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Glibenclamide containing pharmaceutical composition for treating diabetes and preparation method thereof

A composition and diabetes technology, applied in the field of medicine, can solve problems such as restricting the use of glibenclamide, achieve the effects of improving insulin resistance, improving therapeutic effect, and protecting islet cell function

Inactive Publication Date: 2016-06-22
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of treating obese diabetes is very good, so it is widely used clinically. The common adverse reactions of glibenclamide are gastrointestinal reactions, such as nausea, vomiting, diarrhea, abdominal pain, constipation, abdominal distension, indigestion, heartburn, etc. These adverse reactions are as high as 25%, and this adverse reaction limits the use of glibenclamide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0039] Glibenclamide 2.5g, Fujian Cypress 6000g, Hongguonan 6000g, Loquat Leaf 6000g, Shishi 6000g.

[0040] The preparation method of the pharmaceutical composition for treating diabetes:

[0041] a. Decoct Fujian Cypress, Hongguo Nan, Loquat Leaf, and Shishi with water twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water for 5 times the volume of the medicine for the second time, and decoct for 1 hour , combine the decoction, set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing glibenclamide and dry powder, and granulating to...

Embodiment 2

[0047] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0048] Glibenclamide 3g, Fujian cypress 7000g, Hongguonan 5000g, loquat leaves 7000g, Shishi 5000g.

[0049] The preparation method of the pharmaceutical composition for treating diabetes:

[0050] a. Decoct Fujian Cypress, Hongguo Nan, Loquat Leaf, and Shishi with water twice, add 8 volumes of water for the first time, decoct for 2 hours, add 6 times the volume of medicine for the second time, decoct for 1.5 hours , combine the decoction, set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing glibenclamide and dry powder, and granulating to obtain the acti...

Embodiment 3

[0056] A kind of pharmaceutical composition for treating diabetes, is made up of the crude drug of following proportioning by weight:

[0057] Glibenclamide 2g, Fujian cypress 5000g, Hongguonan 7000g, loquat leaves 5000g, Shishi 7000g.

[0058] The preparation method of the pharmaceutical composition for treating diabetes:

[0059] a. Boil Fujian Cypress, Hongguo Nan, Loquat Leaf, and Shishi with water for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the volume of medicine for the second time, and decoct for 0.5 hours , combine the decoction, set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing glibenclamide and dry powder, and granulating to obtain t...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a glibenclamide containing pharmaceutical composition for treating diabetes and a preparation method thereof. The glibenclamide containing pharmaceutical composition for treating the diabetes, provided by the invention, is prepared from the following raw pharmaceutical materials in parts by weight: 1-4 parts of glibenclamide, 4,000-8,000 parts of Fokienia hodginsii, 4,000-8,000 parts of Actinodaphne cupularis, 4,000-8,000 parts of Eriobotrya japonica and 4,000-8,000 parts of carex Kobomugi. According to the glibenclamide containing pharmaceutical composition for treating the diabetes and the preparation method thereof, the traditional Chinese medicines and the glibenclamide are combined, so that common gastrointestinal-tract adverse reactions of the glibenclamide can be avoided, and the treatment effect on the diabetes is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing glibenclamide for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is the second killer of modern diseases, and its harm to the human body is second only to cancer. In fact, diabetes itself is not terrible, what is terrible is the complications of diabetes, almost all the harm caused by diabetes comes from its complications. Among the diabetic patients in our country, there are as many as 12 million with high blood pressure, 5 million with stroke, 6 million with coronary heart disease, 450,000 with blindness, and 500,000 with uremia. [0003] Diabetes mellitus is a complex disease of multiple etiologies. It is a syndrome of glucose, protein and lipid metabolism disorders caused by the lack of insulin in the body or the increase of hormones that antagonize insulin, or the inability of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/16A61P3/10A61K31/64
CPCA61K31/64A61K9/1652A61K36/14A61K36/54A61K36/73A61K36/8905A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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