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Medicine composition containing melbine for treating diabetes and preparation method thereof

The technology of metformin and composition is applied in the field of pharmaceutical composition for treating diabetes and its preparation field, which can solve problems such as restricting the use of metformin, and achieve the effects of avoiding gastrointestinal adverse reactions, improving treatment effect and improving insulin resistance.

Active Publication Date: 2014-06-25
贵州天安药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of treating obese diabetes is very good, so it is widely used clinically. The common adverse reactions of metformin are gastrointestinal discomfort, such as nausea, vomiting, diarrhea, abdominal pain, constipation, abdominal distension, indigestion, and heartburn. Up to 30%, this adverse effect limits the use of metformin

Method used

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  • Medicine composition containing melbine for treating diabetes and preparation method thereof
  • Medicine composition containing melbine for treating diabetes and preparation method thereof
  • Medicine composition containing melbine for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0035] Metformin 500g, Pinellia 2000g, Ginger 3000g, Citrus aurantium 3000g, Chenpi 2000g, Coptis 2000g.

[0036] The preparation method of the pharmaceutical composition for treating diabetes:

[0037] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add 5 times the amount of water for the second time, decoct for 1 hour, combine and decoct liquid, spare;

[0038] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;

[0039] c. Metformin is mixed with dry medicinal powder, and gran...

Embodiment 2

[0043] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0044] Metformin 400g, Pinellia 2200g, Ginger 2800g, Citrus aurantium 3200g, Chenpi 1800g, Coptis 1800g.

[0045] The preparation method of the pharmaceutical composition for treating diabetes:

[0046] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times. Add 8 times the amount of water for the first time and decoct for 2 hours. Add 6 times the amount of water for the second time and decoct for 1.5 hours. Combine and decoct liquid, spare;

[0047] b. Concentrate the decoction at 55°C and -0.08Mpa into a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;

[0048] c. Metformin is mixed with dry medicinal powder,...

Embodiment 3

[0052] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0053] Metformin 600g, Pinellia 1800g, Ginger 3200g, Citrus aurantium 2800g, Chenpi 2200g, Coptis 2200g.

[0054] The preparation method of the pharmaceutical composition for treating diabetes:

[0055] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the amount of water for the second time, decoct for 0.5 hours, and decoct together liquid, spare;

[0056] b. Concentrate the decoction liquid at 65°C and -0.04Mpa to a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;

[0057] c. Metformin is mixed with dry medicinal powder, and granu...

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Abstract

The invention belongs to the field of medical technology, and particularly relates to a medicine composition containing melbine for treating diabetes and a preparation method thereof. The medicine composition containing melbine comprises following raw materials in parts by weight: 250-750 parts of melbine, 1500-2500 parts of pinellia ternate, 2500-3500 parts of fresh ginger, 2500-3500 parts of fructus aurantii, 1500-2500 parts of pericarpium citri reticulatae, and 1500-2500 parts of coptis. The medicine combines traditional Chinese medicines with melbine, can avoid common untoward effect of gastrointestinal tract caused by melbine, and improves the curative effect on diabetes.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing metformin for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of insul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61P3/10A61K31/155
Inventor 孟小斐
Owner 贵州天安药业股份有限公司
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