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Automatic in vitro transdermal vertical diffusion test device

A diffusion test and fully automatic technology, applied in measuring devices, diffusion analysis, instruments, etc., can solve problems such as difficult exhaust, uncontrollable human error, inconvenient liquid intake and rehydration, etc.

Inactive Publication Date: 2018-08-14
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, manual sampling has the disadvantages of high energy consumption and uncontrollable human error, especially the vertical diffusion cell has problems such as inconvenient liquid collection and rehydration and difficult exhaust due to the small diameter of the sampling tube

Method used

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  • Automatic in vitro transdermal vertical diffusion test device

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Embodiment Construction

[0012] As shown in Figure 1, the fully automatic in vitro transdermal vertical diffusion test device provided by the present invention includes a four-way rotary valve 11, a heating block 7 and a controller. The four-way rotary valve 11 is connected with a supplementary liquid bottle 10, a vertical diffusion Pool group, multi-channel injection pump group and sample collector, a replenishment liquid connection hose 23 is provided between the four-way rotary valve 11 and the replenishment liquid bottle 10; a sampling chamber is provided between the four-way rotary valve 11 and the vertical diffusion cell group A connecting hose 24; a syringe pump connecting hose 25 is provided between the four-way rotary valve 11 and the multi-channel injection pump group; a collector connecting hose 17 is provided between the four-way rotary valve 11 and the sample collector, and the A thermostat 9 is provided under the replenishing liquid bottle 10, and the vertical diffusion cell group is comp...

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Abstract

The invention discloses a full-automatic in-vitro transdermal vertical dispersion testing device. The device comprises a four-way rotary valve, a heating block and a controller, wherein the four-way rotary valve is connected with a supplementing liquid bottle, a vertical dispersion tank group, a multi-channel injection pump group and a sample collector and is provided with a connection hose respectively; a constant-temperature device is arranged under the supplementing liquid bottle; vertical dispersion tanks in the vertical dispersion tank group are arranged in a heating groove in the heating block; the heating block is provided with a stepping motor, a temperature sensor, a heating sheet and an electromagnetic stirrer; and the constant-temperature device, the four-way rotary valve, the stepping motor, the temperature sensor, the heating sheet, the electromagnetic stirrer, the multi-channel injection pump group, the sample collector and the controller are connected through electric wires respectively. The full-automatic in-vitro transdermal vertical dispersion testing device has the advantages of automatically sampling at fixed time, supplementing media, exhausting, collecting samples and washing pipelines, and completing a full-automatic in-vitro transdermal vertical dispersion test.

Description

technical field [0001] The invention belongs to the technical field of in vitro transdermal diffusion test equipment for transdermal drug preparations, and in particular relates to a fully automatic in vitro transdermal vertical diffusion test device. Background technique [0002] The main method used in the in vitro transdermal diffusion test of transdermal preparations is the diffusion cell method. This method can reflect the speed and degree of drug penetration through the skin of living animals, and can screen the prescription of transdermal drug preparations. It is currently an internationally recognized standard detection method for drug transdermal absorption tests. There are two main types of diffusion cells used in in vitro transdermal diffusion tests, single-chamber diffusion cell and double-chamber diffusion cell. Single-chamber diffusion cells are mainly Franz diffusion cells and improved Franz diffusion cells. The Franz diffusion cell is a vertical diffusion c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N13/04
CPCG01N13/04G01N2013/003
Inventor 朴相范方亮李东浩
Owner YANBIAN UNIV
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