Medicine composition containing melbine for treating diabetes and preparation method thereof
The technology of metformin and composition is applied in the field of pharmaceutical composition for treating diabetes and its preparation field, which can solve problems such as restricting the use of metformin, and achieve the effects of avoiding gastrointestinal adverse reactions, improving treatment effect and improving insulin resistance.
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Embodiment 1
[0034] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:
[0035] Metformin 500g, Pinellia 2000g, Ginger 3000g, Citrus aurantium 3000g, Chenpi 2000g, Coptis 2000g.
[0036] The preparation method of the pharmaceutical composition for treating diabetes:
[0037] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add 5 times the amount of water for the second time, decoct for 1 hour, combine and decoct liquid, spare;
[0038] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;
[0039] c. Metformin is mixed with dry medicinal powder, and gran...
Embodiment 2
[0043] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:
[0044] Metformin 400g, Pinellia 2200g, Ginger 2800g, Citrus aurantium 3200g, Chenpi 1800g, Coptis 1800g.
[0045] The preparation method of the pharmaceutical composition for treating diabetes:
[0046] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times. Add 8 times the amount of water for the first time and decoct for 2 hours. Add 6 times the amount of water for the second time and decoct for 1.5 hours. Combine and decoct liquid, spare;
[0047] b. Concentrate the decoction at 55°C and -0.08Mpa into a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;
[0048] c. Metformin is mixed with dry medicinal powder,...
Embodiment 3
[0052] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:
[0053] Metformin 600g, Pinellia 1800g, Ginger 3200g, Citrus aurantium 2800g, Chenpi 2200g, Coptis 2200g.
[0054] The preparation method of the pharmaceutical composition for treating diabetes:
[0055] a. Add water to decoct pinellia, ginger, citrus aurantium, tangerine peel, and coptis 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the amount of water for the second time, decoct for 0.5 hours, and decoct together liquid, spare;
[0056] b. Concentrate the decoction liquid at 65°C and -0.04Mpa to a clear paste with a relative density of 1.08 to 1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 clear ointment, spray-dried to obtain dry powder;
[0057] c. Metformin is mixed with dry medicinal powder, and granu...
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