the preparation method has the advantages that the technology is simple, one-time use of multiple drugs is achieved, and the effect is significant.

Description

technical field [0001] The invention relates to a preparation method of a compound preparation for treating hypertension, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range with changes in the internal and external environment. In the whole population, the blood pressure level gradually increases with age, especially the systolic blood pressure, but the diastolic blood pressure shows a downward trend after...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P9/12A61K31/12
CPCA61K31/12A61K36/21A61K36/481A61K36/536A61K36/70A61K36/896A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 不公告发明人
Owner QINGDAO BAIRUIJI BIOTECH
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