Gliquidone-containing medicine combination for treating diabetes and preparation method thereof

A technology of gliquidone and composition, which is applied in the field of pharmaceutical composition for treating diabetes and its preparation, can solve problems such as restricting the use of gliquidone, and achieve the effect of improving therapeutic effect, less side effects, and lowering blood sugar

Inactive Publication Date: 2016-07-27
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of treating obese diabetes is very good, so it is widely used clinically. The common adverse reactions of gliquidone are gastrointestinal reactions, such as nausea, vomiting, diarrhea, abdominal pain, constipation, abdominal distension, indigestion, heartburn, etc. These adverse reactions are as high as 25%, and this adverse reaction limits the use of gliquidone

Method used

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  • Gliquidone-containing medicine combination for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0039] 30g of gliquidone, 6000g of dill seedlings, 6000g of stalks, 6000g of peach gum, 6000g of cold water flowers through stems.

[0040] The preparation method of the pharmaceutical composition for treating diabetes:

[0041] a. Add dill seedlings, reed pedicles, peach gum, and cold water flowers through the stems to decoct twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, and decoct Boil for 1 hour, combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043...

Embodiment 2

[0047] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0048] 20g of gliquidone, 7000g of dill seedlings, 5000g of stalks, 7000g of peach gum, and 5000g of cold water flowers through stems.

[0049] The preparation method of the pharmaceutical composition for treating diabetes:

[0050] a. Add dill seedlings, reed pedicles, peach gum, and cold water flowers through the stems to decoct twice, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct Cook for 1.5 hours, combine the decoction liquid, and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry po...

Embodiment 3

[0056] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0057] 40g of gliquidone, 5000g of dill seedlings, 7000g of stalks, 5000g of peach gum, and 7000g of cold water flowers through stems.

[0058] The preparation method of the pharmaceutical composition for treating diabetes:

[0059] a. Add dill seedlings, reed pedicles, peach gum, and cold water flowers through the stems to decoct twice, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct Boil for 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a gliquidone-containing medicine combination for treating diabetes and a preparation method thereof.The gliquidone-containing medicine combination for treating diabetes is prepared from, by weight, 15-45 parts of gliquidone, 4,000-8,000 parts of seedlings of dill, 4,000-8,000 parts of leaf base of chequershaped indocalamus, 4,000-8,000 parts of gum peach and 4,000-8,000 parts of pilea pumila.The traditional Chinese medicine and gliquidone are combined, the common gastrointestinal tract adverse reactions to gliquidone can be avoided, and the treatment effect on diabetes can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing gliquidone for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of insu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/10A61K31/64
CPCA61K36/23A61K9/1652A61K31/64A61K36/185A61K36/73A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 刘芳
Owner JINAN BANGWEN MEDICAL TECH
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